The homodimerization domain of the Stl repressor is crucial for efficient inhibition of mycobacterial dUTPase

The homodimerization domain of the Stl repressor is crucial for efficient inhibition of mycobacterial dUTPase

Abstract The dUTPase is a key DNA repair enzyme in Mycobacterium tuberculosis, and it may serve as a novel promising anti-tuberculosis target. Stl repressor from Staphylococcus aureus was shown to bind to and inhibit dUTPases from various sources, and its expression in mycobacterial cells interfered...

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Main Authors: Zoé S. Tóth, Ibolya Leveles, Kinga Nyíri, Gergely N. Nagy, Veronika Harmat, Thapakorn Jaroentomeechai, Oliver Ozohanics, Rebecca L. Miller, Marina Ballesteros Álvarez, Beáta G. Vértessy, András Benedek
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-76349-2
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