Accurate diagnosis of ischemic heart disease without exposure to radiation using non-stress unshielded magnetocardiography
Study objectives: To evaluate the capability and accuracy of magnetocardiography (MCG) to identify patients with ischemic chest pain from those with non-ischemic pain and to verify normalcy in the MCG in healthy subjects. Design: We studied 133 patients (mean age 59 ± 14 years, 69 % male) with chron...
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Elsevier
2025-01-01
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| Series: | American Heart Journal Plus |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602224001265 |
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| author | Kirsten Tolstrup Massoud Akhtari Donatella Brisinda Anna M. Meloni Robert J. Siegel Riccardo Fenici |
| author_facet | Kirsten Tolstrup Massoud Akhtari Donatella Brisinda Anna M. Meloni Robert J. Siegel Riccardo Fenici |
| author_sort | Kirsten Tolstrup |
| collection | DOAJ |
| description | Study objectives: To evaluate the capability and accuracy of magnetocardiography (MCG) to identify patients with ischemic chest pain from those with non-ischemic pain and to verify normalcy in the MCG in healthy subjects. Design: We studied 133 patients (mean age 59 ± 14 years, 69 % male) with chronic or acute chest pain syndrome and 63 healthy subjects (mean age 41.7 ± 12.2 years, 51 % male) using unshielded cryogenically cooled MCG systems (Cardiomag Imaging Inc., 9 and 36 channels) in a general clinical setting. Scan time was 90 s to 6 min. Interventions: The MCG data were processed with the same automated analysis software and results were immediately available. All patients were chest pain free at the time of scanning. Results: A diagnosis of ischemic chest pain was established in 41 % after non-invasive and invasive testing. Rest MCG was normal in all healthy subjects. An abnormal rest MCG was strongly associated with ischemic chest pain, p < 0.0001 (sensitivity of 86 %, specificity of 80 %, positive (PPV) and negative predictive value (NPV) of 75 % and 89 %, respectively). In comparison, the sensitivity, specificity, PPV and NPV of stress SPECT was 93 %, 72 %, 77 % and 91 %, respectively. Conclusion: Resting MCG is a rapid risk-free method for the detection of ischemic chest pain without the use of radiation or contrast with results comparable with stress SPECT. |
| format | Article |
| id | doaj-art-631b0b133e6b4b8f846297a2dd15df12 |
| institution | Kabale University |
| issn | 2666-6022 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj-art-631b0b133e6b4b8f846297a2dd15df122025-01-07T04:17:31ZengElsevierAmerican Heart Journal Plus2666-60222025-01-0149100483Accurate diagnosis of ischemic heart disease without exposure to radiation using non-stress unshielded magnetocardiographyKirsten Tolstrup0Massoud Akhtari1Donatella Brisinda2Anna M. Meloni3Robert J. Siegel4Riccardo Fenici5UCSF Medical Center, Division of Cardiology, San Francisco, USA; Corresponding author at: UCSF Medical Center, Box 0214, 505 Parnassus Ave, San Francisco, CA 94143, USA.Nanomersion Inc, USACatholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, ItalyCatholic University of the Sacred Heart, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, Rome, ItalyCedars-Sinai Heart Institute, Division of Cardiology, Los Angeles, USABiomagnetism and Clinical Physiology International Center, Rome, ItalyStudy objectives: To evaluate the capability and accuracy of magnetocardiography (MCG) to identify patients with ischemic chest pain from those with non-ischemic pain and to verify normalcy in the MCG in healthy subjects. Design: We studied 133 patients (mean age 59 ± 14 years, 69 % male) with chronic or acute chest pain syndrome and 63 healthy subjects (mean age 41.7 ± 12.2 years, 51 % male) using unshielded cryogenically cooled MCG systems (Cardiomag Imaging Inc., 9 and 36 channels) in a general clinical setting. Scan time was 90 s to 6 min. Interventions: The MCG data were processed with the same automated analysis software and results were immediately available. All patients were chest pain free at the time of scanning. Results: A diagnosis of ischemic chest pain was established in 41 % after non-invasive and invasive testing. Rest MCG was normal in all healthy subjects. An abnormal rest MCG was strongly associated with ischemic chest pain, p < 0.0001 (sensitivity of 86 %, specificity of 80 %, positive (PPV) and negative predictive value (NPV) of 75 % and 89 %, respectively). In comparison, the sensitivity, specificity, PPV and NPV of stress SPECT was 93 %, 72 %, 77 % and 91 %, respectively. Conclusion: Resting MCG is a rapid risk-free method for the detection of ischemic chest pain without the use of radiation or contrast with results comparable with stress SPECT.http://www.sciencedirect.com/science/article/pii/S2666602224001265IschemiaCoronary artery diseaseAnginaMagnetocardiography |
| spellingShingle | Kirsten Tolstrup Massoud Akhtari Donatella Brisinda Anna M. Meloni Robert J. Siegel Riccardo Fenici Accurate diagnosis of ischemic heart disease without exposure to radiation using non-stress unshielded magnetocardiography American Heart Journal Plus Ischemia Coronary artery disease Angina Magnetocardiography |
| title | Accurate diagnosis of ischemic heart disease without exposure to radiation using non-stress unshielded magnetocardiography |
| title_full | Accurate diagnosis of ischemic heart disease without exposure to radiation using non-stress unshielded magnetocardiography |
| title_fullStr | Accurate diagnosis of ischemic heart disease without exposure to radiation using non-stress unshielded magnetocardiography |
| title_full_unstemmed | Accurate diagnosis of ischemic heart disease without exposure to radiation using non-stress unshielded magnetocardiography |
| title_short | Accurate diagnosis of ischemic heart disease without exposure to radiation using non-stress unshielded magnetocardiography |
| title_sort | accurate diagnosis of ischemic heart disease without exposure to radiation using non stress unshielded magnetocardiography |
| topic | Ischemia Coronary artery disease Angina Magnetocardiography |
| url | http://www.sciencedirect.com/science/article/pii/S2666602224001265 |
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