Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia
Acute Myeloid Leukemia (AML) is one of the most aggressive hematological malignancies. It has a highly heterogeneous genetic background and complex clonal evolution. In this letter, we emphasized the prognostic importance of a crucial biomarker in acute myeloid leukemia (AML) – the Fms - like tyrosi...
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Sakarya University
2024-12-01
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| Series: | Sakarya Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/4413483 |
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| author | Ayşe Gül Bayrak Tokaç Aynur Dağlar Aday |
| author_facet | Ayşe Gül Bayrak Tokaç Aynur Dağlar Aday |
| author_sort | Ayşe Gül Bayrak Tokaç |
| collection | DOAJ |
| description | Acute Myeloid Leukemia (AML) is one of the most aggressive hematological malignancies. It has a highly heterogeneous genetic background and complex clonal evolution. In this letter, we emphasized the prognostic importance of a crucial biomarker in acute myeloid leukemia (AML) – the Fms - like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase that plays a significant role in several cellular signalling processes. FLT3 is found on hematopoietic stem cells and early progenitor cells. After binding to its ligand, activated FLT3 triggers intracellular kinase, leads to cellular proliferation, and inhibits differentiation and apoptosis. |
| format | Article |
| id | doaj-art-62ae2fdc495547d59744038bf11ed81c |
| institution | Kabale University |
| issn | 2146-409X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Sakarya University |
| record_format | Article |
| series | Sakarya Tıp Dergisi |
| spelling | doaj-art-62ae2fdc495547d59744038bf11ed81c2025-01-07T09:05:44ZengSakarya UniversitySakarya Tıp Dergisi2146-409X2024-12-0114443343410.31832/smj.159559728Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid LeukemiaAyşe Gül Bayrak Tokaç0https://orcid.org/0000-0003-2228-0632Aynur Dağlar Aday1https://orcid.org/0000-0001-8072-0646İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİ, İSTANBUL TIP PR.İSTANBUL ÜNİVERSİTESİ, İSTANBUL TIP FAKÜLTESİAcute Myeloid Leukemia (AML) is one of the most aggressive hematological malignancies. It has a highly heterogeneous genetic background and complex clonal evolution. In this letter, we emphasized the prognostic importance of a crucial biomarker in acute myeloid leukemia (AML) – the Fms - like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase that plays a significant role in several cellular signalling processes. FLT3 is found on hematopoietic stem cells and early progenitor cells. After binding to its ligand, activated FLT3 triggers intracellular kinase, leads to cellular proliferation, and inhibits differentiation and apoptosis.https://dergipark.org.tr/tr/download/article-file/4413483flt3mutasyonakut myeloid lösemiflt3mutationacute myeloid leukemia |
| spellingShingle | Ayşe Gül Bayrak Tokaç Aynur Dağlar Aday Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia Sakarya Tıp Dergisi flt3 mutasyon akut myeloid lösemi flt3 mutation acute myeloid leukemia |
| title | Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia |
| title_full | Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia |
| title_fullStr | Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia |
| title_full_unstemmed | Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia |
| title_short | Overview of Prognosis of FLT3 Mutations and Interactions with Other Genetic Alterations in Acute Myeloid Leukemia |
| title_sort | overview of prognosis of flt3 mutations and interactions with other genetic alterations in acute myeloid leukemia |
| topic | flt3 mutasyon akut myeloid lösemi flt3 mutation acute myeloid leukemia |
| url | https://dergipark.org.tr/tr/download/article-file/4413483 |
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