Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists

Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists

Transient receptor potential vanilloid (TRPV) 4 is involved in signaling pathways specifically mediating pain and inflammation, making it a promising target for the treatment of various painful and inflammatory conditions. However, only one drug candidate targeting TRPV4 has entered the clinical tri...

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Bibliographic Details
Main Authors: Atefeh Saadabadi, Linda Wilkman, Marja Rantanen, Ari-Pekka Koivisto, Outi M. H. Salo-Ahen
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
TRPV4 antagonists
molecular docking
MD simulation
pharmacophore modeling
FLIPR assay
Online Access:https://www.mdpi.com/1420-3049/30/1/100
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