shRNA-interfered of Nrf2 reveals a critical role for Keap1-Nrf2 signaling pathway during effects of zearalenone induced oxidative stress in IPEC-J2 cells

shRNA-interfered of Nrf2 reveals a critical role for Keap1-Nrf2 signaling pathway during effects of zearalenone induced oxidative stress in IPEC-J2 cells

Objective This study aims to verify the protective effect of the Kelch-like ECH-associated protein1 (Keap1)–nuclear factor erythroid 2–related factor 2 (Nrf2) signaling pathways by studying the effect of plasmids containing Nrf2–small hairpin RNA (shRNA) interference down-regulation of Nrf2 on zeara...

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Bibliographic Details
Main Authors: Qun Cheng, Shu Zhen Jiang, Li Bo Huang, Wei Ren Yang
Format: Article
Language:English
Published: Asian-Australasian Association of Animal Production Societies 2025-02-01
Series:Animal Bioscience
Subjects:
ipec-j2
keap1-nrf2 signaling pathway
nrf2-shrna
oxidative stress
zearalenone
Online Access:http://www.animbiosci.org/upload/pdf/ab-24-0368.pdf
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