Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II study
ObjectivesPreventing malnutrition during chemoradiation (CRT) for head and neck cancer is critical maximizing quality of life (QOL). We sought to assess patient-reported QOL outcomes after integrating exclusive liquid meal replacement with Soylent, a novel meal replacement agent, in patients with he...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1433503/full |
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| author | Luca F. Valle Fang-I Chu Xiaoyan Wang Andrew Erman Jackie Hernandez Elizabeth Kaoh Nicolas Edgar Ann C. Raldow Deborah J. Wong Michael L. Steinberg Amar U. Kishan Robert K. Chin John V. Hegde |
| author_facet | Luca F. Valle Fang-I Chu Xiaoyan Wang Andrew Erman Jackie Hernandez Elizabeth Kaoh Nicolas Edgar Ann C. Raldow Deborah J. Wong Michael L. Steinberg Amar U. Kishan Robert K. Chin John V. Hegde |
| author_sort | Luca F. Valle |
| collection | DOAJ |
| description | ObjectivesPreventing malnutrition during chemoradiation (CRT) for head and neck cancer is critical maximizing quality of life (QOL). We sought to assess patient-reported QOL outcomes after integrating exclusive liquid meal replacement with Soylent, a novel meal replacement agent, in patients with head and neck cancer undergoing CRT.MethodsPatients undergoing definitive or adjuvant concurrent CRT for locally advanced head and neck cancer enrolled on our single-institution, prospective phase II protocol evaluating nutritional replacement with Soylent. Patients who reached 5% body weight loss during CRT were transitioned to Soylent meal replacement for all nutritional needs. Patients who reached 10% body weight loss were recommended for gastrostomy tube (G-tube) placement. UW-QOL and FACT-H&N questionnaires assessed patient-reported QOL prior to the receipt of CRT and following conclusion of CRT. Paired t-test or Wilcoxon signed-rank test were performed to assess for differences between scores at each follow-up time point and baseline.ResultsOf the 60 enrolled patients, 51/60 (85%) lost 5% of their pre-treatment body weight. Among these patients, 48/51 (94%) were successfully transitioned to Soylent. 22/48 patients subsequently lost 10% of their pre-treatment body weight, and 3/22 (14%) underwent G-tube placement with the remainder declining. This resulted in an overall G-tube rate of 5%. Among the 41 patients evaluable for QOL data, the nadirs for overall and health-related UW-QOL were reached at 1 month and rebounded to exceed baseline by 6 months. FACT-H&N survey scores were reduced from 32 at baseline to 20 at 1 month (adjusted p<0.001) and 26 at 3 months (adjusted p<0.001), but increased to 29, 30, and 27 at 6, 12, and 18 months, without significant differences as compared to baseline (adjusted p>0.38 for all).ConclusionsWe report high patient adherence and a 5% G-tube placement rate with exclusive meal replacement with Soylent in patients undergoing concurrent CRT for head and neck cancers. |
| format | Article |
| id | doaj-art-61ca88ecfc3f47918a7a5c0ebf5d6bb8 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-61ca88ecfc3f47918a7a5c0ebf5d6bb82025-01-07T06:47:04ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14335031433503Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II studyLuca F. Valle0Fang-I Chu1Xiaoyan Wang2Andrew Erman3Jackie Hernandez4Elizabeth Kaoh5Nicolas Edgar6Ann C. Raldow7Deborah J. Wong8Michael L. Steinberg9Amar U. Kishan10Robert K. Chin11John V. Hegde12Department of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Medicine Statistical Core, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Speech Pathology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDavid Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Medicine, Division of Hematology Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesDepartment of Radiation Oncology, University of California, Los Angeles, Los Angeles, CA, United StatesObjectivesPreventing malnutrition during chemoradiation (CRT) for head and neck cancer is critical maximizing quality of life (QOL). We sought to assess patient-reported QOL outcomes after integrating exclusive liquid meal replacement with Soylent, a novel meal replacement agent, in patients with head and neck cancer undergoing CRT.MethodsPatients undergoing definitive or adjuvant concurrent CRT for locally advanced head and neck cancer enrolled on our single-institution, prospective phase II protocol evaluating nutritional replacement with Soylent. Patients who reached 5% body weight loss during CRT were transitioned to Soylent meal replacement for all nutritional needs. Patients who reached 10% body weight loss were recommended for gastrostomy tube (G-tube) placement. UW-QOL and FACT-H&N questionnaires assessed patient-reported QOL prior to the receipt of CRT and following conclusion of CRT. Paired t-test or Wilcoxon signed-rank test were performed to assess for differences between scores at each follow-up time point and baseline.ResultsOf the 60 enrolled patients, 51/60 (85%) lost 5% of their pre-treatment body weight. Among these patients, 48/51 (94%) were successfully transitioned to Soylent. 22/48 patients subsequently lost 10% of their pre-treatment body weight, and 3/22 (14%) underwent G-tube placement with the remainder declining. This resulted in an overall G-tube rate of 5%. Among the 41 patients evaluable for QOL data, the nadirs for overall and health-related UW-QOL were reached at 1 month and rebounded to exceed baseline by 6 months. FACT-H&N survey scores were reduced from 32 at baseline to 20 at 1 month (adjusted p<0.001) and 26 at 3 months (adjusted p<0.001), but increased to 29, 30, and 27 at 6, 12, and 18 months, without significant differences as compared to baseline (adjusted p>0.38 for all).ConclusionsWe report high patient adherence and a 5% G-tube placement rate with exclusive meal replacement with Soylent in patients undergoing concurrent CRT for head and neck cancers.https://www.frontiersin.org/articles/10.3389/fonc.2024.1433503/fullhead and neck cancerchemoradiationnutritiongastrostomy tubequality of life |
| spellingShingle | Luca F. Valle Fang-I Chu Xiaoyan Wang Andrew Erman Jackie Hernandez Elizabeth Kaoh Nicolas Edgar Ann C. Raldow Deborah J. Wong Michael L. Steinberg Amar U. Kishan Robert K. Chin John V. Hegde Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II study Frontiers in Oncology head and neck cancer chemoradiation nutrition gastrostomy tube quality of life |
| title | Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II study |
| title_full | Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II study |
| title_fullStr | Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II study |
| title_full_unstemmed | Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II study |
| title_short | Patient-reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation: results from a phase II study |
| title_sort | patient reported quality of life and adherence outcomes after integrating exclusive liquid meal replacement in patients with head and neck cancer undergoing chemoradiation results from a phase ii study |
| topic | head and neck cancer chemoradiation nutrition gastrostomy tube quality of life |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1433503/full |
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