Acute tolerance to rocuronium -A case report-
Background A booster dose can result in a similar reaction to the initial dose. Neuromuscular blocking agents (NMBAs) can produce a comparable reaction in the absence of specific pathophysiologic alterations. Case An initial dose of rocuronium 40 mg was given to a male patient (50 years old, height...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Anesthesiologists
2024-10-01
|
| Series: | Anesthesia and Pain Medicine |
| Subjects: | |
| Online Access: | http://anesth-pain-med.org/upload/pdf/apm-24064.pdf |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846164405677457408 |
|---|---|
| author | Jong Ho Kim Sang joon Park Youngsuk Kwon Sung Mi Hwang Hong Seuk Yang |
| author_facet | Jong Ho Kim Sang joon Park Youngsuk Kwon Sung Mi Hwang Hong Seuk Yang |
| author_sort | Jong Ho Kim |
| collection | DOAJ |
| description | Background A booster dose can result in a similar reaction to the initial dose. Neuromuscular blocking agents (NMBAs) can produce a comparable reaction in the absence of specific pathophysiologic alterations. Case An initial dose of rocuronium 40 mg was given to a male patient (50 years old, height 168 cm, weight 54 kg, body mass index 19.13 kg/m2) for anesthesia. The onset was usual, but the duration was brief. Two booster doses were administered at 20 min intervals, but recovery came quickly. So, acute tolerance was suspected. Muscle function was restored to greater than train-of-four ratio 0.75 while spontaneous aided breathing was maintained without the need of further NMBAs. Following the operation, sugammadex (1.85 mg/kg) was provided to prevent residual neuromuscular inhibition. Conclusions Anesthetists must be able to suspect acute tolerance to NMBAs in patients with no unique medical history and have a plan to resolve it. |
| format | Article |
| id | doaj-art-6177193eedc14f9da8e2f2cbe05fec4e |
| institution | Kabale University |
| issn | 1975-5171 2383-7977 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Korean Society of Anesthesiologists |
| record_format | Article |
| series | Anesthesia and Pain Medicine |
| spelling | doaj-art-6177193eedc14f9da8e2f2cbe05fec4e2024-11-18T07:05:31ZengKorean Society of AnesthesiologistsAnesthesia and Pain Medicine1975-51712383-79772024-10-0119433333810.17085/apm.240641276Acute tolerance to rocuronium -A case report-Jong Ho Kim0Sang joon Park1Youngsuk Kwon2Sung Mi Hwang3Hong Seuk Yang4 Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, Korea Department of Anesthesiology and Pain Medicine, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, KoreaBackground A booster dose can result in a similar reaction to the initial dose. Neuromuscular blocking agents (NMBAs) can produce a comparable reaction in the absence of specific pathophysiologic alterations. Case An initial dose of rocuronium 40 mg was given to a male patient (50 years old, height 168 cm, weight 54 kg, body mass index 19.13 kg/m2) for anesthesia. The onset was usual, but the duration was brief. Two booster doses were administered at 20 min intervals, but recovery came quickly. So, acute tolerance was suspected. Muscle function was restored to greater than train-of-four ratio 0.75 while spontaneous aided breathing was maintained without the need of further NMBAs. Following the operation, sugammadex (1.85 mg/kg) was provided to prevent residual neuromuscular inhibition. Conclusions Anesthetists must be able to suspect acute tolerance to NMBAs in patients with no unique medical history and have a plan to resolve it.http://anesth-pain-med.org/upload/pdf/apm-24064.pdfdurationneuromuscular nondepolarizing agentsonset timerocuroniumtolerance |
| spellingShingle | Jong Ho Kim Sang joon Park Youngsuk Kwon Sung Mi Hwang Hong Seuk Yang Acute tolerance to rocuronium -A case report- Anesthesia and Pain Medicine duration neuromuscular nondepolarizing agents onset time rocuronium tolerance |
| title | Acute tolerance to rocuronium -A case report- |
| title_full | Acute tolerance to rocuronium -A case report- |
| title_fullStr | Acute tolerance to rocuronium -A case report- |
| title_full_unstemmed | Acute tolerance to rocuronium -A case report- |
| title_short | Acute tolerance to rocuronium -A case report- |
| title_sort | acute tolerance to rocuronium a case report |
| topic | duration neuromuscular nondepolarizing agents onset time rocuronium tolerance |
| url | http://anesth-pain-med.org/upload/pdf/apm-24064.pdf |
| work_keys_str_mv | AT jonghokim acutetolerancetorocuroniumacasereport AT sangjoonpark acutetolerancetorocuroniumacasereport AT youngsukkwon acutetolerancetorocuroniumacasereport AT sungmihwang acutetolerancetorocuroniumacasereport AT hongseukyang acutetolerancetorocuroniumacasereport |