Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavities
Local steroid medication is one of the most important treatment options for chronic rhinosinusitis. Regional deposition has a higher clinical value compared with total deposition in predicting treatment outcomes or evaluating adverse reactions. The goal of this project is to propose an effective tec...
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Elsevier
2024-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024142107 |
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| author | Wei He Muhan Shi Yaozhong Lu Chengsheng Chu Xiaolong Wang Min Wang Xiaofang Zhang |
| author_facet | Wei He Muhan Shi Yaozhong Lu Chengsheng Chu Xiaolong Wang Min Wang Xiaofang Zhang |
| author_sort | Wei He |
| collection | DOAJ |
| description | Local steroid medication is one of the most important treatment options for chronic rhinosinusitis. Regional deposition has a higher clinical value compared with total deposition in predicting treatment outcomes or evaluating adverse reactions. The goal of this project is to propose an effective technique for visualizing and quantifying aerosol deposition in a three-dimensional adult nasal cavity, and to verify the practicality of this method. Three-dimensional (3D) nasal cavity models were constructed from computed tomography (CT) scans of one post-operative rhinosinusitis subject using imaging software. The nasal cast was coated with a water-indicating paste and deposited with saline; a liquid dressing was added to visualize the progress. The quantity of liquid dressing was evaluated via HPLC and the liquid deposition was analyzed within the nasal cast cavity. Herein, 98.77 % of the particles generated by the nebulizer were over 5 μm, suggesting that most of the aerosol could effectively enter the nasal cavity instead of the lower respiratory system. The liquid dressing was mainly deposited in the nasal cavity, ethmoid sinus, and frontal sinus according to the visualization tests. HPLC results suggested that the main deposits were the frontal sinus (up to 41.80 %) as well as in the sphenoid sinus and ethmoid sinus (14.00 %). The large particle nebulizer (BM-TCA) generally led to better deposition in sinus areas when compared to the smaller particle nebulizer (PARI). This technology allows for in vitro testing of various types of nasal preparations and equipment under various test methods. |
| format | Article |
| id | doaj-art-62f65d5b7cf14dfc8bbca33d501eed19 |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-62f65d5b7cf14dfc8bbca33d501eed192024-11-15T06:12:17ZengElsevierHeliyon2405-84402024-11-011021e38179Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavitiesWei He0Muhan Shi1Yaozhong Lu2Chengsheng Chu3Xiaolong Wang4Min Wang5Xiaofang Zhang6Breath Medical Co., Ltd., Hefei, PR ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, Xi Zhi Men Nan Da Jie 11#, Beijing, 100044, PR ChinaLanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No.18, Tianshui Middle Road, Lanzhou, PR ChinaBreath Medical Co., Ltd., Hefei, PR ChinaLanzhou Institute of Chemical Physics, Chinese Academy of Sciences, No.18, Tianshui Middle Road, Lanzhou, PR ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Peking University People's Hospital, Xi Zhi Men Nan Da Jie 11#, Beijing, 100044, PR China; Corresponding author.Breath Medical Co., Ltd., Hefei, PR China; Corresponding author. Breath Medical Co., Ltd., No. 100 Kongquetai Road, High-tech Zone, Hefei, 230041, PR China.Local steroid medication is one of the most important treatment options for chronic rhinosinusitis. Regional deposition has a higher clinical value compared with total deposition in predicting treatment outcomes or evaluating adverse reactions. The goal of this project is to propose an effective technique for visualizing and quantifying aerosol deposition in a three-dimensional adult nasal cavity, and to verify the practicality of this method. Three-dimensional (3D) nasal cavity models were constructed from computed tomography (CT) scans of one post-operative rhinosinusitis subject using imaging software. The nasal cast was coated with a water-indicating paste and deposited with saline; a liquid dressing was added to visualize the progress. The quantity of liquid dressing was evaluated via HPLC and the liquid deposition was analyzed within the nasal cast cavity. Herein, 98.77 % of the particles generated by the nebulizer were over 5 μm, suggesting that most of the aerosol could effectively enter the nasal cavity instead of the lower respiratory system. The liquid dressing was mainly deposited in the nasal cavity, ethmoid sinus, and frontal sinus according to the visualization tests. HPLC results suggested that the main deposits were the frontal sinus (up to 41.80 %) as well as in the sphenoid sinus and ethmoid sinus (14.00 %). The large particle nebulizer (BM-TCA) generally led to better deposition in sinus areas when compared to the smaller particle nebulizer (PARI). This technology allows for in vitro testing of various types of nasal preparations and equipment under various test methods.http://www.sciencedirect.com/science/article/pii/S24058440241421073D nasal cavityVisualizationQuantitative evaluationAerosol depositionDrug delivery technique |
| spellingShingle | Wei He Muhan Shi Yaozhong Lu Chengsheng Chu Xiaolong Wang Min Wang Xiaofang Zhang Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavities Heliyon 3D nasal cavity Visualization Quantitative evaluation Aerosol deposition Drug delivery technique |
| title | Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavities |
| title_full | Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavities |
| title_fullStr | Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavities |
| title_full_unstemmed | Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavities |
| title_short | Visualization and quantitative evaluation of aerosol deposition using 3D-printed adult nose cavities |
| title_sort | visualization and quantitative evaluation of aerosol deposition using 3d printed adult nose cavities |
| topic | 3D nasal cavity Visualization Quantitative evaluation Aerosol deposition Drug delivery technique |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024142107 |
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