Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens
BackgroundThis study aimed to assess the distribution of bacteremia pathogens in elderly patients, examine the impact of gender on pathogen distribution, and evaluate the predictive value of routine blood parameters for diagnosing bacteremia.MethodsA retrospective analysis was conducted on 151 elder...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1472765/full |
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| author | Shi-Yan Zhang Ying Zhuo Bu-Ren Li Ying-Ying Jiang Jie Zhang Na Cai Lin Yang |
| author_facet | Shi-Yan Zhang Ying Zhuo Bu-Ren Li Ying-Ying Jiang Jie Zhang Na Cai Lin Yang |
| author_sort | Shi-Yan Zhang |
| collection | DOAJ |
| description | BackgroundThis study aimed to assess the distribution of bacteremia pathogens in elderly patients, examine the impact of gender on pathogen distribution, and evaluate the predictive value of routine blood parameters for diagnosing bacteremia.MethodsA retrospective analysis was conducted on 151 elderly patients (≥60 years old) admitted to Fuding Hospital, Fujian University of Traditional Chinese Medicine between October 2022 and June 2023. Comprehensive routine blood tests and blood cultures were performed. The diagnostic efficacy of routine blood parameters, including white blood cell (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red blood cell distribution width (RDW), was evaluated using receive operating characteristic (ROC) curve analysis. Patients were categorized into either the culture-positive group (82 cases) or the culture-negative group (69 cases) according to blood culture results.ResultsNo significant differences in age and gender were found between the culture-positive and culture-negative groups. The primary bacterial pathogens of bacteremia in the elderly were Escherichia coli, Klebsiella pneumoniae and Streptococcus. Elderly female patients demonstrated a significantly higher culture positivity rate for E. coli compared to their male counterparts (P = 0.021). The areas under the ROC curve (AUC) for the four parameters were as follows: WBC, 0.851 (95% confidence interval (CI) 0.790 - 0.912); NLR, 0.919 (95% CI 0.875 - 0.963); PLR, 0.609 (95% CI 0.518 - 0.700); and RDW was 0.626 (95% CI 0.563 - 0.717).ConclusionsE. coli was identified as the predominant pathogenic microorganism causing bacteremia in the elderly, with a significantly higher culture positivity rate among female patients. Routine blood parameters (WBC, NLR, PLR, and RDW) demonstrated a predictive potential for diagnosing bacteremia in elderly patients. |
| format | Article |
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| institution | Kabale University |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-631c31414e4e47d98822fe873990e98f2025-01-16T06:10:32ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-01-011410.3389/fcimb.2024.14727651472765Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogensShi-Yan ZhangYing ZhuoBu-Ren LiYing-Ying JiangJie ZhangNa CaiLin YangBackgroundThis study aimed to assess the distribution of bacteremia pathogens in elderly patients, examine the impact of gender on pathogen distribution, and evaluate the predictive value of routine blood parameters for diagnosing bacteremia.MethodsA retrospective analysis was conducted on 151 elderly patients (≥60 years old) admitted to Fuding Hospital, Fujian University of Traditional Chinese Medicine between October 2022 and June 2023. Comprehensive routine blood tests and blood cultures were performed. The diagnostic efficacy of routine blood parameters, including white blood cell (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and red blood cell distribution width (RDW), was evaluated using receive operating characteristic (ROC) curve analysis. Patients were categorized into either the culture-positive group (82 cases) or the culture-negative group (69 cases) according to blood culture results.ResultsNo significant differences in age and gender were found between the culture-positive and culture-negative groups. The primary bacterial pathogens of bacteremia in the elderly were Escherichia coli, Klebsiella pneumoniae and Streptococcus. Elderly female patients demonstrated a significantly higher culture positivity rate for E. coli compared to their male counterparts (P = 0.021). The areas under the ROC curve (AUC) for the four parameters were as follows: WBC, 0.851 (95% confidence interval (CI) 0.790 - 0.912); NLR, 0.919 (95% CI 0.875 - 0.963); PLR, 0.609 (95% CI 0.518 - 0.700); and RDW was 0.626 (95% CI 0.563 - 0.717).ConclusionsE. coli was identified as the predominant pathogenic microorganism causing bacteremia in the elderly, with a significantly higher culture positivity rate among female patients. Routine blood parameters (WBC, NLR, PLR, and RDW) demonstrated a predictive potential for diagnosing bacteremia in elderly patients.https://www.frontiersin.org/articles/10.3389/fcimb.2024.1472765/fullelderlyblood cultureneutrophil-to-lymphocyte ratioROC analysisEscherichia colibacteremia |
| spellingShingle | Shi-Yan Zhang Ying Zhuo Bu-Ren Li Ying-Ying Jiang Jie Zhang Na Cai Lin Yang Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens Frontiers in Cellular and Infection Microbiology elderly blood culture neutrophil-to-lymphocyte ratio ROC analysis Escherichia coli bacteremia |
| title | Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens |
| title_full | Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens |
| title_fullStr | Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens |
| title_full_unstemmed | Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens |
| title_short | Identifying key blood markers for bacteremia in elderly patients: insights into bacterial pathogens |
| title_sort | identifying key blood markers for bacteremia in elderly patients insights into bacterial pathogens |
| topic | elderly blood culture neutrophil-to-lymphocyte ratio ROC analysis Escherichia coli bacteremia |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2024.1472765/full |
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