Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL

Systems biology-enabled targeting of NF-κΒ and BCL2 overcomes microenvironment-mediated BH3-mimetic resistance in DLBCL

Abstract In Diffuse Large B-cell Lymphoma (DLBCL), elevated anti-apoptotic BCL2-family proteins (e.g., MCL1, BCL2, BCLXL) and NF-κB subunits (RelA, RelB, cRel) confer poor prognosis. Heterogeneous expression, regulatory complexity, and redundancy offsetting the inhibition of individual proteins, com...

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Main Authors: Aimilia Vareli, Haripriya Vaidehi Narayanan, Heather Clark, Eleanor Jayawant, Hui Zhou, Yi Liu, Emma Kennedy, Lauren Stott, Fabio Simoes, Alexander Hoffmann, Andrea Pepper, Chris Pepper, Simon Mitchell
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07942-0
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