Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis
ObjectiveTo statistically analyze biomarkers predicting postoperative outcomes in children with congenital heart disease (CHD).MethodsPubMed, Embase, Cochrane Library, and Web of Science were performed to search up to February 2024. The measured outcomes were biomarkers, mortality, length of hospita...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1508329/full |
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| author | Shifan Zhou Shifan Zhou Lu Liu Xiaochuang Jin Daniel Dorikun Songfeng Ma |
| author_facet | Shifan Zhou Shifan Zhou Lu Liu Xiaochuang Jin Daniel Dorikun Songfeng Ma |
| author_sort | Shifan Zhou |
| collection | DOAJ |
| description | ObjectiveTo statistically analyze biomarkers predicting postoperative outcomes in children with congenital heart disease (CHD).MethodsPubMed, Embase, Cochrane Library, and Web of Science were performed to search up to February 2024. The measured outcomes were biomarkers, mortality, length of hospital stay, complication rates, and infection rates. Adults with CHD were excluded. Standard deviation or odds ratio (OR) with 95% confidence interval (95% CI) were extracted. A random-effects model synthesized SMDs or ORs with 95% CIs. Sensitivity analysis investigated heterogeneity, and Egger's test assessed publication bias.ResultsSeventeen eligible articles were included, the biomarkers involved include serum lactate, NT-Pro BNP, PaO2, serum creatinine, C1-INH activity, ST2, serum chloride concentration, GH, glycemia, cTOI, NLR, serum albumin, and glucose levels, with 2,888 patients who underwent surgery(modified Norwood procedure, arterial switch procedure, biventricular repair etc.). Serum lactate was higher in the postoperative death group (SMD: 1.18, 95% CI: 0.59–1.77). Lower postoperative N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels were associated with lower mortality (OR: 0.23, 95% CI: 0.08–0.68) and shorter mechanical ventilation time (OR: 0.40, 95% CI: 0.18–0.90). Higher serum albumin levels were associated with longer hospital stays (OR: 3.12, 95% CI: 1.66–5.84). Significant heterogeneity was found in serum creatinine, B-type natriuretic peptide (BNP), serum lactate, and NT-Pro BNP. Publication bias was detected in some studies.ConclusionSerum lactate, NT-Pro BNP, and serum albumin are reliable biomarkers for predicting adverse outcomes in children with CHD after surgery.Systematic Review RegistrationPROSPERO [CRD42024512753]. |
| format | Article |
| id | doaj-art-6341f97a82cb456184109fa622c67e35 |
| institution | Kabale University |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pediatrics |
| spelling | doaj-art-6341f97a82cb456184109fa622c67e352025-01-17T05:10:13ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-01-011310.3389/fped.2025.15083291508329Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysisShifan Zhou0Shifan Zhou1Lu Liu2Xiaochuang Jin3Daniel Dorikun4Songfeng Ma5Pediatric Cardiothoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaCollege of Pediatrics, Xinjiang Medical University, Urumqi, ChinaHematology Department, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaPediatric Cardiothoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaPediatric Cardiothoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaPediatric Cardiothoracic Surgery, First Affiliated Hospital of Xinjiang Medical University, Urumqi, ChinaObjectiveTo statistically analyze biomarkers predicting postoperative outcomes in children with congenital heart disease (CHD).MethodsPubMed, Embase, Cochrane Library, and Web of Science were performed to search up to February 2024. The measured outcomes were biomarkers, mortality, length of hospital stay, complication rates, and infection rates. Adults with CHD were excluded. Standard deviation or odds ratio (OR) with 95% confidence interval (95% CI) were extracted. A random-effects model synthesized SMDs or ORs with 95% CIs. Sensitivity analysis investigated heterogeneity, and Egger's test assessed publication bias.ResultsSeventeen eligible articles were included, the biomarkers involved include serum lactate, NT-Pro BNP, PaO2, serum creatinine, C1-INH activity, ST2, serum chloride concentration, GH, glycemia, cTOI, NLR, serum albumin, and glucose levels, with 2,888 patients who underwent surgery(modified Norwood procedure, arterial switch procedure, biventricular repair etc.). Serum lactate was higher in the postoperative death group (SMD: 1.18, 95% CI: 0.59–1.77). Lower postoperative N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels were associated with lower mortality (OR: 0.23, 95% CI: 0.08–0.68) and shorter mechanical ventilation time (OR: 0.40, 95% CI: 0.18–0.90). Higher serum albumin levels were associated with longer hospital stays (OR: 3.12, 95% CI: 1.66–5.84). Significant heterogeneity was found in serum creatinine, B-type natriuretic peptide (BNP), serum lactate, and NT-Pro BNP. Publication bias was detected in some studies.ConclusionSerum lactate, NT-Pro BNP, and serum albumin are reliable biomarkers for predicting adverse outcomes in children with CHD after surgery.Systematic Review RegistrationPROSPERO [CRD42024512753].https://www.frontiersin.org/articles/10.3389/fped.2025.1508329/fullcongenital heart disease (CHD)biomarkerspostoperative outcomesmetaanalysispediatric cardiac surgery |
| spellingShingle | Shifan Zhou Shifan Zhou Lu Liu Xiaochuang Jin Daniel Dorikun Songfeng Ma Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis Frontiers in Pediatrics congenital heart disease (CHD) biomarkers postoperative outcomes metaanalysis pediatric cardiac surgery |
| title | Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis |
| title_full | Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis |
| title_fullStr | Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis |
| title_full_unstemmed | Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis |
| title_short | Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis |
| title_sort | biomarkers predicting postoperative adverse outcomes in children with congenital heart disease a systematic review and meta analysis |
| topic | congenital heart disease (CHD) biomarkers postoperative outcomes metaanalysis pediatric cardiac surgery |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1508329/full |
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