Evaluation of the neuroprotective potential of benzylidene digoxin 15 against oxidative stress in a neuroinflammation models induced by lipopolysaccharide and on neuronal differentiation of hippocampal neural precursor cells

Evaluation of the neuroprotective potential of benzylidene digoxin 15 against oxidative stress in a neuroinflammation models induced by lipopolysaccharide and on neuronal differentiation of hippocampal neural precursor cells

Neuroinflammation, often driven by the overproduction of reactive oxygen species (ROS), plays a crucial role in the pathogenesis of neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. The susceptibility of the brain to oxidative stress is attributed to its high metabolic activit...

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Main Authors: Gilvânia A. Cordeiro, Jessica A. Faria, Leticia Pavan, Israel J. P. Garcia, Eduarda P. F. I. Neves, Gustavo Fernando de Frazao Lima, Hericles M. Campos, Pâmela Y. Ferreira, Paulo C. Ghedini, Elisa M. Kawamoto, Maira C. Lima, José A. F. P. Villar, Ana Maria M. Orellana, Leandro A. Barbosa, Cristoforo Scavone, Jacqueline A. Leite, Hérica L. Santos
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
BD-15
neuroinflammation
cerebellum
prefrontal cortex
oxidative stress
hippocampal neurogenesis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1537720/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1537720/full

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