Ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer
Abstract This study aimed to evaluate the diagnostic accuracy of ultrasonography in assessing the response of clipped axillary lymph nodes to neoadjuvant chemotherapy. Between February 2022 and September 2023, 43 patients who underwent axillary lymph node marking for targeted axillary dissection wer...
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Nature Portfolio
2025-01-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-84827-w |
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| author | Ozge Aslan Aysenur Oktay Berk Goktepe Gurdeniz Serin |
| author_facet | Ozge Aslan Aysenur Oktay Berk Goktepe Gurdeniz Serin |
| author_sort | Ozge Aslan |
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| description | Abstract This study aimed to evaluate the diagnostic accuracy of ultrasonography in assessing the response of clipped axillary lymph nodes to neoadjuvant chemotherapy. Between February 2022 and September 2023, 43 patients who underwent axillary lymph node marking for targeted axillary dissection were retrospectively analyzed. Ultrasonography parameters such as the number, size, shape, cortical thickness, hilum status, and treatment response of the clipped lymph node were assessed. Post-surgery pathology results served as the gold standard. Ultrasonography revealed 70% complete and 30% partial response, while pathology results showed 51% complete response, 9% micro-metastases, and 40% macro-metastases. The diagnostic accuracy of ultrasonography was 81.4%, with 61.9% sensitivity and 100% specificity. A significant correlation was found between clipped node response in ultrasound and pathology. Additionally, a notable association was observed between clipped node response on ultrasonography, molecular subtype of the breast mass, and the mass’s response to NAC. Assessing the treatment response of clipped lymph nodes with preoperative ultrasound, followed by surgical excision using needle wire localization, can be a viable alternative to axillary dissection, offering low false-negative rates. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-63896db8b75e47f6bd96e848098d170c2025-01-05T12:21:26ZengNature PortfolioScientific Reports2045-23222025-01-011511810.1038/s41598-024-84827-wUltrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancerOzge Aslan0Aysenur Oktay1Berk Goktepe2Gurdeniz Serin3Department of Radiology, Ege University Faculty of Medicine, Ege University HospitalDepartment of Radiology, Ege University Faculty of Medicine, Ege University HospitalDepartment of General Surgery, Ege University Faculty of Medicine, Ege University HospitalDepartment of Medical Pathology, Ege University Faculty of Medicine, Ege University HospitalAbstract This study aimed to evaluate the diagnostic accuracy of ultrasonography in assessing the response of clipped axillary lymph nodes to neoadjuvant chemotherapy. Between February 2022 and September 2023, 43 patients who underwent axillary lymph node marking for targeted axillary dissection were retrospectively analyzed. Ultrasonography parameters such as the number, size, shape, cortical thickness, hilum status, and treatment response of the clipped lymph node were assessed. Post-surgery pathology results served as the gold standard. Ultrasonography revealed 70% complete and 30% partial response, while pathology results showed 51% complete response, 9% micro-metastases, and 40% macro-metastases. The diagnostic accuracy of ultrasonography was 81.4%, with 61.9% sensitivity and 100% specificity. A significant correlation was found between clipped node response in ultrasound and pathology. Additionally, a notable association was observed between clipped node response on ultrasonography, molecular subtype of the breast mass, and the mass’s response to NAC. Assessing the treatment response of clipped lymph nodes with preoperative ultrasound, followed by surgical excision using needle wire localization, can be a viable alternative to axillary dissection, offering low false-negative rates.https://doi.org/10.1038/s41598-024-84827-wBreast cancerTargeted axillary dissectionNode positiveMarkerClipNeedle wire localization |
| spellingShingle | Ozge Aslan Aysenur Oktay Berk Goktepe Gurdeniz Serin Ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer Scientific Reports Breast cancer Targeted axillary dissection Node positive Marker Clip Needle wire localization |
| title | Ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer |
| title_full | Ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer |
| title_fullStr | Ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer |
| title_full_unstemmed | Ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer |
| title_short | Ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer |
| title_sort | ultrasonographic accuracy in evaluating response of clipped lymph nodes in targeted axillary dissection in breast cancer |
| topic | Breast cancer Targeted axillary dissection Node positive Marker Clip Needle wire localization |
| url | https://doi.org/10.1038/s41598-024-84827-w |
| work_keys_str_mv | AT ozgeaslan ultrasonographicaccuracyinevaluatingresponseofclippedlymphnodesintargetedaxillarydissectioninbreastcancer AT aysenuroktay ultrasonographicaccuracyinevaluatingresponseofclippedlymphnodesintargetedaxillarydissectioninbreastcancer AT berkgoktepe ultrasonographicaccuracyinevaluatingresponseofclippedlymphnodesintargetedaxillarydissectioninbreastcancer AT gurdenizserin ultrasonographicaccuracyinevaluatingresponseofclippedlymphnodesintargetedaxillarydissectioninbreastcancer |