Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization

Cannabidiol Alleviates Chronic Prostatitis and Chronic Pelvic Pain Syndrome via CB2 Receptor Activation and TRPV1 Desensitization

Purpose: This study elucidates the mechanism of the physiological effect of cannabidiol (CBD) by assessing its impact on lipopolysaccharide (LPS)-induced inflammation in RWPE-1 cells and prostatitis-induced by 17β-estradiol and dihydrotestosterone in a rat model, focusing on its therapeutic potent...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jun Jie Piao, Soomin Kim, Dongho Shin, Hwa Jong Lee, Kyung-Hwa Jeon, Wen Jie Tian, Kyung Jae Hur, Jong Soo Kang, Hyun-Je Park, Joo Young Cha, Aeri Song, Sang-Hyuck Park, Mahadevan Rajasekaran, Woong Jin Bae, Sungjoo Kim Yoon, Sae Woong Kim
Format:	Article
Language:	English
Published:	Korean Society for Sexual Medicine and Andrology 2025-01-01
Series:	The World Journal of Men's Health
Subjects:	cannabidiol prostatitis receptor; cannabinoid; cb2 toll-like receptor 4 trpv1 receptor
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Hormone Receptors in Cervicovaginal Cells
by: Şayeste Demirezen, et al.
Published: (2013-04-01)

Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation
by: Iona Davies, et al.
Published: (2025-02-01)

Synergetic role of TRPV4 inhibitor and mechanical loading on reducing inflammation
by: Parto Babaniamansour, et al.
Published: (2025-01-01)

Multi-center, prospective, non-interventional, observational study on the efficacy and safety of Mirabek® in adult patients with overactive bladder
by: Jee Soo Park, et al.
Published: (2025-01-01)

GPCRs in hypothalamic neurons and their roles in controlling food intake and metabolism
by: Tian Qiu, et al.
Published: (2025-02-01)

Comparison of tissue-based and plasma-based testing for mutation in non–small cell lung cancer patients
by: Yoon Kyung Kang, et al.
Published: (2025-01-01)

Spinal Involvement of TRPV1 and PI3K/AKT/mTOR Pathway During Chronic Postoperative Pain in Mice
by: Gabriela Xavier Santos, et al.
Published: (2025-01-01)

The role of TASK-1 and TRPV1 channels in the male reproductive system
by: Dawon Kang, et al.
Published: (2024-12-01)

System-Wide Expression and Function of Olfactory Receptors in Mammals
by: S. June Oh
Published: (2018-03-01)

Single or multiple treatments with lusutrombopag in subjects with thrombocytopenia and chronic liver disease needing an invasive procedure
by: Davide Scalabrini, et al.
Published: (2023-08-01)

Editorial: Community series in BCR signaling and B cell activation, volume 2
by: Wenxia Song, et al.
Published: (2025-01-01)

Receptor Status Differences in Prognosis for Breast Cancer
by: Yelda Deligöz Bildacı, et al.
Published: (2024-07-01)

Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins
by: Andrew Z. Ma, et al.
Published: (2025-02-01)

Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases
by: Eun Ji Lee, et al.
Published: (2013-12-01)

Optimization and calibration of 384-well kinetic Ca2+ mobilization assays for the human transient receptor potential cation channels TRPM8, TRPV1, and TRPA1
by: David A. Close, et al.
Published: (2025-01-01)

Cytokine soluble receptors in perinatal and early neonatal life
by: Efthimia Protonotariou, et al.
Published: (2003-01-01)

Treatment of irritable bowel syndrome: the past, present and future
by: V. T. Ivashkin, et al.
Published: (2015-03-01)

To study the expression of estrogen, progesterone receptor and p53 immunohistochemistry markers in subtyping endometrial carcinoma
by: Anuja Yadav, et al.
Published: (2023-07-01)

Night-break treatment with blue and green lights regulates erect thallus formation in the brown alga Petalonia fascia (KU-1293)
by: Yuya Maegawa, et al.
Published: (2025-01-01)

Worse survival of hepatocellular cancer patients with membranous insulin receptor overexpression
by: Steffen Markus Heckl, et al.
Published: (2025-01-01)

Genome-scale evolution in local populations of wild chimpanzees
by: Takashi Hayakawa, et al.
Published: (2025-01-01)

The relationship between histamine receptor type 4 gene polymorphism (rs11662595) and response to H1 antihistamine drugs in patients with chronic idiopathic urticaria
by: Ebrahim Mohammadi, et al.
Published: (2024-10-01)

A prognostic model of 8-T/B cell receptor-related signatures for hepatocellular carcinoma
by: Xuan Zuo, et al.
Published: (2025-01-01)

ANALYSIS OF THE INTERACTION OF LIPID METABOLISM ALLELES IN DYSLIPIDEMIA
by: I. V. Nikolaev, et al.
Published: (2015-01-01)

Phytocompounds from Indonesia Medicinal Herbs as Potential Apelin Receptor Agonist for Heart Failure Therapy: An In-silico Approach
by: Muhamad Rizqy Fadhillah, et al.
Published: (2025-01-01)

Attraction and aversion of noctuid moths to fermented food sources coordinated by olfactory receptors from distinct gene families
by: Xiao-Qing Hou, et al.
Published: (2025-01-01)

Taltirelin induces TH expression by regulating TRHR and RARα in medium spiny neurons
by: Kedong Zhu, et al.
Published: (2024-12-01)

Conserved pattern-based classification of human odorant receptor multigene family
by: Sang Eun Ryu, et al.
Published: (2024-11-01)

The glucocorticoid hypothesis of depression: history and perspectives
by: G. T. Shishkina, et al.
Published: (2016-05-01)

AXL inhibition in treatment-resistant metastatic adenoid cystic carcinoma
by: Sivakamavalli Jeyachandran
Published: (2024-06-01)

Structure- and Ligand-Based Virtual Screening for Identification of Novel TRPV4 Antagonists
by: Atefeh Saadabadi, et al.
Published: (2024-12-01)

TRPV4 modulates inflammatory responses and apoptosis in enteric glial cells triggered by Clostridioides difficile toxins A and B
by: Dvison de Melo Pacífico, et al.
Published: (2025-01-01)

Neuroprotection by chronic administration of Fluoroethylnormemantine (FENM) in mouse models of Alzheimer's disease
by: Allison Carles, et al.
Published: (2025-01-01)

Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy
by: Qin Si, et al.
Published: (2025-01-01)

Appendicitis After Initiation of Tirzepatide
by: Chan G, et al.
Published: (2025-01-01)

Effect of neonatal dexamethasone treatment on cognitive abilities of adult male mice and gene expression in the hypothalamus
by: N. P. Bondar, et al.
Published: (2019-07-01)

Phages adapt to recognize an O-antigen polysaccharide site by mutating the “backup” tail protein ORF59, enabling reinfection of phage-resistant Klebsiella pneumoniae
by: Ping Li, et al.
Published: (2025-12-01)

Interactions of the anti-FcRn monoclonal antibody, rozanolixizumab, with Fcγ receptors and functional impact on immune cells in vitro
by: Omar S. Qureshi, et al.
Published: (2024-12-01)

Rationale and Design of a Randomized, Open‐Label, Parallel‐Group Study of Esaxerenone Versus Angiotensin Receptor Blockers in Older Patients With Uncontrolled Hypertension on Calcium Channel Blocker Monotherapy (ESCORT‐HT)
by: Kazuomi Kario, et al.
Published: (2025-01-01)

The relationship between mutation carriage of BRCA1/2 and clinicopathological characteristics in women with breast cancer – experience from a diagnostic centre in Turkey
by: Neslihan Duzkale, et al.
Published: (2024-09-01)