Age-related alterations in gut homeostasis are microbiota dependent
Abstract Accumulating data suggest that remodeling aged gut microbiota improves aging-related imbalance in intestinal homeostasis. However, evidence in favor of the beneficial effect of remodeling gut microbiota on intestinal stress and immune responses during aging is scarce. The current study reve...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-03-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-025-00677-y |
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| author | Yingli Jing Qiuying Wang Fan Bai Zihan Li Yan Li Weijin Liu Yitong Yan Shuangyue Zhang Chen Gao Yan Yu |
| author_facet | Yingli Jing Qiuying Wang Fan Bai Zihan Li Yan Li Weijin Liu Yitong Yan Shuangyue Zhang Chen Gao Yan Yu |
| author_sort | Yingli Jing |
| collection | DOAJ |
| description | Abstract Accumulating data suggest that remodeling aged gut microbiota improves aging-related imbalance in intestinal homeostasis. However, evidence in favor of the beneficial effect of remodeling gut microbiota on intestinal stress and immune responses during aging is scarce. The current study revealed that old mice presented impaired gut barrier integrity. Transcriptome sequencing coupled with bioinformatics analysis revealed that aging altered gene expression profiles of the colon and mesenteric lymph nodes, which are involved mainly in stress and immune responses, respectively. Notably, gut microbiota was closely related to the differentially expressed genes. Microbiota depletion in old mice ameliorated gut barrier integrity and partially reversed the inflammatory factors upregulated in aging mice. Furthermore, fecal microbiota transplantation from young mice to old mice resulted in a significant improvement in intestinal barrier integrity and immune homeostasis. These findings highlight the potential of microbiota-targeted interventions on aging-related physiological processes and call for further investigation. |
| format | Article |
| id | doaj-art-627c72346df84b51b0e8d7f2b7976f95 |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-627c72346df84b51b0e8d7f2b7976f952025-08-20T03:40:50ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-03-0111111410.1038/s41522-025-00677-yAge-related alterations in gut homeostasis are microbiota dependentYingli Jing0Qiuying Wang1Fan Bai2Zihan Li3Yan Li4Weijin Liu5Yitong Yan6Shuangyue Zhang7Chen Gao8Yan Yu9China Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityChina Rehabilitation Science Institute, China Rehabilitation Research Center, Beijing Key Laboratory of Neural Injury and Rehabilitation, and School of Rehabilitation Medicine, Capital Medical UniversityAbstract Accumulating data suggest that remodeling aged gut microbiota improves aging-related imbalance in intestinal homeostasis. However, evidence in favor of the beneficial effect of remodeling gut microbiota on intestinal stress and immune responses during aging is scarce. The current study revealed that old mice presented impaired gut barrier integrity. Transcriptome sequencing coupled with bioinformatics analysis revealed that aging altered gene expression profiles of the colon and mesenteric lymph nodes, which are involved mainly in stress and immune responses, respectively. Notably, gut microbiota was closely related to the differentially expressed genes. Microbiota depletion in old mice ameliorated gut barrier integrity and partially reversed the inflammatory factors upregulated in aging mice. Furthermore, fecal microbiota transplantation from young mice to old mice resulted in a significant improvement in intestinal barrier integrity and immune homeostasis. These findings highlight the potential of microbiota-targeted interventions on aging-related physiological processes and call for further investigation.https://doi.org/10.1038/s41522-025-00677-y |
| spellingShingle | Yingli Jing Qiuying Wang Fan Bai Zihan Li Yan Li Weijin Liu Yitong Yan Shuangyue Zhang Chen Gao Yan Yu Age-related alterations in gut homeostasis are microbiota dependent npj Biofilms and Microbiomes |
| title | Age-related alterations in gut homeostasis are microbiota dependent |
| title_full | Age-related alterations in gut homeostasis are microbiota dependent |
| title_fullStr | Age-related alterations in gut homeostasis are microbiota dependent |
| title_full_unstemmed | Age-related alterations in gut homeostasis are microbiota dependent |
| title_short | Age-related alterations in gut homeostasis are microbiota dependent |
| title_sort | age related alterations in gut homeostasis are microbiota dependent |
| url | https://doi.org/10.1038/s41522-025-00677-y |
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