Repurposing FDA-approved drugs targeting FZD10 in nasopharyngeal carcinoma: insights from molecular dynamics simulations and experimental validation

Repurposing FDA-approved drugs targeting FZD10 in nasopharyngeal carcinoma: insights from molecular dynamics simulations and experimental validation

Abstract Wnt signaling is a critical pathway implicated in cancer development, with Frizzled proteins, particularly FZD10, playing key roles in tumorigenesis and recurrence. This study focuses on the potential of repurposed FDA-approved drugs targeting FZD10 as a therapeutic strategy for nasopharyng...

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Bibliographic Details
Main Authors: Chawalit Ngernsombat, Utid Suriya, Pongphol Prattapong, Kanika Verma, Thanyada Rungrotmongkol, Thananya Soonkum, Sakonwan Kuhaudomlarp, Tavan Janvilisri
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Scientific Reports
Subjects:
Drug repurposing
Wnt signaling
Nasopharyngeal carcinoma
Online Access:https://doi.org/10.1038/s41598-024-82967-7
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