Conjunctival melanoma with pronounced central corneal invasion: One-year relapse free follow-up
Purpose: Conjunctival melanoma with large corneal involvement is a rarity. We here present a case of conjunctival melanoma with pronounced central corneal involvement. Observation: A 69-year-old fair white male presented with a visual axis impeding corneal nodular lesion with associated conjunctival...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | American Journal of Ophthalmology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993624001725 |
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| author | Colya N. Englisch Tim Berger Fidelis Flockerzi Max Bofferding Berthold Seitz |
| author_facet | Colya N. Englisch Tim Berger Fidelis Flockerzi Max Bofferding Berthold Seitz |
| author_sort | Colya N. Englisch |
| collection | DOAJ |
| description | Purpose: Conjunctival melanoma with large corneal involvement is a rarity. We here present a case of conjunctival melanoma with pronounced central corneal involvement. Observation: A 69-year-old fair white male presented with a visual axis impeding corneal nodular lesion with associated conjunctival melanosis. Tumor excision with intraoperative mitomycin c (0.02 %) application for 180 seconds and amniotic membrane transplantation for defect coverage was performed in retrobulbar anesthesia. Histopathological evaluation revealed the nodular lesion to be a conjunctival melanoma (pT1a) with associated conjunctival melanocytic intraepithelial lesion (C-MIL). Conclusion and importance: Most conjunctival melanomas with corneal affection reach a radial corneal involvement of 1 mm. The here reported case accounted for 4 mm, which is seldom and therefore an important report. Surgical excision followed by intraoperative and postoperative mitomycin c exposure was a successful primary treatment. Currently there are no signs of tumor relapse in any part of the eye or the organism 12 months after excision. However, the long-term follow-up needs to be awaited. |
| format | Article |
| id | doaj-art-61b544e6712e4cd68ca7572e2ecc2913 |
| institution | Kabale University |
| issn | 2451-9936 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj-art-61b544e6712e4cd68ca7572e2ecc29132024-12-18T08:50:37ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362024-12-0136102162Conjunctival melanoma with pronounced central corneal invasion: One-year relapse free follow-upColya N. Englisch0Tim Berger1Fidelis Flockerzi2Max Bofferding3Berthold Seitz4Department of Ophthalmology, Saarland University, 66421 Homburg, Saar, Germany; Department of Experimental Ophthalmology, Saarland University, 66421 Homburg, Saar, GermanyDepartment of Ophthalmology, Saarland University, 66421 Homburg, Saar, Germany; Corresponding author. Department of Ophthalmology, Saarland University, Kirrberger Str., D-66421 Homburg, Saar, Germany.Institute of Pathology, Saarland University, 66421 Homburg, Saar, GermanyDepartment of Ophthalmology, Saarland University, 66421 Homburg, Saar, GermanyDepartment of Ophthalmology, Saarland University, 66421 Homburg, Saar, GermanyPurpose: Conjunctival melanoma with large corneal involvement is a rarity. We here present a case of conjunctival melanoma with pronounced central corneal involvement. Observation: A 69-year-old fair white male presented with a visual axis impeding corneal nodular lesion with associated conjunctival melanosis. Tumor excision with intraoperative mitomycin c (0.02 %) application for 180 seconds and amniotic membrane transplantation for defect coverage was performed in retrobulbar anesthesia. Histopathological evaluation revealed the nodular lesion to be a conjunctival melanoma (pT1a) with associated conjunctival melanocytic intraepithelial lesion (C-MIL). Conclusion and importance: Most conjunctival melanomas with corneal affection reach a radial corneal involvement of 1 mm. The here reported case accounted for 4 mm, which is seldom and therefore an important report. Surgical excision followed by intraoperative and postoperative mitomycin c exposure was a successful primary treatment. Currently there are no signs of tumor relapse in any part of the eye or the organism 12 months after excision. However, the long-term follow-up needs to be awaited.http://www.sciencedirect.com/science/article/pii/S2451993624001725Conjunctival melanomaConjunctival melanocytic intraepithelial lesionPrimary acquired melanosisCorneal involvementSurgical removalMitomycin c |
| spellingShingle | Colya N. Englisch Tim Berger Fidelis Flockerzi Max Bofferding Berthold Seitz Conjunctival melanoma with pronounced central corneal invasion: One-year relapse free follow-up American Journal of Ophthalmology Case Reports Conjunctival melanoma Conjunctival melanocytic intraepithelial lesion Primary acquired melanosis Corneal involvement Surgical removal Mitomycin c |
| title | Conjunctival melanoma with pronounced central corneal invasion: One-year relapse free follow-up |
| title_full | Conjunctival melanoma with pronounced central corneal invasion: One-year relapse free follow-up |
| title_fullStr | Conjunctival melanoma with pronounced central corneal invasion: One-year relapse free follow-up |
| title_full_unstemmed | Conjunctival melanoma with pronounced central corneal invasion: One-year relapse free follow-up |
| title_short | Conjunctival melanoma with pronounced central corneal invasion: One-year relapse free follow-up |
| title_sort | conjunctival melanoma with pronounced central corneal invasion one year relapse free follow up |
| topic | Conjunctival melanoma Conjunctival melanocytic intraepithelial lesion Primary acquired melanosis Corneal involvement Surgical removal Mitomycin c |
| url | http://www.sciencedirect.com/science/article/pii/S2451993624001725 |
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