Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report
Abstract Background Ketamine treatment presents a novel approach for addressing refractory conditions, such as major depressive disorder, suicidal ideation, and posttraumatic stress disorder, which often co-occur and pose significant challenges for clinicians. This study explores the clinical and el...
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| Format: | Article |
| Language: | English |
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BMC
2024-12-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-024-04972-8 |
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| author | S. Asad K. Latifzai V. T. Eliopoulos D. S. Oakley J. Pates G. Towers |
| author_facet | S. Asad K. Latifzai V. T. Eliopoulos D. S. Oakley J. Pates G. Towers |
| author_sort | S. Asad |
| collection | DOAJ |
| description | Abstract Background Ketamine treatment presents a novel approach for addressing refractory conditions, such as major depressive disorder, suicidal ideation, and posttraumatic stress disorder, which often co-occur and pose significant challenges for clinicians. This study explores the clinical and electrophysiological outcomes of ketamine treatment in two cases, shedding light on its potential efficacy and mechanisms of action. Case presentation The first case involves a 56-year-old Caucasian male with chronic posttraumatic stress disorder and suicidal ideation, and the second case involves a 52-year-old Caucasian female with treatment-resistant major depressive disorder. Both patients opted for ketamine treatment after years of unsuccessful interventions. The male patient received nine ketamine infusions over 18 months, while the female patient received five infusions over one month. Symptom improvement was accompanied by distinct electrophysiological changes, as observed through electroencephalogram and evoked electroencephalogram responses. These changes persisted for several months post-treatment, offering hope for individuals grappling with challenging chronic conditions. Conclusion Ketamine infusions resulted in significant and sustained symptomatic improvement in both cases, accompanied by distinct electrophysiological changes indicative of altered brain function. These findings highlight the potential of ketamine as an alternative treatment for refractory conditions, such as major depressive disorder and posttraumatic stress disorder, offering relief and functional recovery for certain patients. Further research is warranted to elucidate the underlying mechanisms and optimize treatment protocols. |
| format | Article |
| id | doaj-art-61606cbf583e49a2865389d79b2d44cc |
| institution | Kabale University |
| issn | 1752-1947 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj-art-61606cbf583e49a2865389d79b2d44cc2024-12-29T12:32:51ZengBMCJournal of Medical Case Reports1752-19472024-12-011811710.1186/s13256-024-04972-8Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case reportS. Asad0K. Latifzai1V. T. Eliopoulos2D. S. Oakley3J. Pates4G. Towers5Baptist Medical CenterRocky Mountain Regenerative MedicineRocky Mountain Regenerative MedicineWAVi ResearchBaseline NeuroWAVi ResearchAbstract Background Ketamine treatment presents a novel approach for addressing refractory conditions, such as major depressive disorder, suicidal ideation, and posttraumatic stress disorder, which often co-occur and pose significant challenges for clinicians. This study explores the clinical and electrophysiological outcomes of ketamine treatment in two cases, shedding light on its potential efficacy and mechanisms of action. Case presentation The first case involves a 56-year-old Caucasian male with chronic posttraumatic stress disorder and suicidal ideation, and the second case involves a 52-year-old Caucasian female with treatment-resistant major depressive disorder. Both patients opted for ketamine treatment after years of unsuccessful interventions. The male patient received nine ketamine infusions over 18 months, while the female patient received five infusions over one month. Symptom improvement was accompanied by distinct electrophysiological changes, as observed through electroencephalogram and evoked electroencephalogram responses. These changes persisted for several months post-treatment, offering hope for individuals grappling with challenging chronic conditions. Conclusion Ketamine infusions resulted in significant and sustained symptomatic improvement in both cases, accompanied by distinct electrophysiological changes indicative of altered brain function. These findings highlight the potential of ketamine as an alternative treatment for refractory conditions, such as major depressive disorder and posttraumatic stress disorder, offering relief and functional recovery for certain patients. Further research is warranted to elucidate the underlying mechanisms and optimize treatment protocols.https://doi.org/10.1186/s13256-024-04972-8KetamineMajor depressive disorderPTSDElectroencephalogramCase report |
| spellingShingle | S. Asad K. Latifzai V. T. Eliopoulos D. S. Oakley J. Pates G. Towers Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report Journal of Medical Case Reports Ketamine Major depressive disorder PTSD Electroencephalogram Case report |
| title | Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report |
| title_full | Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report |
| title_fullStr | Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report |
| title_full_unstemmed | Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report |
| title_short | Depression, post-traumatic stress disorder, suicidal ideation and ketamine: a case report |
| title_sort | depression post traumatic stress disorder suicidal ideation and ketamine a case report |
| topic | Ketamine Major depressive disorder PTSD Electroencephalogram Case report |
| url | https://doi.org/10.1186/s13256-024-04972-8 |
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