The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in China
Background The triglyceride-glucose (TyG) index has emerged as a credible surrogate indicator of insulin resistance in recent years. This study aimed to investigate the relationship between the TyG index and the deterioration of kidney function in patients with cardiovascular-kidney-metabolic (CKM)...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2446656 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841558638147141632 |
|---|---|
| author | Zhi Shang Song-Tao Feng Hui Qian Zhen-Ling Deng Yue Wang Yue-Ming Gao |
| author_facet | Zhi Shang Song-Tao Feng Hui Qian Zhen-Ling Deng Yue Wang Yue-Ming Gao |
| author_sort | Zhi Shang |
| collection | DOAJ |
| description | Background The triglyceride-glucose (TyG) index has emerged as a credible surrogate indicator of insulin resistance in recent years. This study aimed to investigate the relationship between the TyG index and the deterioration of kidney function in patients with cardiovascular-kidney-metabolic (CKM) syndrome.Methods In this retrospective cohort study from China, 27,407 hospitalized patients with stage 1–4 CKM syndrome were consecutively included. The participants were categorized into four groups according to TyG index quartiles. The study outcome was the deterioration of kidney function, defined as a decrease in estimated glomerular filtration rate (eGFR) ≥ 40% from baseline. Restricted cubic spline (RCS) curves and multivariate Cox analysis were used for analysis.Results 3,248 outcome events were recorded during a mean follow-up period of 34 months. The RCS plot displayed a U-shaped curve between the baseline TyG index and the deterioration of kidney function (P for non-linear < 0.001). The baseline TyG index with the lowest hazard ratio (HR) of eGFR decline ranges from 8.65 to 9.15, with an inflection point at 8.88. After fully adjusting for covariates, HRs and 95% confidence intervals (CIs) from the lowest to highest TyG index quartile were 1.00 (reference), 0.82 (0.74, 0.91), 0.78 (0.70, 0.86), and 0.93 (0.83, 1.03), respectively. According to the Kaplan-Meier survival curve, the risk of deterioration of kidney function was elevated in the lowest and highest TyG index quartiles (log-rank test, p < 0.0001).Conclusions In individuals with CKM syndrome, a non-linear U-shaped relationship existed between the baseline TyG index and the deterioration of kidney function. |
| format | Article |
| id | doaj-art-605442c470c84b5fa2be1121a2a634de |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-605442c470c84b5fa2be1121a2a634de2025-01-06T07:14:00ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2024.2446656The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in ChinaZhi Shang0Song-Tao Feng1Hui Qian2Zhen-Ling Deng3Yue Wang4Yue-Ming Gao5Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, ChinaDepartment of Nephrology, Jiangsu University Affiliated People’s Hospital, Jiangsu, ChinaJiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Jiangsu, ChinaDepartment of Nephrology, Peking University Third Hospital, Beijing, ChinaDepartment of Nephrology, Peking University Third Hospital, Beijing, ChinaDepartment of Nephrology, Peking University Third Hospital, Beijing, ChinaBackground The triglyceride-glucose (TyG) index has emerged as a credible surrogate indicator of insulin resistance in recent years. This study aimed to investigate the relationship between the TyG index and the deterioration of kidney function in patients with cardiovascular-kidney-metabolic (CKM) syndrome.Methods In this retrospective cohort study from China, 27,407 hospitalized patients with stage 1–4 CKM syndrome were consecutively included. The participants were categorized into four groups according to TyG index quartiles. The study outcome was the deterioration of kidney function, defined as a decrease in estimated glomerular filtration rate (eGFR) ≥ 40% from baseline. Restricted cubic spline (RCS) curves and multivariate Cox analysis were used for analysis.Results 3,248 outcome events were recorded during a mean follow-up period of 34 months. The RCS plot displayed a U-shaped curve between the baseline TyG index and the deterioration of kidney function (P for non-linear < 0.001). The baseline TyG index with the lowest hazard ratio (HR) of eGFR decline ranges from 8.65 to 9.15, with an inflection point at 8.88. After fully adjusting for covariates, HRs and 95% confidence intervals (CIs) from the lowest to highest TyG index quartile were 1.00 (reference), 0.82 (0.74, 0.91), 0.78 (0.70, 0.86), and 0.93 (0.83, 1.03), respectively. According to the Kaplan-Meier survival curve, the risk of deterioration of kidney function was elevated in the lowest and highest TyG index quartiles (log-rank test, p < 0.0001).Conclusions In individuals with CKM syndrome, a non-linear U-shaped relationship existed between the baseline TyG index and the deterioration of kidney function.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2446656Cardiovascular-kidney-metabolic syndrometriglyceride-glucose indexkidney functioninsulin resistance |
| spellingShingle | Zhi Shang Song-Tao Feng Hui Qian Zhen-Ling Deng Yue Wang Yue-Ming Gao The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in China Renal Failure Cardiovascular-kidney-metabolic syndrome triglyceride-glucose index kidney function insulin resistance |
| title | The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in China |
| title_full | The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in China |
| title_fullStr | The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in China |
| title_full_unstemmed | The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in China |
| title_short | The impact of the triglyceride-glucose index on the deterioration of kidney function in patients with cardiovascular-kidney-metabolic syndrome: insight from a large cohort study in China |
| title_sort | impact of the triglyceride glucose index on the deterioration of kidney function in patients with cardiovascular kidney metabolic syndrome insight from a large cohort study in china |
| topic | Cardiovascular-kidney-metabolic syndrome triglyceride-glucose index kidney function insulin resistance |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2446656 |
| work_keys_str_mv | AT zhishang theimpactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT songtaofeng theimpactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT huiqian theimpactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT zhenlingdeng theimpactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT yuewang theimpactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT yueminggao theimpactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT zhishang impactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT songtaofeng impactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT huiqian impactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT zhenlingdeng impactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT yuewang impactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina AT yueminggao impactofthetriglycerideglucoseindexonthedeteriorationofkidneyfunctioninpatientswithcardiovascularkidneymetabolicsyndromeinsightfromalargecohortstudyinchina |