Upregulation of CD244 promotes CD8+ T cell exhaustion in patients with alveolar echinococcosis and a murine model

Upregulation of CD244 promotes CD8+ T cell exhaustion in patients with alveolar echinococcosis and a murine model

Abstract Background In patients with alveolar echinococcosis (AE), CD8+ T cells undergo functional exhaustion, which accelerates the malignant progression of AE. However, the role of inhibitory receptor CD244 in mediating CD8+ T cell exhaustion remains elusive. Methods CD244 expression on exhausted...

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Main Authors: Maolin Wang, Bingqing Deng, Tiemin Jiang, Adilai Duolikun, Yinshi Li, Abidan ainiwaer, Xuejiao Kang, Xuran Zheng, Zibigu Rousu, Qian Yu, Jing Li, Hui Wang, Chuanshan Zhang, Tuerganaili Aji, Yingmei Shao
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Parasites & Vectors
Subjects:
Alveolar echinococcosis
CD8
Immune exhaustion
CD244
Online Access:https://doi.org/10.1186/s13071-024-06573-2
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https://doi.org/10.1186/s13071-024-06573-2

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