Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma
Abstract Aim We previously reported that abdominal aortic calcification is associated with poor overall and recurrence‐free survival after hepatectomy for hepatocellular carcinoma (HCC). However, the effect of abdominal aortic calcification on cancer‐specific prognosis in very old patients with seve...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Annals of Gastroenterological Surgery |
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| Online Access: | https://doi.org/10.1002/ags3.12838 |
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| author | Yosuke Namba Masahiro Ohira Yuki Imaoka Michinori Hamaoka Masakazu Hashimoto Takashi Onoe Daisuke Takei Koichi Oishi Megumi Yamaguchi Tomoyuki Abe Takeshi Tadokoro Sotaro Fukuhara Ko Oshita Keiso Matsubara Naruhiko Honmyo Shintaro Kuroda Hiroyuki Tahara Tsuyoshi Kobayashi Kentaro Ide Hideki Ohdan |
| author_facet | Yosuke Namba Masahiro Ohira Yuki Imaoka Michinori Hamaoka Masakazu Hashimoto Takashi Onoe Daisuke Takei Koichi Oishi Megumi Yamaguchi Tomoyuki Abe Takeshi Tadokoro Sotaro Fukuhara Ko Oshita Keiso Matsubara Naruhiko Honmyo Shintaro Kuroda Hiroyuki Tahara Tsuyoshi Kobayashi Kentaro Ide Hideki Ohdan |
| author_sort | Yosuke Namba |
| collection | DOAJ |
| description | Abstract Aim We previously reported that abdominal aortic calcification is associated with poor overall and recurrence‐free survival after hepatectomy for hepatocellular carcinoma (HCC). However, the effect of abdominal aortic calcification on cancer‐specific prognosis in very old patients with several comorbidities remains unknown. This multicenter study aimed to evaluate the impact of abdominal aortic calcification on the cumulative recurrence rate and recurrence‐free survival in patients with HCC aged >80 years. Methods We retrospectively analyzed the data of 128 patients (aged ≥80 years) who underwent liver resection for hepatocellular carcinoma at seven hospitals belonging to Hiroshima Surgical Study Group of Clinical Oncology between January 2014 and December 2018. Patients were divided into two groups: high and low abdominal aortic calcification groups. The primary endpoints were cumulative recurrence rate and recurrence‐free survival. Results Kaplan–Meier survival curve analysis demonstrated that the cumulative recurrence rate in the high abdominal aortic calcification group was significantly higher than that in the low abdominal aortic calcification group, and the high abdominal aortic calcification group had a significantly lower recurrence‐free survival rate. In the multivariate analysis, high abdominal aortic calcification (p = 0.03), high des‐gamma‐carboxyprothrombin score (p = 0.04), and multiple tumors (p < 0.01) were independent predictive factors for recurrent HCC, and high abdominal aortic calcification (p = 0.01) and high des‐gamma‐carboxyprothrombin (p = 0.01) were independent predictive factors for poor cancer‐specific survival. Conclusions Our results indicate that the abdominal aortic calcification score is associated with cumulative recurrence rate and recurrence‐free survival in very old patients with HCC. |
| format | Article |
| id | doaj-art-61e5d60074c34659adeecc4081eae39d |
| institution | Kabale University |
| issn | 2475-0328 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Gastroenterological Surgery |
| spelling | doaj-art-61e5d60074c34659adeecc4081eae39d2025-01-02T04:49:00ZengWileyAnnals of Gastroenterological Surgery2475-03282025-01-019116917710.1002/ags3.12838Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinomaYosuke Namba0Masahiro Ohira1Yuki Imaoka2Michinori Hamaoka3Masakazu Hashimoto4Takashi Onoe5Daisuke Takei6Koichi Oishi7Megumi Yamaguchi8Tomoyuki Abe9Takeshi Tadokoro10Sotaro Fukuhara11Ko Oshita12Keiso Matsubara13Naruhiko Honmyo14Shintaro Kuroda15Hiroyuki Tahara16Tsuyoshi Kobayashi17Kentaro Ide18Hideki Ohdan19Department of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological‐Breast and Transplant Surgery Hiroshima Prefectural Hospital Hiroshima JapanDepartment of Gastroenterological‐Breast and Transplant Surgery Hiroshima Prefectural Hospital Hiroshima JapanDepartment of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center Hiroshima JapanDepartment of Surgery and Endoscopic Surgery JA Onomichi General Hospital Hiroshima JapanDepartment of Surgery Chugoku Rosai Hospital Hiroshima JapanDepartment of Surgery, Hiroshima City North Medical Center Asa Citizens Hospital Hiroshima JapanDepartment of Surgery and Gastroenterological Surgery East Hiroshima Medical Hospital Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanDepartment of Gastroenterological and Transplant Surgery Applied Life Sciences, Institute of Biomedical and Health Sciences Hiroshima University Hiroshima JapanAbstract Aim We previously reported that abdominal aortic calcification is associated with poor overall and recurrence‐free survival after hepatectomy for hepatocellular carcinoma (HCC). However, the effect of abdominal aortic calcification on cancer‐specific prognosis in very old patients with several comorbidities remains unknown. This multicenter study aimed to evaluate the impact of abdominal aortic calcification on the cumulative recurrence rate and recurrence‐free survival in patients with HCC aged >80 years. Methods We retrospectively analyzed the data of 128 patients (aged ≥80 years) who underwent liver resection for hepatocellular carcinoma at seven hospitals belonging to Hiroshima Surgical Study Group of Clinical Oncology between January 2014 and December 2018. Patients were divided into two groups: high and low abdominal aortic calcification groups. The primary endpoints were cumulative recurrence rate and recurrence‐free survival. Results Kaplan–Meier survival curve analysis demonstrated that the cumulative recurrence rate in the high abdominal aortic calcification group was significantly higher than that in the low abdominal aortic calcification group, and the high abdominal aortic calcification group had a significantly lower recurrence‐free survival rate. In the multivariate analysis, high abdominal aortic calcification (p = 0.03), high des‐gamma‐carboxyprothrombin score (p = 0.04), and multiple tumors (p < 0.01) were independent predictive factors for recurrent HCC, and high abdominal aortic calcification (p = 0.01) and high des‐gamma‐carboxyprothrombin (p = 0.01) were independent predictive factors for poor cancer‐specific survival. Conclusions Our results indicate that the abdominal aortic calcification score is associated with cumulative recurrence rate and recurrence‐free survival in very old patients with HCC.https://doi.org/10.1002/ags3.12838abdominal aortic calcificationhepatocellular carcinomasprognosissurvival analysisvery old patients |
| spellingShingle | Yosuke Namba Masahiro Ohira Yuki Imaoka Michinori Hamaoka Masakazu Hashimoto Takashi Onoe Daisuke Takei Koichi Oishi Megumi Yamaguchi Tomoyuki Abe Takeshi Tadokoro Sotaro Fukuhara Ko Oshita Keiso Matsubara Naruhiko Honmyo Shintaro Kuroda Hiroyuki Tahara Tsuyoshi Kobayashi Kentaro Ide Hideki Ohdan Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma Annals of Gastroenterological Surgery abdominal aortic calcification hepatocellular carcinomas prognosis survival analysis very old patients |
| title | Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma |
| title_full | Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma |
| title_fullStr | Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma |
| title_full_unstemmed | Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma |
| title_short | Effect of abdominal aortic calcification on long‐term outcomes after the first liver resection in very old patients with hepatocellular carcinoma |
| title_sort | effect of abdominal aortic calcification on long term outcomes after the first liver resection in very old patients with hepatocellular carcinoma |
| topic | abdominal aortic calcification hepatocellular carcinomas prognosis survival analysis very old patients |
| url | https://doi.org/10.1002/ags3.12838 |
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