Determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysis
Abstract The production of fine particles by green technology like supercritical carbon dioxide requires the assessment of substantial solubility data at high pressures. This study represents the first determination of the solubility of methyldopa in carbon dioxide at pressures and temperatures rang...
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Nature Portfolio
2025-01-01
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| author | Adil Farooq Wali Sathvik Belagodu Sridhar Sirajunisa Talath Jayachithra Ramakrishna Pillai Javedh Shareef Mullaicharam Bhupathyraaj B. K. Manjunatha Goud Umme Hani |
| author_facet | Adil Farooq Wali Sathvik Belagodu Sridhar Sirajunisa Talath Jayachithra Ramakrishna Pillai Javedh Shareef Mullaicharam Bhupathyraaj B. K. Manjunatha Goud Umme Hani |
| author_sort | Adil Farooq Wali |
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| description | Abstract The production of fine particles by green technology like supercritical carbon dioxide requires the assessment of substantial solubility data at high pressures. This study represents the first determination of the solubility of methyldopa in carbon dioxide at pressures and temperatures ranging from 12 to 30 MPa and from 313.2 to 343.2 K, respectively. The mole fractions were obtained under the aforementioned conditions and ranged from 0.805 × 10⁻5 to 11.345 × 10⁻5. Four empirical models (Chrastil, Bartle et al., Mendez-Santiago, & Teja, and Kumar-Johnston) and two equations of state (Peng-Robinson and Soave-Redlich-Kwong) were used to correlate drug solubility. The K-J model demonstrated the highest accuracy, with an AARD of 8.38% and a R2 value of 0.988. Furthermore, the enthalpy values for the drug in SC-CO₂ were estimated using the Chrastil and Bartle models, resulting in values of 34.35 and 56.87 kJ·mol⁻¹, respectively. The results demonstrate that the SRK more pronounced results than the PR model, with an AARD% of 23.03 and a R2 value of 0.903 compared to 26.42 and 0.837. The article’s conclusions provide a valuable reference for the application of green method in the production of fine particles of methyldopa. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-609a66a9e6064b828c65b2c7992feba72025-01-12T12:21:17ZengNature PortfolioScientific Reports2045-23222025-01-0115111310.1038/s41598-024-84263-wDetermination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysisAdil Farooq Wali0Sathvik Belagodu Sridhar1Sirajunisa Talath2Jayachithra Ramakrishna Pillai3Javedh Shareef4Mullaicharam Bhupathyraaj5B. K. Manjunatha Goud6Umme Hani7Department of Pharmaceutical Chemistry, RAK College of Pharmacy, RAK Medical and Health Sciences UniversityDepartment of Clinical Pharmacy and Pharmacology, RAK College of Pharmacy, RAK Medical and Health Sciences UniversityDepartment of Pharmaceutical Chemistry, RAK College of Pharmacy, RAK Medical and Health Sciences UniversityDepartment of Pharmaceutical Chemistry, RAK College of Pharmacy, RAK Medical and Health Sciences UniversityDepartment of Clinical Pharmacy and Pharmacology, RAK College of Pharmacy, RAK Medical and Health Sciences UniversityCollege of Pharmacy, National University of Science and TechnologyRAK College of Medical Sciences, RAK Medical and Health Sciences University Department of Pharmaceutics, College of Pharmacy, King Khalid UniversityAbstract The production of fine particles by green technology like supercritical carbon dioxide requires the assessment of substantial solubility data at high pressures. This study represents the first determination of the solubility of methyldopa in carbon dioxide at pressures and temperatures ranging from 12 to 30 MPa and from 313.2 to 343.2 K, respectively. The mole fractions were obtained under the aforementioned conditions and ranged from 0.805 × 10⁻5 to 11.345 × 10⁻5. Four empirical models (Chrastil, Bartle et al., Mendez-Santiago, & Teja, and Kumar-Johnston) and two equations of state (Peng-Robinson and Soave-Redlich-Kwong) were used to correlate drug solubility. The K-J model demonstrated the highest accuracy, with an AARD of 8.38% and a R2 value of 0.988. Furthermore, the enthalpy values for the drug in SC-CO₂ were estimated using the Chrastil and Bartle models, resulting in values of 34.35 and 56.87 kJ·mol⁻¹, respectively. The results demonstrate that the SRK more pronounced results than the PR model, with an AARD% of 23.03 and a R2 value of 0.903 compared to 26.42 and 0.837. The article’s conclusions provide a valuable reference for the application of green method in the production of fine particles of methyldopa.https://doi.org/10.1038/s41598-024-84263-wSupercritical fluidSolubilityThermodynamic modelingSemi-empirical and enthalpy |
| spellingShingle | Adil Farooq Wali Sathvik Belagodu Sridhar Sirajunisa Talath Jayachithra Ramakrishna Pillai Javedh Shareef Mullaicharam Bhupathyraaj B. K. Manjunatha Goud Umme Hani Determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysis Scientific Reports Supercritical fluid Solubility Thermodynamic modeling Semi-empirical and enthalpy |
| title | Determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysis |
| title_full | Determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysis |
| title_fullStr | Determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysis |
| title_full_unstemmed | Determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysis |
| title_short | Determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications: thermal analysis |
| title_sort | determination of the solubility of methyldopa in supercritical carbon dioxide for drug delivery applications thermal analysis |
| topic | Supercritical fluid Solubility Thermodynamic modeling Semi-empirical and enthalpy |
| url | https://doi.org/10.1038/s41598-024-84263-w |
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