Photo- and electro-chemical strategies for indazole synthesis
The indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential in medicinal chemistry and drug discovery, which therefore has attracted sustained attention from the synthetic community. Over the recent decades, significant progress has been achieve...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Tetrahedron Chem |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666951X2400055X |
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| author | Binbin Huang |
| author_facet | Binbin Huang |
| author_sort | Binbin Huang |
| collection | DOAJ |
| description | The indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential in medicinal chemistry and drug discovery, which therefore has attracted sustained attention from the synthetic community. Over the recent decades, significant progress has been achieved in both organic photocatalysis and electrosynthesis, offering novel approaches for the efficient and sustainable synthesis of various functionalized indazoles. This mini-review highlights the emerging methodological advancements in photo-/electro-chemical synthesis of two common forms of indazole, namely 1H- and 2H-indazoles, which are classified by specific intramolecular bond formation patterns: (1) C–C bond formation, (2) C–N bond formation, and (3) N–N bond formation. The reaction conditions, representative scopes, and mechanistic understandings of these protocols are emphasized, to elucidate the advantages and limitations in current strategies, with an aim to inspire future innovations that may address challenges in modern indazole synthesis. |
| format | Article |
| id | doaj-art-62cddb0bb8a94a0395d2492c2c15ba13 |
| institution | Kabale University |
| issn | 2666-951X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Tetrahedron Chem |
| spelling | doaj-art-62cddb0bb8a94a0395d2492c2c15ba132024-12-16T05:38:30ZengElsevierTetrahedron Chem2666-951X2024-12-0112100116Photo- and electro-chemical strategies for indazole synthesisBinbin Huang0Faculty of Arts and Sciences, Beijing Normal University, Zhuhai, 519085, ChinaThe indazole core is prevalently found in the structures of bioactive molecules, demonstrating promising potential in medicinal chemistry and drug discovery, which therefore has attracted sustained attention from the synthetic community. Over the recent decades, significant progress has been achieved in both organic photocatalysis and electrosynthesis, offering novel approaches for the efficient and sustainable synthesis of various functionalized indazoles. This mini-review highlights the emerging methodological advancements in photo-/electro-chemical synthesis of two common forms of indazole, namely 1H- and 2H-indazoles, which are classified by specific intramolecular bond formation patterns: (1) C–C bond formation, (2) C–N bond formation, and (3) N–N bond formation. The reaction conditions, representative scopes, and mechanistic understandings of these protocols are emphasized, to elucidate the advantages and limitations in current strategies, with an aim to inspire future innovations that may address challenges in modern indazole synthesis.http://www.sciencedirect.com/science/article/pii/S2666951X2400055XIndazole synthesisOrganic photocatalysisOrganic electrosynthesisCross dehydrogenative couplingDeoxygenative cyclizationRadical cyclization |
| spellingShingle | Binbin Huang Photo- and electro-chemical strategies for indazole synthesis Tetrahedron Chem Indazole synthesis Organic photocatalysis Organic electrosynthesis Cross dehydrogenative coupling Deoxygenative cyclization Radical cyclization |
| title | Photo- and electro-chemical strategies for indazole synthesis |
| title_full | Photo- and electro-chemical strategies for indazole synthesis |
| title_fullStr | Photo- and electro-chemical strategies for indazole synthesis |
| title_full_unstemmed | Photo- and electro-chemical strategies for indazole synthesis |
| title_short | Photo- and electro-chemical strategies for indazole synthesis |
| title_sort | photo and electro chemical strategies for indazole synthesis |
| topic | Indazole synthesis Organic photocatalysis Organic electrosynthesis Cross dehydrogenative coupling Deoxygenative cyclization Radical cyclization |
| url | http://www.sciencedirect.com/science/article/pii/S2666951X2400055X |
| work_keys_str_mv | AT binbinhuang photoandelectrochemicalstrategiesforindazolesynthesis |