Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review
Peripheral neuropathy is a common cause of morbidity in diabetes. Despite recent advancements in early diagnosis methods, there is a need for practical, highly sensitive, and cost-effective screening methods in clinical practice. This study summarizes evidence from systematic reviews and meta-analys...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/jdr/5902036 |
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| author | María Mogilevskaya Mariana Gaviria-Carrillo John Edwin Feliciano-Alfonso Ana M. Barragan Carlos A. Calderon-Ospina Mauricio O. Nava-Mesa |
| author_facet | María Mogilevskaya Mariana Gaviria-Carrillo John Edwin Feliciano-Alfonso Ana M. Barragan Carlos A. Calderon-Ospina Mauricio O. Nava-Mesa |
| author_sort | María Mogilevskaya |
| collection | DOAJ |
| description | Peripheral neuropathy is a common cause of morbidity in diabetes. Despite recent advancements in early diagnosis methods, there is a need for practical, highly sensitive, and cost-effective screening methods in clinical practice. This study summarizes evidence from systematic reviews and meta-analyses on the diagnostic accuracy of validated screening methods for diabetic peripheral neuropathy. Two independent reviewers assessed methodological quality and bias using AMSTAR and ROBIS tools. Seven reviews with 19,531 participants were included. The monofilament test showed inconsistent sensitivity (S: 0.53–0.93) and specificity (Sp: 0.64–1.00), along with high variability in its application. Neuropad exhibited high S (86%, 95% CI 79–91). However, variations in the interpretation of results across the included studies may have impacted its Sp (65%, 95% CI 51–76). The Ipswich touch test exhibited adequate diagnostic accuracy (S: 0.77, Sp: 0.96, DOR: 75.24) but lacked comparison with gold standard tests. In vibration perception studies, the biothesiometer outperformed the tuning fork (S: 0.61–0.80 vs. 0.10–0.46). In general, heterogeneity was observed due to varied reference tests, thresholds, and patient differences. The development of automated analysis methods, as well as determination of predictive value of the combination of screening tools, is needed for further studies. Based on the study results, we suggest that clinicians should select screening tools tailored to their patient population, clinical setting, and available resources, as no single test can be universally recommended for all clinical scenarios. |
| format | Article |
| id | doaj-art-62d838601d28459ebcb49e5d8fbc38d6 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-62d838601d28459ebcb49e5d8fbc38d62024-12-12T00:00:05ZengWileyJournal of Diabetes Research2314-67532024-01-01202410.1155/jdr/5902036Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella ReviewMaría Mogilevskaya0Mariana Gaviria-Carrillo1John Edwin Feliciano-Alfonso2Ana M. Barragan3Carlos A. Calderon-Ospina4Mauricio O. Nava-Mesa5Neuroscience Research Group (NeURos)Neuroscience Research Group (NeURos)Internal Medicine DepartmentPublic Health Research GroupSchool of Medicine and Health SciencesNeuroscience Research Group (NeURos)Peripheral neuropathy is a common cause of morbidity in diabetes. Despite recent advancements in early diagnosis methods, there is a need for practical, highly sensitive, and cost-effective screening methods in clinical practice. This study summarizes evidence from systematic reviews and meta-analyses on the diagnostic accuracy of validated screening methods for diabetic peripheral neuropathy. Two independent reviewers assessed methodological quality and bias using AMSTAR and ROBIS tools. Seven reviews with 19,531 participants were included. The monofilament test showed inconsistent sensitivity (S: 0.53–0.93) and specificity (Sp: 0.64–1.00), along with high variability in its application. Neuropad exhibited high S (86%, 95% CI 79–91). However, variations in the interpretation of results across the included studies may have impacted its Sp (65%, 95% CI 51–76). The Ipswich touch test exhibited adequate diagnostic accuracy (S: 0.77, Sp: 0.96, DOR: 75.24) but lacked comparison with gold standard tests. In vibration perception studies, the biothesiometer outperformed the tuning fork (S: 0.61–0.80 vs. 0.10–0.46). In general, heterogeneity was observed due to varied reference tests, thresholds, and patient differences. The development of automated analysis methods, as well as determination of predictive value of the combination of screening tools, is needed for further studies. Based on the study results, we suggest that clinicians should select screening tools tailored to their patient population, clinical setting, and available resources, as no single test can be universally recommended for all clinical scenarios.http://dx.doi.org/10.1155/jdr/5902036 |
| spellingShingle | María Mogilevskaya Mariana Gaviria-Carrillo John Edwin Feliciano-Alfonso Ana M. Barragan Carlos A. Calderon-Ospina Mauricio O. Nava-Mesa Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review Journal of Diabetes Research |
| title | Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review |
| title_full | Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review |
| title_fullStr | Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review |
| title_full_unstemmed | Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review |
| title_short | Diagnostic Accuracy of Screening Tests for Diabetic Peripheral Neuropathy: An Umbrella Review |
| title_sort | diagnostic accuracy of screening tests for diabetic peripheral neuropathy an umbrella review |
| url | http://dx.doi.org/10.1155/jdr/5902036 |
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