Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms
Abstract Polymicrobial biofilms adhere to surfaces and enhance pathogen resistance to conventional treatments, significantly contributing to chronic infections in the respiratory tract, oral cavity, chronic wounds, and on medical devices. This review examines antimicrobial peptides (AMPs) as a promi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202410893 |
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| author | Cesar Augusto Roque‐Borda Laura Maria Duran Gleriani Primo Kaila Petronila Medina‐Alarcón Isabella C. Campos Camila de Fátima Nascimento Mauro M. S. Saraiva Angelo Berchieri Junior Ana Marisa Fusco‐Almeida Maria José Soares Mendes‐Giannini João Perdigão Fernando Rogério Pavan Fernando Albericio |
| author_facet | Cesar Augusto Roque‐Borda Laura Maria Duran Gleriani Primo Kaila Petronila Medina‐Alarcón Isabella C. Campos Camila de Fátima Nascimento Mauro M. S. Saraiva Angelo Berchieri Junior Ana Marisa Fusco‐Almeida Maria José Soares Mendes‐Giannini João Perdigão Fernando Rogério Pavan Fernando Albericio |
| author_sort | Cesar Augusto Roque‐Borda |
| collection | DOAJ |
| description | Abstract Polymicrobial biofilms adhere to surfaces and enhance pathogen resistance to conventional treatments, significantly contributing to chronic infections in the respiratory tract, oral cavity, chronic wounds, and on medical devices. This review examines antimicrobial peptides (AMPs) as a promising alternative to traditional antibiotics for treating biofilm‐associated infections. AMPs, which can be produced as part of the innate immune response or synthesized therapeutically, have broad‐spectrum antimicrobial activity, often disrupting microbial cell membranes and causing cell death. Many specifically target negatively charged bacterial membranes, unlike host cell membranes. Research shows AMPs effectively inhibit and disrupt polymicrobial biofilms and can enhance conventional antibiotics' efficacy. Preclinical and clinical research is advancing, with animal studies and clinical trials showing promise against multidrug‐resistant bacteria and fungi. Numerous patents indicate increasing interest in AMPs. However, challenges such as peptide stability, potential cytotoxicity, and high production costs must be addressed. Ongoing research focuses on optimizing AMP structures, enhancing stability, and developing cost‐effective production methods. In summary, AMPs offer a novel approach to combating biofilm‐associated infections, with their unique mechanisms and synergistic potential with existing antibiotics positioning them as promising candidates for future treatments. |
| format | Article |
| id | doaj-art-6096a7eeff2e4bf299313ca0762d77ea |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-6096a7eeff2e4bf299313ca0762d77ea2025-01-09T11:44:45ZengWileyAdvanced Science2198-38442025-01-01121n/an/a10.1002/advs.202410893Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial BiofilmsCesar Augusto Roque‐Borda0Laura Maria Duran Gleriani Primo1Kaila Petronila Medina‐Alarcón2Isabella C. Campos3Camila de Fátima Nascimento4Mauro M. S. Saraiva5Angelo Berchieri Junior6Ana Marisa Fusco‐Almeida7Maria José Soares Mendes‐Giannini8João Perdigão9Fernando Rogério Pavan10Fernando Albericio11Department of Biological Sciences School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP) Araraquara Sao Paulo 14800‐903 BrazilDepartment of Biological Sciences School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP) Araraquara Sao Paulo 14800‐903 BrazilDepartment of Clinical Analysis School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP) Araraquara Sao Paulo 14800‐903 BrazilSão Paulo State University (UNESP) School of Agricultural and Veterinarian Sciences Jaboticabal Sao Paulo 14884‐900 BrazilSão Paulo State University (UNESP) School of Agricultural and Veterinarian Sciences Jaboticabal Sao Paulo 14884‐900 BrazilSão Paulo State University (UNESP) School of Agricultural and Veterinarian Sciences Jaboticabal Sao Paulo 14884‐900 BrazilSão Paulo State University (UNESP) School of Agricultural and Veterinarian Sciences Jaboticabal Sao Paulo 14884‐900 BrazilDepartment of Clinical Analysis School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP) Araraquara Sao Paulo 14800‐903 BrazilDepartment of Clinical Analysis School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP) Araraquara Sao Paulo 14800‐903 BraziliMed.ULisboa–Institute for Medicines Research Faculty of Pharmacy University of Lisbon Lisbon 1649004 PortugalDepartment of Biological Sciences School of Pharmaceutical Sciences Universidade Estadual Paulista (UNESP) Araraquara Sao Paulo 14800‐903 BrazilPeptide Science Laboratory School of Chemistry and Physics University of KwaZulu‐Natal Durban 4001 South AfricaAbstract Polymicrobial biofilms adhere to surfaces and enhance pathogen resistance to conventional treatments, significantly contributing to chronic infections in the respiratory tract, oral cavity, chronic wounds, and on medical devices. This review examines antimicrobial peptides (AMPs) as a promising alternative to traditional antibiotics for treating biofilm‐associated infections. AMPs, which can be produced as part of the innate immune response or synthesized therapeutically, have broad‐spectrum antimicrobial activity, often disrupting microbial cell membranes and causing cell death. Many specifically target negatively charged bacterial membranes, unlike host cell membranes. Research shows AMPs effectively inhibit and disrupt polymicrobial biofilms and can enhance conventional antibiotics' efficacy. Preclinical and clinical research is advancing, with animal studies and clinical trials showing promise against multidrug‐resistant bacteria and fungi. Numerous patents indicate increasing interest in AMPs. However, challenges such as peptide stability, potential cytotoxicity, and high production costs must be addressed. Ongoing research focuses on optimizing AMP structures, enhancing stability, and developing cost‐effective production methods. In summary, AMPs offer a novel approach to combating biofilm‐associated infections, with their unique mechanisms and synergistic potential with existing antibiotics positioning them as promising candidates for future treatments.https://doi.org/10.1002/advs.202410893antimicrobial alternativesbiofilmsdrug discoverypolymicrobial interactions |
| spellingShingle | Cesar Augusto Roque‐Borda Laura Maria Duran Gleriani Primo Kaila Petronila Medina‐Alarcón Isabella C. Campos Camila de Fátima Nascimento Mauro M. S. Saraiva Angelo Berchieri Junior Ana Marisa Fusco‐Almeida Maria José Soares Mendes‐Giannini João Perdigão Fernando Rogério Pavan Fernando Albericio Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms Advanced Science antimicrobial alternatives biofilms drug discovery polymicrobial interactions |
| title | Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms |
| title_full | Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms |
| title_fullStr | Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms |
| title_full_unstemmed | Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms |
| title_short | Antimicrobial Peptides: A Promising Alternative to Conventional Antimicrobials for Combating Polymicrobial Biofilms |
| title_sort | antimicrobial peptides a promising alternative to conventional antimicrobials for combating polymicrobial biofilms |
| topic | antimicrobial alternatives biofilms drug discovery polymicrobial interactions |
| url | https://doi.org/10.1002/advs.202410893 |
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