Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish
Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2012/462161 |
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| _version_ | 1841524728489050112 |
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| author | Mirjam Keßler Steffen Just Wolfgang Rottbauer |
| author_facet | Mirjam Keßler Steffen Just Wolfgang Rottbauer |
| author_sort | Mirjam Keßler |
| collection | DOAJ |
| description | Ion channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels also feature ion flux independent functions during heart development and morphogenesis. The zebrafish is a well-established animal model to decipher the genetics of cardiovascular development and disease of vertebrates. In large scale forward genetics screens, hundreds of mutant lines have been isolated with defects in cardiovascular structure and function. Detailed phenotyping of these lines and identification of the causative genetic defects revealed new insights into ion flux dependent and independent functions of various cardiac ion channels. |
| format | Article |
| id | doaj-art-63fc38a301a6484eb40ffec2064c3269 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-63fc38a301a6484eb40ffec2064c32692025-02-03T05:47:31ZengWileyStem Cells International1687-966X1687-96782012-01-01201210.1155/2012/462161462161Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from ZebrafishMirjam Keßler0Steffen Just1Wolfgang Rottbauer2Department of Internal Medicine II, University of Ulm, 89081 Ulm, GermanyDepartment of Internal Medicine II, University of Ulm, 89081 Ulm, GermanyDepartment of Internal Medicine II, University of Ulm, 89081 Ulm, GermanyIon channels orchestrate directed flux of ions through membranes and are essential for a wide range of physiological processes including depolarization and repolarization of biomechanical activity of cells. Besides their electrophysiological functions in the heart, recent findings have demonstrated that ion channels also feature ion flux independent functions during heart development and morphogenesis. The zebrafish is a well-established animal model to decipher the genetics of cardiovascular development and disease of vertebrates. In large scale forward genetics screens, hundreds of mutant lines have been isolated with defects in cardiovascular structure and function. Detailed phenotyping of these lines and identification of the causative genetic defects revealed new insights into ion flux dependent and independent functions of various cardiac ion channels.http://dx.doi.org/10.1155/2012/462161 |
| spellingShingle | Mirjam Keßler Steffen Just Wolfgang Rottbauer Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish Stem Cells International |
| title | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
| title_full | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
| title_fullStr | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
| title_full_unstemmed | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
| title_short | Ion Flux Dependent and Independent Functions of Ion Channels in the Vertebrate Heart: Lessons Learned from Zebrafish |
| title_sort | ion flux dependent and independent functions of ion channels in the vertebrate heart lessons learned from zebrafish |
| url | http://dx.doi.org/10.1155/2012/462161 |
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