Circular RNA NINL accelerates the malignant progression of cervical cancer
Abstract Objective The study’s aim was to explore a novel miRNA/mRNA network mediated by circNINL in cervical cancer (CC). Methods Tumor tissue specimens and normal tissue specimens of 86 CC patients were collected. CircNINL, miR-2467-3p, and specificity protein 1 (SP1) expression levels in tissues...
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| Format: | Article |
| Language: | English |
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Springer
2024-12-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-024-01588-8 |
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| _version_ | 1846112414246895616 |
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| author | ChengCheng Cao HaiFeng Zhang Ting Zhang CuiCui Nie |
| author_facet | ChengCheng Cao HaiFeng Zhang Ting Zhang CuiCui Nie |
| author_sort | ChengCheng Cao |
| collection | DOAJ |
| description | Abstract Objective The study’s aim was to explore a novel miRNA/mRNA network mediated by circNINL in cervical cancer (CC). Methods Tumor tissue specimens and normal tissue specimens of 86 CC patients were collected. CircNINL, miR-2467-3p, and specificity protein 1 (SP1) expression levels in tissues were detected. In Hela cells, transfection was implemented to determine whether CircNINL, miR-2467-3p and SP1 regulated cellular progression. The interaction between circNINL, miR-2467-3p, and SP1 was explored. Results CircNINL and SP1 were abnormally increased whereas miR-2467-3p expression was suppressed in CC. Functionally, circNINL silencing or miR-2467-3p overexpression reduced CC cell progression, whereas circNINL overexpression did the opposite. CircNINL had a spongy effect on miR-2467-3p to regulate SP1 levels. miR-2467-3p inhibition or SP1 overexpression offset the inhibitory effect of circNINL silence on CC malignant progression. Conclusion CircNINL silencing can increase miR-2467-3p, thereby inducing the downregulation of SP1, thereby suppressing CC progression. |
| format | Article |
| id | doaj-art-61e4a8754f144a7fa863442aa97cdc41 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-61e4a8754f144a7fa863442aa97cdc412024-12-22T12:35:42ZengSpringerDiscover Oncology2730-60112024-12-0115111310.1007/s12672-024-01588-8Circular RNA NINL accelerates the malignant progression of cervical cancerChengCheng Cao0HaiFeng Zhang1Ting Zhang2CuiCui Nie3Department of Gynecology, Affiliated Hospital of Shandong Second Medical UniversityDepartment of Gynecology, Affiliated Hospital of Shandong Second Medical UniversityDepartment of Gynecology and Obstetrics, Sunshine Union HospitalDepartment of Gynecology and Obstetrics, Sunshine Union HospitalAbstract Objective The study’s aim was to explore a novel miRNA/mRNA network mediated by circNINL in cervical cancer (CC). Methods Tumor tissue specimens and normal tissue specimens of 86 CC patients were collected. CircNINL, miR-2467-3p, and specificity protein 1 (SP1) expression levels in tissues were detected. In Hela cells, transfection was implemented to determine whether CircNINL, miR-2467-3p and SP1 regulated cellular progression. The interaction between circNINL, miR-2467-3p, and SP1 was explored. Results CircNINL and SP1 were abnormally increased whereas miR-2467-3p expression was suppressed in CC. Functionally, circNINL silencing or miR-2467-3p overexpression reduced CC cell progression, whereas circNINL overexpression did the opposite. CircNINL had a spongy effect on miR-2467-3p to regulate SP1 levels. miR-2467-3p inhibition or SP1 overexpression offset the inhibitory effect of circNINL silence on CC malignant progression. Conclusion CircNINL silencing can increase miR-2467-3p, thereby inducing the downregulation of SP1, thereby suppressing CC progression.https://doi.org/10.1007/s12672-024-01588-8Cervical cancerCircNINLmiR-2467-3pSpecificity protein 1 |
| spellingShingle | ChengCheng Cao HaiFeng Zhang Ting Zhang CuiCui Nie Circular RNA NINL accelerates the malignant progression of cervical cancer Discover Oncology Cervical cancer CircNINL miR-2467-3p Specificity protein 1 |
| title | Circular RNA NINL accelerates the malignant progression of cervical cancer |
| title_full | Circular RNA NINL accelerates the malignant progression of cervical cancer |
| title_fullStr | Circular RNA NINL accelerates the malignant progression of cervical cancer |
| title_full_unstemmed | Circular RNA NINL accelerates the malignant progression of cervical cancer |
| title_short | Circular RNA NINL accelerates the malignant progression of cervical cancer |
| title_sort | circular rna ninl accelerates the malignant progression of cervical cancer |
| topic | Cervical cancer CircNINL miR-2467-3p Specificity protein 1 |
| url | https://doi.org/10.1007/s12672-024-01588-8 |
| work_keys_str_mv | AT chengchengcao circularrnaninlacceleratesthemalignantprogressionofcervicalcancer AT haifengzhang circularrnaninlacceleratesthemalignantprogressionofcervicalcancer AT tingzhang circularrnaninlacceleratesthemalignantprogressionofcervicalcancer AT cuicuinie circularrnaninlacceleratesthemalignantprogressionofcervicalcancer |