Serum N‐Terminal Pro‐B‐Type Natriuretic Peptide Is Associated With Insulin Resistance in Chinese: Danyang Study
ABSTRACT The association of serum N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) with insulin resistance (IR), as measured by homeostasis model assessment of insulin resistance (HOMA‐IR), in the general population is unclear. Our study aimed to characterize its relationship in a large communi...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14906 |
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| author | Ziwen Zheng Junya Liang Yun Gao Mulian Hua Siqi Zhang Ming Liu Zhuyuan Fang |
| author_facet | Ziwen Zheng Junya Liang Yun Gao Mulian Hua Siqi Zhang Ming Liu Zhuyuan Fang |
| author_sort | Ziwen Zheng |
| collection | DOAJ |
| description | ABSTRACT The association of serum N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) with insulin resistance (IR), as measured by homeostasis model assessment of insulin resistance (HOMA‐IR), in the general population is unclear. Our study aimed to characterize its relationship in a large community‐based population. Subjects were recruited from the Danyang city between 2017 and 2019. Serum NT‐proBNP was measured using an enhanced chemiluminescence immunoassay. IR was defined by a HOMA‐IR in the highest sex‐specific quartile. Categorical and continuous analyses were performed with sex‐specific NT‐proBNP tertiles and naturally logarithmically transformed NT‐proBNP (lnNTproBNP), respectively. The 2945 participants (mean age 52.8 years) included 1728 (58.7%) women, 1167 (39.6%) hypertensive patients, 269 (9.1%) diabetic patients, and 736 (25.0%) patients with IR. In simple and multivariate‐adjusted regression analyses, serum lnNTproBNP were both negatively associated with HOMA‐IR (β = −0.19 to −0.25; p < 0.0001). Similar results were also obtained in multiple subgroup analyses. In multiple logistic regression analyses, elevated serum NT‐proBNP was associated with lower risks of IR (odds ratios: 0.68 and 0.39; 95% confidence intervals: 0.61–0.74 and 0.30–0.50 for lnNTproBNP and top vs. bottom tertiles, respectively; p < 0.0001). In conclusion, increased serum NT‐proBNP level was strongly associated with a lower risk of IR in Chinese. |
| format | Article |
| id | doaj-art-60840d40e64340e5b8e6ebf45d6d2c26 |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-60840d40e64340e5b8e6ebf45d6d2c262025-08-20T03:44:28ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762024-11-0126111256126310.1111/jch.14906Serum N‐Terminal Pro‐B‐Type Natriuretic Peptide Is Associated With Insulin Resistance in Chinese: Danyang StudyZiwen Zheng0Junya Liang1Yun Gao2Mulian Hua3Siqi Zhang4Ming Liu5Zhuyuan Fang6Department of Cardiology Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Nanjing Jiangsu ChinaInstitute of Hypertension Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Nanjing Jiangsu ChinaInstitute of Hypertension Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Nanjing Jiangsu ChinaInstitute of Hypertension Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Nanjing Jiangsu ChinaInstitute of Hypertension Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Nanjing Jiangsu ChinaDepartment of Cardiology Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Nanjing Jiangsu ChinaDepartment of Cardiology Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Nanjing Jiangsu ChinaABSTRACT The association of serum N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) with insulin resistance (IR), as measured by homeostasis model assessment of insulin resistance (HOMA‐IR), in the general population is unclear. Our study aimed to characterize its relationship in a large community‐based population. Subjects were recruited from the Danyang city between 2017 and 2019. Serum NT‐proBNP was measured using an enhanced chemiluminescence immunoassay. IR was defined by a HOMA‐IR in the highest sex‐specific quartile. Categorical and continuous analyses were performed with sex‐specific NT‐proBNP tertiles and naturally logarithmically transformed NT‐proBNP (lnNTproBNP), respectively. The 2945 participants (mean age 52.8 years) included 1728 (58.7%) women, 1167 (39.6%) hypertensive patients, 269 (9.1%) diabetic patients, and 736 (25.0%) patients with IR. In simple and multivariate‐adjusted regression analyses, serum lnNTproBNP were both negatively associated with HOMA‐IR (β = −0.19 to −0.25; p < 0.0001). Similar results were also obtained in multiple subgroup analyses. In multiple logistic regression analyses, elevated serum NT‐proBNP was associated with lower risks of IR (odds ratios: 0.68 and 0.39; 95% confidence intervals: 0.61–0.74 and 0.30–0.50 for lnNTproBNP and top vs. bottom tertiles, respectively; p < 0.0001). In conclusion, increased serum NT‐proBNP level was strongly associated with a lower risk of IR in Chinese.https://doi.org/10.1111/jch.14906homeostasis model assessment of insulin resistanceinsulin resistanceN‐terminal pro‐B‐type natriuretic peptide |
| spellingShingle | Ziwen Zheng Junya Liang Yun Gao Mulian Hua Siqi Zhang Ming Liu Zhuyuan Fang Serum N‐Terminal Pro‐B‐Type Natriuretic Peptide Is Associated With Insulin Resistance in Chinese: Danyang Study The Journal of Clinical Hypertension homeostasis model assessment of insulin resistance insulin resistance N‐terminal pro‐B‐type natriuretic peptide |
| title | Serum N‐Terminal Pro‐B‐Type Natriuretic Peptide Is Associated With Insulin Resistance in Chinese: Danyang Study |
| title_full | Serum N‐Terminal Pro‐B‐Type Natriuretic Peptide Is Associated With Insulin Resistance in Chinese: Danyang Study |
| title_fullStr | Serum N‐Terminal Pro‐B‐Type Natriuretic Peptide Is Associated With Insulin Resistance in Chinese: Danyang Study |
| title_full_unstemmed | Serum N‐Terminal Pro‐B‐Type Natriuretic Peptide Is Associated With Insulin Resistance in Chinese: Danyang Study |
| title_short | Serum N‐Terminal Pro‐B‐Type Natriuretic Peptide Is Associated With Insulin Resistance in Chinese: Danyang Study |
| title_sort | serum n terminal pro b type natriuretic peptide is associated with insulin resistance in chinese danyang study |
| topic | homeostasis model assessment of insulin resistance insulin resistance N‐terminal pro‐B‐type natriuretic peptide |
| url | https://doi.org/10.1111/jch.14906 |
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