GATA2 participates in protection against hypoxia-induced pulmonary vascular remodeling.

GATA2 participates in protection against hypoxia-induced pulmonary vascular remodeling.

The vascular endothelium is vital for cardio-pulmonary homeostasis and, thus, plays a crucial role in preventing life-threatening lung diseases. The transcription factor GATA2 is essential for hematopoiesis and maintaining vascular integrity. Heterozygous mutations in GATA2 can lead to a primary imm...

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Bibliographic Details
Main Authors: Yuko Shirota, Shin'ya Ohmori, James Douglas Engel, Takashi Moriguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0315446
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