Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice?
Oesophageal and gastric cancer outcomes remain poor despite the introduction of new treatments in the past decade. Most patients subjected to chemotherapy or surgery do not, in the long term, benefit from treatment but suffer side-effects. Although next-generation sequencing has accelerated the iden...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | ESMO Gastrointestinal Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949819824000529 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846119327483297792 |
|---|---|
| author | V. Kunene M. Ding M. Yap E.A. Griffiths P. Taniere D. Fackrell S. Butler G. Contino |
| author_facet | V. Kunene M. Ding M. Yap E.A. Griffiths P. Taniere D. Fackrell S. Butler G. Contino |
| author_sort | V. Kunene |
| collection | DOAJ |
| description | Oesophageal and gastric cancer outcomes remain poor despite the introduction of new treatments in the past decade. Most patients subjected to chemotherapy or surgery do not, in the long term, benefit from treatment but suffer side-effects. Although next-generation sequencing has accelerated the identification of various genomic aberrations, most have yet to be applied to routine clinical practice. Here, we review published data from systemic reviews and meta-analyses from the past 8 years reporting prognostic markers and why these have not gained traction in clinical practice and how we can improve on this. |
| format | Article |
| id | doaj-art-61a47cb7afca48bca9a0b20ce7e8dd0d |
| institution | Kabale University |
| issn | 2949-8198 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | ESMO Gastrointestinal Oncology |
| spelling | doaj-art-61a47cb7afca48bca9a0b20ce7e8dd0d2024-12-17T05:02:27ZengElsevierESMO Gastrointestinal Oncology2949-81982024-12-016100091Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice?V. Kunene0M. Ding1M. Yap2E.A. Griffiths3P. Taniere4D. Fackrell5S. Butler6G. Contino7Queen Elizabeth Hospital Birmingham, University Hospitals of Birmingham NHS Foundation Trust, Birmingham; Correspondence to: Dr Victoria Kunene, Cancer Centre, Queen Elizabeth Hospital, Mindelsohn Way, Birmingham, B15 2TH, UK. Tel: +44-121-371-1303Queen Elizabeth Hospital Birmingham, University Hospitals of Birmingham NHS Foundation Trust, Birmingham; Institute of Cancer and Genomic Sciences, University of Birmingham, BirminghamInstitute of Cancer and Genomic Sciences, University of Birmingham, BirminghamQueen Elizabeth Hospital Birmingham, University Hospitals of Birmingham NHS Foundation Trust, Birmingham; Institute of Cancer and Genomic Sciences, University of Birmingham, BirminghamQueen Elizabeth Hospital Birmingham, University Hospitals of Birmingham NHS Foundation Trust, BirminghamQueen Elizabeth Hospital Birmingham, University Hospitals of Birmingham NHS Foundation Trust, BirminghamWest Midland Regional Genetics Laboratory, Birmingham Women’s Hospital, Birmingham, UKInstitute of Cancer and Genomic Sciences, University of Birmingham, BirminghamOesophageal and gastric cancer outcomes remain poor despite the introduction of new treatments in the past decade. Most patients subjected to chemotherapy or surgery do not, in the long term, benefit from treatment but suffer side-effects. Although next-generation sequencing has accelerated the identification of various genomic aberrations, most have yet to be applied to routine clinical practice. Here, we review published data from systemic reviews and meta-analyses from the past 8 years reporting prognostic markers and why these have not gained traction in clinical practice and how we can improve on this.http://www.sciencedirect.com/science/article/pii/S2949819824000529prognostic markersoesophageal cancergastric cancerstomach canceradenocarcinomasquamous cell carcinoma immunohistochemistry |
| spellingShingle | V. Kunene M. Ding M. Yap E.A. Griffiths P. Taniere D. Fackrell S. Butler G. Contino Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice? ESMO Gastrointestinal Oncology prognostic markers oesophageal cancer gastric cancer stomach cancer adenocarcinoma squamous cell carcinoma immunohistochemistry |
| title | Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice? |
| title_full | Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice? |
| title_fullStr | Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice? |
| title_full_unstemmed | Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice? |
| title_short | Prognostic markers in oesophageal and gastric cancer review. Are they ready for clinical practice? |
| title_sort | prognostic markers in oesophageal and gastric cancer review are they ready for clinical practice |
| topic | prognostic markers oesophageal cancer gastric cancer stomach cancer adenocarcinoma squamous cell carcinoma immunohistochemistry |
| url | http://www.sciencedirect.com/science/article/pii/S2949819824000529 |
| work_keys_str_mv | AT vkunene prognosticmarkersinoesophagealandgastriccancerreviewaretheyreadyforclinicalpractice AT mding prognosticmarkersinoesophagealandgastriccancerreviewaretheyreadyforclinicalpractice AT myap prognosticmarkersinoesophagealandgastriccancerreviewaretheyreadyforclinicalpractice AT eagriffiths prognosticmarkersinoesophagealandgastriccancerreviewaretheyreadyforclinicalpractice AT ptaniere prognosticmarkersinoesophagealandgastriccancerreviewaretheyreadyforclinicalpractice AT dfackrell prognosticmarkersinoesophagealandgastriccancerreviewaretheyreadyforclinicalpractice AT sbutler prognosticmarkersinoesophagealandgastriccancerreviewaretheyreadyforclinicalpractice AT gcontino prognosticmarkersinoesophagealandgastriccancerreviewaretheyreadyforclinicalpractice |