Dysregulated Coagulation in Parkinson’s Disease
Parkinson’s disease (PD), a prevalent neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein accumulation, has been increasingly associated with coagulation dysfunction. This review synthesizes emerging evidence linking dysregulated coagulation to PD pathophysio...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/13/22/1874 |
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| author | Xinqing Wang Wenxin Li Xinyue Zhao Ning Hu Xi Wang Xilin Xiao Kai Yang Taolei Sun |
| author_facet | Xinqing Wang Wenxin Li Xinyue Zhao Ning Hu Xi Wang Xilin Xiao Kai Yang Taolei Sun |
| author_sort | Xinqing Wang |
| collection | DOAJ |
| description | Parkinson’s disease (PD), a prevalent neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein accumulation, has been increasingly associated with coagulation dysfunction. This review synthesizes emerging evidence linking dysregulated coagulation to PD pathophysiology. We examine the alterations in coagulation parameters, including elevated fibrinogen levels, impaired fibrinolysis, and platelet dysfunction, which collectively contribute to a hypercoagulable state in PD patients. Epidemiological studies have revealed a higher incidence of thrombotic events, such as deep vein thrombosis (DVT) and stroke, among PD patients, suggesting significant comorbidity between PD and coagulation disorders. This review explores the potential pathophysiological mechanisms underlying this association, focusing on the roles of inflammation and oxidative stress. Additionally, we discuss the limitations of current research and propose future directions. This comprehensive analysis underscores the importance of understanding the coagulation–neurodegeneration axis in PD, which may lead to novel diagnostic and therapeutic strategies for this debilitating condition. |
| format | Article |
| id | doaj-art-624c7668c0cb4f52b8f3551b63c2f4e7 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-624c7668c0cb4f52b8f3551b63c2f4e72024-11-26T17:56:53ZengMDPI AGCells2073-44092024-11-011322187410.3390/cells13221874Dysregulated Coagulation in Parkinson’s DiseaseXinqing Wang0Wenxin Li1Xinyue Zhao2Ning Hu3Xi Wang4Xilin Xiao5Kai Yang6Taolei Sun7School of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, ChinaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaSchool of Public Health, Hengyang Medical School, University of South China, Hengyang 421001, ChinaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaSchool of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, ChinaParkinson’s disease (PD), a prevalent neurodegenerative disorder characterized by dopaminergic neuron degeneration and α-synuclein accumulation, has been increasingly associated with coagulation dysfunction. This review synthesizes emerging evidence linking dysregulated coagulation to PD pathophysiology. We examine the alterations in coagulation parameters, including elevated fibrinogen levels, impaired fibrinolysis, and platelet dysfunction, which collectively contribute to a hypercoagulable state in PD patients. Epidemiological studies have revealed a higher incidence of thrombotic events, such as deep vein thrombosis (DVT) and stroke, among PD patients, suggesting significant comorbidity between PD and coagulation disorders. This review explores the potential pathophysiological mechanisms underlying this association, focusing on the roles of inflammation and oxidative stress. Additionally, we discuss the limitations of current research and propose future directions. This comprehensive analysis underscores the importance of understanding the coagulation–neurodegeneration axis in PD, which may lead to novel diagnostic and therapeutic strategies for this debilitating condition.https://www.mdpi.com/2073-4409/13/22/1874coagulation disorderParkinson’s diseaseplateletfibrinolysisdeep veinthrombosis |
| spellingShingle | Xinqing Wang Wenxin Li Xinyue Zhao Ning Hu Xi Wang Xilin Xiao Kai Yang Taolei Sun Dysregulated Coagulation in Parkinson’s Disease Cells coagulation disorder Parkinson’s disease platelet fibrinolysis deep vein thrombosis |
| title | Dysregulated Coagulation in Parkinson’s Disease |
| title_full | Dysregulated Coagulation in Parkinson’s Disease |
| title_fullStr | Dysregulated Coagulation in Parkinson’s Disease |
| title_full_unstemmed | Dysregulated Coagulation in Parkinson’s Disease |
| title_short | Dysregulated Coagulation in Parkinson’s Disease |
| title_sort | dysregulated coagulation in parkinson s disease |
| topic | coagulation disorder Parkinson’s disease platelet fibrinolysis deep vein thrombosis |
| url | https://www.mdpi.com/2073-4409/13/22/1874 |
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