Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD

Integrative scRNA-seq and transcriptomic analysis initially reveals monocyte/macrophage activation drives EV-A71-induced immune dysregulation and neural injury in severe HFMD

ObjectiveEnterovirus 71 (EV-A71) is a major pathogen of severe hand, foot and mouth disease (HFMD) in children, but the mechanism by which it develops into severe HFMD remains unclear, especially the role of macrophage-mediated immune dysregulation.MethodsBioinformatics tools were utilized to analyz...

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Bibliographic Details
Main Authors: Muqi Wang, Meng Zhang, Huiling Deng, Yufeng Zhang, Chenrui Liu, Yuan Chen, Chuting Zhang, Wen Zhang, Xiaoli Jia, Shuangsuo Dang, Yaping Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
EV-A71
innate immunity
monocyte/macrophages
severe HFMD
nerve damage
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1620633/full
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