Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment
Yilin Li,1,* Qiwei Yang,1,* Danni Li,2 Wenya Li,1 Wanfu Men1 1Department of Thoracic Surgery, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China; 2Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 11000...
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Dove Medical Press
2025-01-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/exosomes-key-messengers-mediating-the-interaction-between-tumor-cells--peer-reviewed-fulltext-article-IJN |
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| author | Li Y Yang Q Li D Li W Men W |
| author_facet | Li Y Yang Q Li D Li W Men W |
| author_sort | Li Y |
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| description | Yilin Li,1,* Qiwei Yang,1,* Danni Li,2 Wenya Li,1 Wanfu Men1 1Department of Thoracic Surgery, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China; 2Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wanfu Men; Wenya Li, Email 472581624@163.com; saint5288@hotmail.comAbstract: In recent years, with an increasingly profound comprehension of the tumor microenvironment, it has been discovered that the constituent cells within the immune microenvironment, such as macrophages, CD4+T cells, and CD8+T cells, interact with tumor cells in manners conducive to tumorigenesis and progression. Exosomes play a pivotal role as essential mediators for intercellular material exchange and signal transmission in this context. Tumor cell-derived exosomes carrying cargo such as PD-L1 and ncRNAs engage with CD8+T cells to induce cytotoxic responses and facilitate immune evasion, thereby promoting tumor advancement. When combined with current immune checkpoint inhibitors like anti-PD-L1/PD-1 therapy, enhancing CD8+T cell function through exosomal pathways while monitoring and augmenting therapeutic effects can significantly improve efficacy. This review delineates the crucial role of exosomes derived from both tumor cells and CD8+T cells within the tumor microenvironment along with their impact mechanisms on both tumor cells and CD8+T cells. Furthermore, it summarizes the potential for clinical treatment in this realm when integrated with existing immunotherapy methods—particularly exploring the feasibility of clinical translation alongside engineering materials science techniques.Keywords: CD8+T, TME, exosome, EVs |
| format | Article |
| id | doaj-art-60a696c08934494389bdb821715ab4b3 |
| institution | Kabale University |
| issn | 1178-2013 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj-art-60a696c08934494389bdb821715ab4b32025-01-16T16:17:12ZengDove Medical PressInternational Journal of Nanomedicine1178-20132025-01-01Volume 2065366799286Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor MicroenvironmentLi YYang QLi DLi WMen WYilin Li,1,* Qiwei Yang,1,* Danni Li,2 Wenya Li,1 Wanfu Men1 1Department of Thoracic Surgery, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China; 2Department of Medical Oncology, the First Hospital of China Medical University, Shenyang, 110002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wanfu Men; Wenya Li, Email 472581624@163.com; saint5288@hotmail.comAbstract: In recent years, with an increasingly profound comprehension of the tumor microenvironment, it has been discovered that the constituent cells within the immune microenvironment, such as macrophages, CD4+T cells, and CD8+T cells, interact with tumor cells in manners conducive to tumorigenesis and progression. Exosomes play a pivotal role as essential mediators for intercellular material exchange and signal transmission in this context. Tumor cell-derived exosomes carrying cargo such as PD-L1 and ncRNAs engage with CD8+T cells to induce cytotoxic responses and facilitate immune evasion, thereby promoting tumor advancement. When combined with current immune checkpoint inhibitors like anti-PD-L1/PD-1 therapy, enhancing CD8+T cell function through exosomal pathways while monitoring and augmenting therapeutic effects can significantly improve efficacy. This review delineates the crucial role of exosomes derived from both tumor cells and CD8+T cells within the tumor microenvironment along with their impact mechanisms on both tumor cells and CD8+T cells. Furthermore, it summarizes the potential for clinical treatment in this realm when integrated with existing immunotherapy methods—particularly exploring the feasibility of clinical translation alongside engineering materials science techniques.Keywords: CD8+T, TME, exosome, EVshttps://www.dovepress.com/exosomes-key-messengers-mediating-the-interaction-between-tumor-cells--peer-reviewed-fulltext-article-IJNcd8+t，tme，exosome，evs |
| spellingShingle | Li Y Yang Q Li D Li W Men W Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment International Journal of Nanomedicine cd8+t，tme，exosome，evs |
| title | Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment |
| title_full | Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment |
| title_fullStr | Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment |
| title_full_unstemmed | Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment |
| title_short | Exosomes: Key Messengers Mediating the Interaction Between Tumor Cells and CD8+ T Cells in the Tumor Microenvironment |
| title_sort | exosomes key messengers mediating the interaction between tumor cells and cd8 t cells in the tumor microenvironment |
| topic | cd8+t，tme，exosome，evs |
| url | https://www.dovepress.com/exosomes-key-messengers-mediating-the-interaction-between-tumor-cells--peer-reviewed-fulltext-article-IJN |
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