Risk assessment of complex organoarsenic species in food
Abstract The European Commission asked EFSA for a risk assessment on complex organoarsenic species in food. They are typically found in marine foods and comprise mainly arsenobetaine (AsB), arsenosugars and arsenolipids. For AsB, no reference point (RP) could be derived because of insufficient toxic...
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Wiley
2024-12-01
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| Series: | EFSA Journal |
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| Online Access: | https://doi.org/10.2903/j.efsa.2024.9112 |
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| author | EFSA Panel on Contaminants in the Food Chain (CONTAM) Helle Katrine Knutsen Agneta Åkesson Vasileios Bampidis Margherita Bignami Laurent Bodin James Kevin Chipman Gisela Degen Antonio Hernández‐Jerez Tim Hofer Christer Hogstrand Stefano Landi Jean‐Charles Leblanc Kyriaki Machera Evangelia Ntzani Guido Rychen Salomon Sand Katharina Vejdovszky Barbara Viviani Lars Barregård Diane Benford Eugenia Dogliotti Kevin Francesconi Jose Ángel Gómez Ruiz Hans Steinkellner Tanja Schwerdtle |
| author_facet | EFSA Panel on Contaminants in the Food Chain (CONTAM) Helle Katrine Knutsen Agneta Åkesson Vasileios Bampidis Margherita Bignami Laurent Bodin James Kevin Chipman Gisela Degen Antonio Hernández‐Jerez Tim Hofer Christer Hogstrand Stefano Landi Jean‐Charles Leblanc Kyriaki Machera Evangelia Ntzani Guido Rychen Salomon Sand Katharina Vejdovszky Barbara Viviani Lars Barregård Diane Benford Eugenia Dogliotti Kevin Francesconi Jose Ángel Gómez Ruiz Hans Steinkellner Tanja Schwerdtle |
| author_sort | EFSA Panel on Contaminants in the Food Chain (CONTAM) |
| collection | DOAJ |
| description | Abstract The European Commission asked EFSA for a risk assessment on complex organoarsenic species in food. They are typically found in marine foods and comprise mainly arsenobetaine (AsB), arsenosugars and arsenolipids. For AsB, no reference point (RP) could be derived because of insufficient toxicity data. AsB did not show adverse effects in the two available repeat dose toxicity tests in rodents. It has not shown genotoxicity in in vitro assays. There is no indication of an association with adverse outcomes in human studies. The highest 95th percentile exposure for AsB was observed in ‘Toddlers’ with an estimate of 12.5 μg As/kg bw per day (AsB expressed as elemental arsenic). There is sufficient evidence to conclude that AsB at current dietary exposure levels does not raise a health concern. For glycerol arsenosugar (AsSugOH) a RP of 0.85 mg As/kg bw per day was derived based on the BMDL10 values for cognitive and motor function in mice. A margin of exposure (MOE) of ≥ 1000 would not raise a health concern. The highest 95th percentile estimate of exposure for AsSugOH (for adult consumers of red seaweed Nori/Laver) was 0.71 μg As/kg bw per day (AsSugOH expressed as elemental arsenic), which results in an MOE > 1000, not raising a health concern. Based on qualitative consideration of all identified uncertainties, it is regarded likely that the dietary exposures to AsB and AsSugOH do not raise a health concern. No conclusions could be drawn regarding other arsenosugars. No risk characterisation could be conducted for arsenolipids, due to the lack of data. |
| format | Article |
| id | doaj-art-64371965116d4bf086e8b38eee66d08f |
| institution | Kabale University |
| issn | 1831-4732 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | EFSA Journal |
| spelling | doaj-art-64371965116d4bf086e8b38eee66d08f2025-01-17T06:31:16ZengWileyEFSA Journal1831-47322024-12-012212n/an/a10.2903/j.efsa.2024.9112Risk assessment of complex organoarsenic species in foodEFSA Panel on Contaminants in the Food Chain (CONTAM)Helle Katrine KnutsenAgneta ÅkessonVasileios BampidisMargherita BignamiLaurent BodinJames Kevin ChipmanGisela DegenAntonio Hernández‐JerezTim HoferChrister HogstrandStefano LandiJean‐Charles LeblancKyriaki MacheraEvangelia NtzaniGuido RychenSalomon SandKatharina VejdovszkyBarbara VivianiLars BarregårdDiane BenfordEugenia DogliottiKevin FrancesconiJose Ángel Gómez RuizHans SteinkellnerTanja SchwerdtleAbstract The European Commission asked EFSA for a risk assessment on complex organoarsenic species in food. They are typically found in marine foods and comprise mainly arsenobetaine (AsB), arsenosugars and arsenolipids. For AsB, no reference point (RP) could be derived because of insufficient toxicity data. AsB did not show adverse effects in the two available repeat dose toxicity tests in rodents. It has not shown genotoxicity in in vitro assays. There is no indication of an association with adverse outcomes in human studies. The highest 95th percentile exposure for AsB was observed in ‘Toddlers’ with an estimate of 12.5 μg As/kg bw per day (AsB expressed as elemental arsenic). There is sufficient evidence to conclude that AsB at current dietary exposure levels does not raise a health concern. For glycerol arsenosugar (AsSugOH) a RP of 0.85 mg As/kg bw per day was derived based on the BMDL10 values for cognitive and motor function in mice. A margin of exposure (MOE) of ≥ 1000 would not raise a health concern. The highest 95th percentile estimate of exposure for AsSugOH (for adult consumers of red seaweed Nori/Laver) was 0.71 μg As/kg bw per day (AsSugOH expressed as elemental arsenic), which results in an MOE > 1000, not raising a health concern. Based on qualitative consideration of all identified uncertainties, it is regarded likely that the dietary exposures to AsB and AsSugOH do not raise a health concern. No conclusions could be drawn regarding other arsenosugars. No risk characterisation could be conducted for arsenolipids, due to the lack of data.https://doi.org/10.2903/j.efsa.2024.9112Arsenobetainearsenolipidsarsenosugarscomplex organoarsenic speciesmargin of exposure (MOE)risk assessment |
| spellingShingle | EFSA Panel on Contaminants in the Food Chain (CONTAM) Helle Katrine Knutsen Agneta Åkesson Vasileios Bampidis Margherita Bignami Laurent Bodin James Kevin Chipman Gisela Degen Antonio Hernández‐Jerez Tim Hofer Christer Hogstrand Stefano Landi Jean‐Charles Leblanc Kyriaki Machera Evangelia Ntzani Guido Rychen Salomon Sand Katharina Vejdovszky Barbara Viviani Lars Barregård Diane Benford Eugenia Dogliotti Kevin Francesconi Jose Ángel Gómez Ruiz Hans Steinkellner Tanja Schwerdtle Risk assessment of complex organoarsenic species in food EFSA Journal Arsenobetaine arsenolipids arsenosugars complex organoarsenic species margin of exposure (MOE) risk assessment |
| title | Risk assessment of complex organoarsenic species in food |
| title_full | Risk assessment of complex organoarsenic species in food |
| title_fullStr | Risk assessment of complex organoarsenic species in food |
| title_full_unstemmed | Risk assessment of complex organoarsenic species in food |
| title_short | Risk assessment of complex organoarsenic species in food |
| title_sort | risk assessment of complex organoarsenic species in food |
| topic | Arsenobetaine arsenolipids arsenosugars complex organoarsenic species margin of exposure (MOE) risk assessment |
| url | https://doi.org/10.2903/j.efsa.2024.9112 |
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