Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation
Peanut allergy is majorly related to severe food induced allergic reactions. Several food including cow’s milk, hen’s eggs, soy, wheat, peanuts, tree nuts (walnuts, hazelnuts, almonds, cashews, pecans and pistachios), f ish and shellf ish are responsible for more than 90% of food allergies. Here, we...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tsinghua University Press
2024-05-01
|
| Series: | Food Science and Human Wellness |
| Subjects: | |
| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250111 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550186946494464 |
|---|---|
| author | Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee |
| author_facet | Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee |
| author_sort | Emmanuel Kemmler |
| collection | DOAJ |
| description | Peanut allergy is majorly related to severe food induced allergic reactions. Several food including cow’s milk, hen’s eggs, soy, wheat, peanuts, tree nuts (walnuts, hazelnuts, almonds, cashews, pecans and pistachios), f ish and shellf ish are responsible for more than 90% of food allergies. Here, we provide promising insights using a large-scale data-driven analysis, comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts, tree nuts (walnuts, almonds, cashews, pecans and pistachios) and soybean.Additionally, we have analysed the chemical compositions of peanuts in different processed form raw, boiled and dry-roasted. Using the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors (PPARs) and its isoform and their interaction with dietary lipids may have signif icant effect on allergic response. The results obtained from this study will direct future experimental and clinical studies to understand the role of dietary lipids and PPAR-isoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity. |
| format | Article |
| id | doaj-art-61021203135c4d719025c4bc93acb7e1 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-61021203135c4d719025c4bc93acb7e12025-01-10T06:54:23ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-05-011331322133510.26599/FSHW.2022.9250111Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretationEmmanuel Kemmler0Julian Braun1Florent Fauchère2Sabine Dölle-Bierke3Kirsten Beyer4Robert Preissner5Margitta Worm6Priyanka Banerjee7Institute for Physiology, Charité – University Medicine Berlin, Berlin 10115, GermanyMember of the KFO339, FOOD@, Berlin 10115, GermanyMember of the KFO339, FOOD@, Berlin 10115, GermanyMember of the KFO339, FOOD@, Berlin 10115, GermanyMember of the KFO339, FOOD@, Berlin 10115, GermanyInstitute for Physiology, Charité – University Medicine Berlin, Berlin 10115, GermanyMember of the KFO339, FOOD@, Berlin 10115, GermanyInstitute for Physiology, Charité – University Medicine Berlin, Berlin 10115, GermanyPeanut allergy is majorly related to severe food induced allergic reactions. Several food including cow’s milk, hen’s eggs, soy, wheat, peanuts, tree nuts (walnuts, hazelnuts, almonds, cashews, pecans and pistachios), f ish and shellf ish are responsible for more than 90% of food allergies. Here, we provide promising insights using a large-scale data-driven analysis, comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts, tree nuts (walnuts, almonds, cashews, pecans and pistachios) and soybean.Additionally, we have analysed the chemical compositions of peanuts in different processed form raw, boiled and dry-roasted. Using the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors (PPARs) and its isoform and their interaction with dietary lipids may have signif icant effect on allergic response. The results obtained from this study will direct future experimental and clinical studies to understand the role of dietary lipids and PPAR-isoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.https://www.sciopen.com/article/10.26599/FSHW.2022.9250111allergy informaticsknowledge-graphdata analysisfood allergyperoxisome proliferator-activated receptorsfatty acids |
| spellingShingle | Emmanuel Kemmler Julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer Robert Preissner Margitta Worm Priyanka Banerjee Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation Food Science and Human Wellness allergy informatics knowledge-graph data analysis food allergy peroxisome proliferator-activated receptors fatty acids |
| title | Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation |
| title_full | Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation |
| title_fullStr | Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation |
| title_full_unstemmed | Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation |
| title_short | Data-driven analysis of chemicals, proteins and pathways associated with peanut allergy: from molecular networking to biological interpretation |
| title_sort | data driven analysis of chemicals proteins and pathways associated with peanut allergy from molecular networking to biological interpretation |
| topic | allergy informatics knowledge-graph data analysis food allergy peroxisome proliferator-activated receptors fatty acids |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250111 |
| work_keys_str_mv | AT emmanuelkemmler datadrivenanalysisofchemicalsproteinsandpathwaysassociatedwithpeanutallergyfrommolecularnetworkingtobiologicalinterpretation AT julianbraun datadrivenanalysisofchemicalsproteinsandpathwaysassociatedwithpeanutallergyfrommolecularnetworkingtobiologicalinterpretation AT florentfauchere datadrivenanalysisofchemicalsproteinsandpathwaysassociatedwithpeanutallergyfrommolecularnetworkingtobiologicalinterpretation AT sabinedollebierke datadrivenanalysisofchemicalsproteinsandpathwaysassociatedwithpeanutallergyfrommolecularnetworkingtobiologicalinterpretation AT kirstenbeyer datadrivenanalysisofchemicalsproteinsandpathwaysassociatedwithpeanutallergyfrommolecularnetworkingtobiologicalinterpretation AT robertpreissner datadrivenanalysisofchemicalsproteinsandpathwaysassociatedwithpeanutallergyfrommolecularnetworkingtobiologicalinterpretation AT margittaworm datadrivenanalysisofchemicalsproteinsandpathwaysassociatedwithpeanutallergyfrommolecularnetworkingtobiologicalinterpretation AT priyankabanerjee datadrivenanalysisofchemicalsproteinsandpathwaysassociatedwithpeanutallergyfrommolecularnetworkingtobiologicalinterpretation |