Effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement: a systematic review and meta-analysis
Abstract Objective To systematically evaluate the impact of pulmonary hypertension (PH) on the prognosis of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). Methods We conducted a meta-analysis of cohort studies to evaluate the impact of PH on the p...
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BMC
2025-07-01
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| Series: | BMC Cardiovascular Disorders |
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| Online Access: | https://doi.org/10.1186/s12872-025-04962-8 |
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| author | Yang Ruan Xin Wei Qun Li Zening Jin |
| author_facet | Yang Ruan Xin Wei Qun Li Zening Jin |
| author_sort | Yang Ruan |
| collection | DOAJ |
| description | Abstract Objective To systematically evaluate the impact of pulmonary hypertension (PH) on the prognosis of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). Methods We conducted a meta-analysis of cohort studies to evaluate the impact of PH on the prognosis of patients with severe AS undergoing TAVR. A comprehensive search was performed in PubMed, Embase, and the Cochrane Library up to June 2024. Data extraction and quality assessment were carried out independently by two researchers. Statistical analyses were conducted using STATA 15.1. Results A total of 7 cohort studies were included. Meta-analysis results demonstrated that patients with PH who underwent TAVR had significantly higher rates of all-cause mortality at 30 days (OR = 2.52, 95% CI: 1.70–3.73, P < 0.001), 1 year (OR = 2.01, 95% CI: 1.52–2.66, P < 0.001) and 1-year cardiovascular mortality (OR = 2.56, 95% CI: 1.84–3.57, P < 0.001), compared to those without PH. There was no statistical difference between the two groups in major bleeding events, stroke, myocardial infarction and pacemaker implantation. Conclusion PH is associated with higher short- and long-term mortality in AS patients undergoing TAVR, suggesting it as a crucial factor in patient prognosis post-procedure. |
| format | Article |
| id | doaj-art-602c20f1e33e48329efd4bfa00611f09 |
| institution | Kabale University |
| issn | 1471-2261 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Cardiovascular Disorders |
| spelling | doaj-art-602c20f1e33e48329efd4bfa00611f092025-08-20T03:42:40ZengBMCBMC Cardiovascular Disorders1471-22612025-07-0125111210.1186/s12872-025-04962-8Effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement: a systematic review and meta-analysisYang Ruan0Xin Wei1Qun Li2Zening Jin3Department of Cardiology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Cardiology, Beijing Tiantan Hospital, Capital Medical UniversityAbstract Objective To systematically evaluate the impact of pulmonary hypertension (PH) on the prognosis of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve replacement (TAVR). Methods We conducted a meta-analysis of cohort studies to evaluate the impact of PH on the prognosis of patients with severe AS undergoing TAVR. A comprehensive search was performed in PubMed, Embase, and the Cochrane Library up to June 2024. Data extraction and quality assessment were carried out independently by two researchers. Statistical analyses were conducted using STATA 15.1. Results A total of 7 cohort studies were included. Meta-analysis results demonstrated that patients with PH who underwent TAVR had significantly higher rates of all-cause mortality at 30 days (OR = 2.52, 95% CI: 1.70–3.73, P < 0.001), 1 year (OR = 2.01, 95% CI: 1.52–2.66, P < 0.001) and 1-year cardiovascular mortality (OR = 2.56, 95% CI: 1.84–3.57, P < 0.001), compared to those without PH. There was no statistical difference between the two groups in major bleeding events, stroke, myocardial infarction and pacemaker implantation. Conclusion PH is associated with higher short- and long-term mortality in AS patients undergoing TAVR, suggesting it as a crucial factor in patient prognosis post-procedure.https://doi.org/10.1186/s12872-025-04962-8Pulmonary hypertensionAortic stenosisTranscatheter aortic valve replacementTAVISystematic review and meta-analysis |
| spellingShingle | Yang Ruan Xin Wei Qun Li Zening Jin Effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement: a systematic review and meta-analysis BMC Cardiovascular Disorders Pulmonary hypertension Aortic stenosis Transcatheter aortic valve replacement TAVI Systematic review and meta-analysis |
| title | Effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement: a systematic review and meta-analysis |
| title_full | Effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement: a systematic review and meta-analysis |
| title_fullStr | Effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement: a systematic review and meta-analysis |
| title_full_unstemmed | Effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement: a systematic review and meta-analysis |
| title_short | Effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement: a systematic review and meta-analysis |
| title_sort | effect of pulmonary hypertension on the prognosis of patients with severe aortic stenosis after transcatheter aortic valve replacement a systematic review and meta analysis |
| topic | Pulmonary hypertension Aortic stenosis Transcatheter aortic valve replacement TAVI Systematic review and meta-analysis |
| url | https://doi.org/10.1186/s12872-025-04962-8 |
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