Extracellular matrix re-normalization to improve cold tumor penetration by oncolytic viruses

Extracellular matrix re-normalization to improve cold tumor penetration by oncolytic viruses

Immunologically inert or cold tumors pose a substantial challenge to the effectiveness of immunotherapy. The use of oncolytic viruses (OVs) to induce immunogenic cell death (ICD) in tumor cells is a well-established strategy for initiating the cancer immunity cycle (CIC). This process promotes the t...

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Bibliographic Details
Main Authors: Geofrey F. Soko, Benson K. Kosgei, Stephene S. Meena, Ying Jing Ng, Huihui Liang, Bing Zhang, Qingjun Liu, Tielong Xu, Xinju Hou, Ray P. S. Han
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
cold tumors
tumor immune microenvironment
immunotherapy
oncolytic viruses
tumor-infiltrating immune cells
tumor ECM barriers
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1535647/full
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