Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantoms
Introduction Several positive clinical trials have demonstrated that capacitive hyperthermia (CHT) improves the effectiveness of radiation therapy for the treatment of various cancer entities. However, the ability of CHT to induce significant heating throughout the body is under debate.Objectives To...
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Taylor & Francis Group
2024-12-01
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| Series: | International Journal of Hyperthermia |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2024.2416999 |
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| author | Rami Muratoglu Dominik Gerster Jacek Nadobny Alexander Hansch Paul Krahl Paraskevi Danai Veltsista Marcus Beck Daniel Zips Pirus Ghadjar |
| author_facet | Rami Muratoglu Dominik Gerster Jacek Nadobny Alexander Hansch Paul Krahl Paraskevi Danai Veltsista Marcus Beck Daniel Zips Pirus Ghadjar |
| author_sort | Rami Muratoglu |
| collection | DOAJ |
| description | Introduction Several positive clinical trials have demonstrated that capacitive hyperthermia (CHT) improves the effectiveness of radiation therapy for the treatment of various cancer entities. However, the ability of CHT to induce significant heating throughout the body is under debate.Objectives To perform a pilot study involving comparisons of computer simulations and experimental data using different split-phantoms to validate hyperthermia treatment modeling for pre-planning for a clinical CHT system and to investigate the feasibility of split-phantom measurements in capacitive hyperthermia.Materials and methods The CHT system EHY-2030 (Oncotherm, Budapest, Hungary) was used. The system provides two electrode sizes, but only the smaller electrode, indicated as D200 electrode, was investigated in this pilot study. Horizontally and vertically splittable, different multi-slice phantoms with dielectric material properties simulating muscle and electrically low conductive fat were produced and heated. During the heating procedure, temperature-time curves were measured, and thermal images were captured. Specific absorption rate values were derived from the temperature rise (TR) values. Concomitantly, computer field simulations utilizing a detailed CAD-based model of the CHT system were performed using the simulation platform Sim4Life and compared with measurements.Results For the investigated electrode D200 the system power of 75 W was applied, which is half of the maximum power of 150 W and lies in the range of usual values for this electrode applied in patient treatments in our clinic. For 75 W, a heating of 3.6 °C in 6 min in a depth of 1 cm in an agar-based, muscle tissue-equivalent phantom was achieved. The addition of a 1 cm thick, synthetic, low dielectric fat layer reduced the TR up until a depth of 8.5 cm by on average around 38% (from 8.5 cm onwards the absolute local TR is similar, deviations are ≤0.1 °C). In terms of point-to-point absolute SAR comparison (without any normalization), up to a depth of 11 cm in the phantoms central vertical plot, the simulation differs from the measured TR points by on average 25% (ranging from 7% to 36%) for the homogeneous phantom and by on average 43% (ranging from 26% to 60%) for the inhomogeneous phantom.Conclusion Computer simulations and experimental data were compared for the CHT system EHY-2030 using the D200 electrode, applying a thermal imaging technique for different vertically splittable phantoms. This pilot study data can be used as a guidance regarding the expected heating for this commonly used electrode size but also to further elucidate the significance of non-thermal anticancer effects. Further studies are needed for different sizes and geometries of electrodes and phantoms. |
| format | Article |
| id | doaj-art-63bee77b1edd4a238d118c7ba22730f9 |
| institution | Kabale University |
| issn | 0265-6736 1464-5157 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
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| series | International Journal of Hyperthermia |
| spelling | doaj-art-63bee77b1edd4a238d118c7ba22730f92025-01-03T09:30:27ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572024-12-0141110.1080/02656736.2024.2416999Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantomsRami Muratoglu0Dominik Gerster1Jacek Nadobny2Alexander Hansch3Paul Krahl4Paraskevi Danai Veltsista5Marcus Beck6Daniel Zips7Pirus Ghadjar8Department of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyDepartment of Radiation Oncology, Charité – Universitätsmedizin Berlin, Berlin, GermanyIntroduction Several positive clinical trials have demonstrated that capacitive hyperthermia (CHT) improves the effectiveness of radiation therapy for the treatment of various cancer entities. However, the ability of CHT to induce significant heating throughout the body is under debate.Objectives To perform a pilot study involving comparisons of computer simulations and experimental data using different split-phantoms to validate hyperthermia treatment modeling for pre-planning for a clinical CHT system and to investigate the feasibility of split-phantom measurements in capacitive hyperthermia.Materials and methods The CHT system EHY-2030 (Oncotherm, Budapest, Hungary) was used. The system provides two electrode sizes, but only the smaller electrode, indicated as D200 electrode, was investigated in this pilot study. Horizontally and vertically splittable, different multi-slice phantoms with dielectric material properties simulating muscle and electrically low conductive fat were produced and heated. During the heating procedure, temperature-time curves were measured, and thermal images were captured. Specific absorption rate values were derived from the temperature rise (TR) values. Concomitantly, computer field simulations utilizing a detailed CAD-based model of the CHT system were performed using the simulation platform Sim4Life and compared with measurements.Results For the investigated electrode D200 the system power of 75 W was applied, which is half of the maximum power of 150 W and lies in the range of usual values for this electrode applied in patient treatments in our clinic. For 75 W, a heating of 3.6 °C in 6 min in a depth of 1 cm in an agar-based, muscle tissue-equivalent phantom was achieved. The addition of a 1 cm thick, synthetic, low dielectric fat layer reduced the TR up until a depth of 8.5 cm by on average around 38% (from 8.5 cm onwards the absolute local TR is similar, deviations are ≤0.1 °C). In terms of point-to-point absolute SAR comparison (without any normalization), up to a depth of 11 cm in the phantoms central vertical plot, the simulation differs from the measured TR points by on average 25% (ranging from 7% to 36%) for the homogeneous phantom and by on average 43% (ranging from 26% to 60%) for the inhomogeneous phantom.Conclusion Computer simulations and experimental data were compared for the CHT system EHY-2030 using the D200 electrode, applying a thermal imaging technique for different vertically splittable phantoms. This pilot study data can be used as a guidance regarding the expected heating for this commonly used electrode size but also to further elucidate the significance of non-thermal anticancer effects. Further studies are needed for different sizes and geometries of electrodes and phantoms.https://www.tandfonline.com/doi/10.1080/02656736.2024.2416999Capacitive hyperthermiaphantom measurementssimulationtreatment planningnon-thermal effectsSim4Life |
| spellingShingle | Rami Muratoglu Dominik Gerster Jacek Nadobny Alexander Hansch Paul Krahl Paraskevi Danai Veltsista Marcus Beck Daniel Zips Pirus Ghadjar Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantoms International Journal of Hyperthermia Capacitive hyperthermia phantom measurements simulation treatment planning non-thermal effects Sim4Life |
| title | Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantoms |
| title_full | Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantoms |
| title_fullStr | Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantoms |
| title_full_unstemmed | Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantoms |
| title_short | Comparisons of computer simulations and experimental data for capacitive hyperthermia using different split-phantoms |
| title_sort | comparisons of computer simulations and experimental data for capacitive hyperthermia using different split phantoms |
| topic | Capacitive hyperthermia phantom measurements simulation treatment planning non-thermal effects Sim4Life |
| url | https://www.tandfonline.com/doi/10.1080/02656736.2024.2416999 |
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