Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018
BackgroundMuscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle mass index (ASMI) and phenotypic age(PhenoAge), while examining the mediating role of systemic...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2024.1503702/full |
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| author | Shifu Bao Shifu Bao Weibu Jimu Weibu Jimu Nai Mu Fang Yan Shuxing Xing Tao Li Zheng Zhou |
| author_facet | Shifu Bao Shifu Bao Weibu Jimu Weibu Jimu Nai Mu Fang Yan Shuxing Xing Tao Li Zheng Zhou |
| author_sort | Shifu Bao |
| collection | DOAJ |
| description | BackgroundMuscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle mass index (ASMI) and phenotypic age(PhenoAge), while examining the mediating role of systemic inflammation.MethodsThe analysis included 7,440 participants from the NHANES 2011–2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as the residuals from regressing PhenoAge on chronological age. Multivariable linear regression analyses were performed to assess the association between ASMI and PhenoAgeAccel. Mediation analysis was conducted to quantify the extent to which systemic inflammation contributes to this association.ResultsOur analysis revealed that higher ASMI is linked to slower biological aging, as evidenced by lower PhenoAgeAccel (β = −0.48, 95% CI: −0.66 to −0.29, p = 0.0001). Systemic inflammation partially mediated this effect, with a mediation proportion of 35.1%. The association varied notably across demographic and health-related subgroups, being particularly significant in females, individuals with obesity, and those with lower physical activity.ConclusionThese findings highlight the critical importance of muscle mass in slowing biological aging, with systemic inflammation emerging as a key biological mediator. The public health implications are substantial, suggesting that targeted interventions—such as resistance training, anti-inflammatory diets, and personalized medical approaches—could play a pivotal role in decelerating biological aging and improving long-term health outcomes. |
| format | Article |
| id | doaj-art-644bed83d20d45eeb940e3fc9f74bea8 |
| institution | Kabale University |
| issn | 2296-861X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Nutrition |
| spelling | doaj-art-644bed83d20d45eeb940e3fc9f74bea82025-01-06T05:13:15ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2025-01-011110.3389/fnut.2024.15037021503702Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018Shifu Bao0Shifu Bao1Weibu Jimu2Weibu Jimu3Nai Mu4Fang Yan5Shuxing Xing6Tao Li7Zheng Zhou8Department of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Orthopedics, Chengdu Fifth People's Hospital, Chengdu, ChinaDepartment of Medicine and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, ChinaDepartment of Orthopedics, Chengdu Fifth People's Hospital, Chengdu, ChinaDepartment of Orthopedics, Chengdu Fifth People's Hospital, Chengdu, ChinaDepartment of Geriatrics, Chengdu Fifth People's Hospital, Chengdu, ChinaDepartment of Orthopedics, Chengdu Fifth People's Hospital, Chengdu, ChinaDepartment of Orthopedic Surgery and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Orthopedics, Chengdu Fifth People's Hospital, Chengdu, ChinaBackgroundMuscle mass plays a pivotal role in health maintenance, yet its connection to biological aging remains underexplored. This study investigates the association between appendicular skeletal muscle mass index (ASMI) and phenotypic age(PhenoAge), while examining the mediating role of systemic inflammation.MethodsThe analysis included 7,440 participants from the NHANES 2011–2018. Phenotypic Age Acceleration (PhenoAgeAccel) was calculated as the residuals from regressing PhenoAge on chronological age. Multivariable linear regression analyses were performed to assess the association between ASMI and PhenoAgeAccel. Mediation analysis was conducted to quantify the extent to which systemic inflammation contributes to this association.ResultsOur analysis revealed that higher ASMI is linked to slower biological aging, as evidenced by lower PhenoAgeAccel (β = −0.48, 95% CI: −0.66 to −0.29, p = 0.0001). Systemic inflammation partially mediated this effect, with a mediation proportion of 35.1%. The association varied notably across demographic and health-related subgroups, being particularly significant in females, individuals with obesity, and those with lower physical activity.ConclusionThese findings highlight the critical importance of muscle mass in slowing biological aging, with systemic inflammation emerging as a key biological mediator. The public health implications are substantial, suggesting that targeted interventions—such as resistance training, anti-inflammatory diets, and personalized medical approaches—could play a pivotal role in decelerating biological aging and improving long-term health outcomes.https://www.frontiersin.org/articles/10.3389/fnut.2024.1503702/fullPhenoAgeskeletal muscleagingSIINHANEScross-sectional study |
| spellingShingle | Shifu Bao Shifu Bao Weibu Jimu Weibu Jimu Nai Mu Fang Yan Shuxing Xing Tao Li Zheng Zhou Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018 Frontiers in Nutrition PhenoAge skeletal muscle aging SII NHANES cross-sectional study |
| title | Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018 |
| title_full | Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018 |
| title_fullStr | Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018 |
| title_full_unstemmed | Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018 |
| title_short | Inflammation mediates the association between muscle mass and accelerated phenotypic aging: results from the NHANES 2011–2018 |
| title_sort | inflammation mediates the association between muscle mass and accelerated phenotypic aging results from the nhanes 2011 2018 |
| topic | PhenoAge skeletal muscle aging SII NHANES cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2024.1503702/full |
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