Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia

Mitochondrial abnormalities as a target of intervention in acute myeloid leukemia

Acute myeloid leukemia (AML) is an aggressive hematological malignancy; it is the most common acute leukemia in adults. AML prognosis is often poor, and relapse often occurs after initial remission. Recurrent genetic abnormalities underlying this disease and the presence of leukemic stem cells compl...

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Bibliographic Details
Main Authors: Elissa Tjahjono, Megan R. Daneman, Bernadetta Meika, Alexey V. Revtovich, Natalia V. Kirienko
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Oncology
Subjects:
acute myeloid leukemia
leukemic stem cells
mitochondria
oxidative phosphorylation
mitophagy
glutaminolysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1532857/full
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