Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling

Fbxo42 promotes the degradation of Ataxin-2 granules to trigger terminal Xbp1 signaling

Abstract The Unfolded Protein Response (UPR) is activated by the accumulation of misfolded proteins in the Endoplasmic Reticulum (ER), a condition known as ER stress. Prolonged ER stress and UPR activation cause cell death, by mechanisms that remain poorly understood. Here, we report that regulation...

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Main Authors: Cristiana C. Santos, Nadine Schweizer, Fátima Cairrão, Juanma Ramirez, Nerea Osinalde, Ming Yang, Catarina J. Gaspar, Vanya I. Rasheva, Miguel L. Trigo, Zach Hensel, Colin Adrain, Tiago N. Cordeiro, Franka Voigt, Paulo A. Gameiro, Ugo Mayor, Pedro M. Domingos
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62417-2
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