Biocompatibility in hemodialysis: artificial membrane and human blood interactions
Abstract Hemodialysis, a cornerstone therapy for chronic kidney disease, represented a crucial advance in the evolution of artificial organs. While its success is largely due to its efficiency in removing uremic toxins, an equally important challenge is to uphold the primum non nocere principle by m...
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| Format: | Article |
| Language: | English |
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BMC
2025-08-01
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| Series: | BMC Nephrology |
| Online Access: | https://doi.org/10.1186/s12882-025-04401-y |
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| author | Eduardo Ávila Rodrigo A. Sepúlveda Jaime Retamal Daniel Hachim |
| author_facet | Eduardo Ávila Rodrigo A. Sepúlveda Jaime Retamal Daniel Hachim |
| author_sort | Eduardo Ávila |
| collection | DOAJ |
| description | Abstract Hemodialysis, a cornerstone therapy for chronic kidney disease, represented a crucial advance in the evolution of artificial organs. While its success is largely due to its efficiency in removing uremic toxins, an equally important challenge is to uphold the primum non nocere principle by minimizing the harmful effects of membrane–blood interactions. This review examines the complex mechanisms and key interactions underlying membrane biocompatibility, including complement activation, inflammation, and coagulation disturbances, paving the way for their clinical implications. We also summarize recent innovations in membrane materials and surface engineering aimed at improving hemocompatibility and promoting safer hemodialysis treatments for improved clinical outcomes. |
| format | Article |
| id | doaj-art-63534b7cb5eb4ccd92f94eef7805c8fe |
| institution | Kabale University |
| issn | 1471-2369 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj-art-63534b7cb5eb4ccd92f94eef7805c8fe2025-08-24T11:12:52ZengBMCBMC Nephrology1471-23692025-08-0126113210.1186/s12882-025-04401-yBiocompatibility in hemodialysis: artificial membrane and human blood interactionsEduardo Ávila0Rodrigo A. Sepúlveda1Jaime Retamal2Daniel Hachim3Department of Nephrology, School of Medicine, Faculty of Medicine, Pontificia Universidad CatólicaDepartment of Nephrology, School of Medicine, Faculty of Medicine, Pontificia Universidad CatólicaDepartment of Intensive Medicine, School of Medicine, Faculty of Medicine, Pontificia Universidad CatólicaDepartment of Pharmacy, School of Pharmacy, Faculty of Chemistry and Pharmacy, Pontificia Universidad Católica de ChileAbstract Hemodialysis, a cornerstone therapy for chronic kidney disease, represented a crucial advance in the evolution of artificial organs. While its success is largely due to its efficiency in removing uremic toxins, an equally important challenge is to uphold the primum non nocere principle by minimizing the harmful effects of membrane–blood interactions. This review examines the complex mechanisms and key interactions underlying membrane biocompatibility, including complement activation, inflammation, and coagulation disturbances, paving the way for their clinical implications. We also summarize recent innovations in membrane materials and surface engineering aimed at improving hemocompatibility and promoting safer hemodialysis treatments for improved clinical outcomes.https://doi.org/10.1186/s12882-025-04401-y |
| spellingShingle | Eduardo Ávila Rodrigo A. Sepúlveda Jaime Retamal Daniel Hachim Biocompatibility in hemodialysis: artificial membrane and human blood interactions BMC Nephrology |
| title | Biocompatibility in hemodialysis: artificial membrane and human blood interactions |
| title_full | Biocompatibility in hemodialysis: artificial membrane and human blood interactions |
| title_fullStr | Biocompatibility in hemodialysis: artificial membrane and human blood interactions |
| title_full_unstemmed | Biocompatibility in hemodialysis: artificial membrane and human blood interactions |
| title_short | Biocompatibility in hemodialysis: artificial membrane and human blood interactions |
| title_sort | biocompatibility in hemodialysis artificial membrane and human blood interactions |
| url | https://doi.org/10.1186/s12882-025-04401-y |
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