Knockout or inhibition of DHPS suppresses ovarian tumor growth and metastasis by attenuating the TGFβ pathway

Knockout or inhibition of DHPS suppresses ovarian tumor growth and metastasis by attenuating the TGFβ pathway

Abstract Deoxyhypusine synthase (DHPS) is an enzyme encoded by the DHPS gene, with high expression in various cancers, including ovarian cancer (OC). DHPS regulates the translation initiation factor EIF5A, and EIF5A2 knockout inhibits OC tumor growth and metastasis by blocking the epithelial-to-mese...

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Bibliographic Details
Main Authors: Guannan Zhao, Xinxin Zhao, Ziping Liu, Baojin Wang, Peixin Dong, Hidemichi Watari, Lawrence M. Pfeffer, Gabor Tigyi, Wenjing Zhang, Junming Yue
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
DHPS
EIF5A
Ovarian cancer
EMT
Metastasis
TGFβ
Online Access:https://doi.org/10.1038/s41598-025-85466-5
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