Safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species (Phytobiotics Futterzusatzstoffe GmbH)

Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of copper lysinate sulfate as nutritional feed additive for all animal species. The additive has not yet been authorised in the EU. The FEEDAP Panel concluded that the...

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Main Authors: EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Roberto Edoardo Villa, Giovanna Azimonti, Eleftherios Bonos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Ronette Gehring, Boet Glandorf, Maryline Kouba, Marta López‐Alonso, Francesca Marcon, Carlo Nebbia, Alena Pechová, Miguel Prieto‐Maradona, Ilen Röhe, Katerina Theodoridou, Georges Bories, Jürgen Gropp, Jaume Galobart, Paola Manini, Fabiola Pizzo, Maria Vittoria Vettori, Anita Radovnikovic, Alberto Navarro‐Villa
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:EFSA Journal
Subjects:
Online Access:https://doi.org/10.2903/j.efsa.2025.9555
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author EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Roberto Edoardo Villa
Giovanna Azimonti
Eleftherios Bonos
Henrik Christensen
Mojca Durjava
Birgit Dusemund
Ronette Gehring
Boet Glandorf
Maryline Kouba
Marta López‐Alonso
Francesca Marcon
Carlo Nebbia
Alena Pechová
Miguel Prieto‐Maradona
Ilen Röhe
Katerina Theodoridou
Georges Bories
Jürgen Gropp
Jaume Galobart
Paola Manini
Fabiola Pizzo
Maria Vittoria Vettori
Anita Radovnikovic
Alberto Navarro‐Villa
author_facet EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Roberto Edoardo Villa
Giovanna Azimonti
Eleftherios Bonos
Henrik Christensen
Mojca Durjava
Birgit Dusemund
Ronette Gehring
Boet Glandorf
Maryline Kouba
Marta López‐Alonso
Francesca Marcon
Carlo Nebbia
Alena Pechová
Miguel Prieto‐Maradona
Ilen Röhe
Katerina Theodoridou
Georges Bories
Jürgen Gropp
Jaume Galobart
Paola Manini
Fabiola Pizzo
Maria Vittoria Vettori
Anita Radovnikovic
Alberto Navarro‐Villa
author_sort EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
collection DOAJ
description Abstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of copper lysinate sulfate as nutritional feed additive for all animal species. The additive has not yet been authorised in the EU. The FEEDAP Panel concluded that the additive copper lysinate sulfate is safe for all animal species and categories at the respective maximum authorised total copper levels in feed. In the absence of reliable deposition data, the FEEDAP Panel could not conclude on the safety of the additive for the consumer. In the absence of data, the FEEDAP Panel could not conclude on the eye irritation potential of the additive. The Panel concluded that the additive is not a skin irritant and thus it should be considered a skin and respiratory sensitiser; inhalation and dermal exposure are considered a risk. The FEEDAP Panel concluded that the use of the additive under the proposed conditions of use is safe for the environment. The Panel was not in the position to conclude on the efficacy of the additive at the maximum authorised inclusion level.
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spelling doaj-art-6166030bbd8a485392b51c574d5f6a3e2025-08-20T03:58:36ZengWileyEFSA Journal1831-47322025-07-01237n/an/a10.2903/j.efsa.2025.9555Safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species (Phytobiotics Futterzusatzstoffe GmbH)EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)Roberto Edoardo VillaGiovanna AzimontiEleftherios BonosHenrik ChristensenMojca DurjavaBirgit DusemundRonette GehringBoet GlandorfMaryline KoubaMarta López‐AlonsoFrancesca MarconCarlo NebbiaAlena PechováMiguel Prieto‐MaradonaIlen RöheKaterina TheodoridouGeorges BoriesJürgen GroppJaume GalobartPaola ManiniFabiola PizzoMaria Vittoria VettoriAnita RadovnikovicAlberto Navarro‐VillaAbstract Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of copper lysinate sulfate as nutritional feed additive for all animal species. The additive has not yet been authorised in the EU. The FEEDAP Panel concluded that the additive copper lysinate sulfate is safe for all animal species and categories at the respective maximum authorised total copper levels in feed. In the absence of reliable deposition data, the FEEDAP Panel could not conclude on the safety of the additive for the consumer. In the absence of data, the FEEDAP Panel could not conclude on the eye irritation potential of the additive. The Panel concluded that the additive is not a skin irritant and thus it should be considered a skin and respiratory sensitiser; inhalation and dermal exposure are considered a risk. The FEEDAP Panel concluded that the use of the additive under the proposed conditions of use is safe for the environment. The Panel was not in the position to conclude on the efficacy of the additive at the maximum authorised inclusion level.https://doi.org/10.2903/j.efsa.2025.9555coppercopper lysinate sulfateefficacynutritional additivePlexomin L‐Cusafety
spellingShingle EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Roberto Edoardo Villa
Giovanna Azimonti
Eleftherios Bonos
Henrik Christensen
Mojca Durjava
Birgit Dusemund
Ronette Gehring
Boet Glandorf
Maryline Kouba
Marta López‐Alonso
Francesca Marcon
Carlo Nebbia
Alena Pechová
Miguel Prieto‐Maradona
Ilen Röhe
Katerina Theodoridou
Georges Bories
Jürgen Gropp
Jaume Galobart
Paola Manini
Fabiola Pizzo
Maria Vittoria Vettori
Anita Radovnikovic
Alberto Navarro‐Villa
Safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species (Phytobiotics Futterzusatzstoffe GmbH)
EFSA Journal
copper
copper lysinate sulfate
efficacy
nutritional additive
Plexomin L‐Cu
safety
title Safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species (Phytobiotics Futterzusatzstoffe GmbH)
title_full Safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species (Phytobiotics Futterzusatzstoffe GmbH)
title_fullStr Safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species (Phytobiotics Futterzusatzstoffe GmbH)
title_full_unstemmed Safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species (Phytobiotics Futterzusatzstoffe GmbH)
title_short Safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species (Phytobiotics Futterzusatzstoffe GmbH)
title_sort safety and efficacy of a feed additive consisting of copper lysinate sulfate for all animal species phytobiotics futterzusatzstoffe gmbh
topic copper
copper lysinate sulfate
efficacy
nutritional additive
Plexomin L‐Cu
safety
url https://doi.org/10.2903/j.efsa.2025.9555
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