VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin
Background: von Hippel–Lindau (VHL) tumour suppressor gene inactivation is associated with clear cell renal cell carcinoma (CCRCC) development. The VHL protein (pVHL) has been proposed to regulate the expression of several proteins including Hypoxia Inducible Factor-α (HIF-α), carbonic anhydrase (CA...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.3233/ACP-CLO-2010-0541 |
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| author | Michelle J. Nyhan Shereen M. El Mashad Tracey R. O’Donovan Sarfraz Ahmad Chris Collins Paul Sweeney Eamonn Rogers Gerald C. O’Sullivan Sharon L. McKenna |
| author_facet | Michelle J. Nyhan Shereen M. El Mashad Tracey R. O’Donovan Sarfraz Ahmad Chris Collins Paul Sweeney Eamonn Rogers Gerald C. O’Sullivan Sharon L. McKenna |
| author_sort | Michelle J. Nyhan |
| collection | DOAJ |
| description | Background: von Hippel–Lindau (VHL) tumour suppressor gene inactivation is associated with clear cell renal cell carcinoma (CCRCC) development. The VHL protein (pVHL) has been proposed to regulate the expression of several proteins including Hypoxia Inducible Factor-α (HIF-α), carbonic anhydrase (CA)IX, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 and osteopontin. pVHL has been characterized in vitro, however, clinical studies are limited. We evaluated the impact of VHL genetic alterations on the expression of several pVHL protein targets in paired normal and tumor tissue. |
| format | Article |
| id | doaj-art-608e2d6f834445ecaf4ad0143184a793 |
| institution | Kabale University |
| issn | 2210-7177 2210-7185 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-608e2d6f834445ecaf4ad0143184a7932025-02-03T05:47:26ZengWileyAnalytical Cellular Pathology2210-71772210-71852010-01-01333-412113210.3233/ACP-CLO-2010-0541VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and OsteopontinMichelle J. Nyhan0Shereen M. El Mashad1Tracey R. O’Donovan2Sarfraz Ahmad3Chris Collins4Paul Sweeney5Eamonn Rogers6Gerald C. O’Sullivan7Sharon L. McKenna8Leslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, IrelandLeslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, IrelandLeslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, IrelandLeslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, IrelandLeslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, IrelandDepartment of Surgery, Mercy University Hospital, Cork, IrelandDepartment of Surgery, Mercy University Hospital, Cork, IrelandLeslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, IrelandLeslie C. Quick Laboratory, Cork Cancer Research Centre, BioSciences Institute, University College Cork and Mercy University Hospital, Cork, IrelandBackground: von Hippel–Lindau (VHL) tumour suppressor gene inactivation is associated with clear cell renal cell carcinoma (CCRCC) development. The VHL protein (pVHL) has been proposed to regulate the expression of several proteins including Hypoxia Inducible Factor-α (HIF-α), carbonic anhydrase (CA)IX, heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 and osteopontin. pVHL has been characterized in vitro, however, clinical studies are limited. We evaluated the impact of VHL genetic alterations on the expression of several pVHL protein targets in paired normal and tumor tissue.http://dx.doi.org/10.3233/ACP-CLO-2010-0541 |
| spellingShingle | Michelle J. Nyhan Shereen M. El Mashad Tracey R. O’Donovan Sarfraz Ahmad Chris Collins Paul Sweeney Eamonn Rogers Gerald C. O’Sullivan Sharon L. McKenna VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin Analytical Cellular Pathology |
| title | VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin |
| title_full | VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin |
| title_fullStr | VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin |
| title_full_unstemmed | VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin |
| title_short | VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin |
| title_sort | vhl genetic alteration in ccrcc does not determine de regulation of hif caix hnrnp a2 b1 and osteopontin |
| url | http://dx.doi.org/10.3233/ACP-CLO-2010-0541 |
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