A Simulation Study on Adaptive Assignment Versus Randomizations in Clinical Trials
This study investigates a sequential clinical trial comparing two treatments with dichotomous outcomes. We evaluate the effectiveness of five adaptive procedures and three randomization methods for assigning patients to different therapies. The primary objective is to identify an optimal treatment a...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-12-01
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| Series: | Mathematics |
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| Online Access: | https://www.mdpi.com/2227-7390/13/1/44 |
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| _version_ | 1841549143035609088 |
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| author | Chien-Tai Lin Yun-Wei Li Yi-Jun Hong |
| author_facet | Chien-Tai Lin Yun-Wei Li Yi-Jun Hong |
| author_sort | Chien-Tai Lin |
| collection | DOAJ |
| description | This study investigates a sequential clinical trial comparing two treatments with dichotomous outcomes. We evaluate the effectiveness of five adaptive procedures and three randomization methods for assigning patients to different therapies. The primary objective is to identify an optimal treatment allocation policy that maximizes the proportion of successful outcomes in a trial. By comparing the performance of adaptive and randomized procedures, this research provides valuable insights for enhancing treatment allocation strategies in clinical trials, ultimately aiming to improve the overall success rates of therapeutic interventions. |
| format | Article |
| id | doaj-art-639a3587eb514fc9a7c26944e92df6a4 |
| institution | Kabale University |
| issn | 2227-7390 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Mathematics |
| spelling | doaj-art-639a3587eb514fc9a7c26944e92df6a42025-01-10T13:18:04ZengMDPI AGMathematics2227-73902024-12-011314410.3390/math13010044A Simulation Study on Adaptive Assignment Versus Randomizations in Clinical TrialsChien-Tai Lin0Yun-Wei Li1Yi-Jun Hong2Department of Mathematics, Tamkang University, New Taipei City 251301, TaiwanInstitute of Hospital and Health Care Administration, National Yang Ming Chiao Tung University, Taipei 112304, TaiwanDepartment of Mathematics, Tamkang University, New Taipei City 251301, TaiwanThis study investigates a sequential clinical trial comparing two treatments with dichotomous outcomes. We evaluate the effectiveness of five adaptive procedures and three randomization methods for assigning patients to different therapies. The primary objective is to identify an optimal treatment allocation policy that maximizes the proportion of successful outcomes in a trial. By comparing the performance of adaptive and randomized procedures, this research provides valuable insights for enhancing treatment allocation strategies in clinical trials, ultimately aiming to improve the overall success rates of therapeutic interventions.https://www.mdpi.com/2227-7390/13/1/44adaptive proceduresconditional probability lostplay-the-winner/switch-from-a-loserrandomization methodsrobust Bayes |
| spellingShingle | Chien-Tai Lin Yun-Wei Li Yi-Jun Hong A Simulation Study on Adaptive Assignment Versus Randomizations in Clinical Trials Mathematics adaptive procedures conditional probability lost play-the-winner/switch-from-a-loser randomization methods robust Bayes |
| title | A Simulation Study on Adaptive Assignment Versus Randomizations in Clinical Trials |
| title_full | A Simulation Study on Adaptive Assignment Versus Randomizations in Clinical Trials |
| title_fullStr | A Simulation Study on Adaptive Assignment Versus Randomizations in Clinical Trials |
| title_full_unstemmed | A Simulation Study on Adaptive Assignment Versus Randomizations in Clinical Trials |
| title_short | A Simulation Study on Adaptive Assignment Versus Randomizations in Clinical Trials |
| title_sort | simulation study on adaptive assignment versus randomizations in clinical trials |
| topic | adaptive procedures conditional probability lost play-the-winner/switch-from-a-loser randomization methods robust Bayes |
| url | https://www.mdpi.com/2227-7390/13/1/44 |
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