Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography
The purpose of this study was to assess the usefulness of 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) in evaluating the antiatherogenic effects of irbesartan, an angiotensin II type 1 receptor blocker. Watanabe heritable hyperlipidemic rabbits were divided into the irbesarta...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2015-05-01
|
| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2015.00004 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841564098446229504 |
|---|---|
| author | Yan Zhao Keita Fukao Songji Zhao Ayahisa Watanabe Tadateru Hamada Kazuaki Yamasaki Yoichi Shimizu Naoki Kubo Naoyuki Ukon Toru Nakano Nagara Tamaki Yuji Kuge |
| author_facet | Yan Zhao Keita Fukao Songji Zhao Ayahisa Watanabe Tadateru Hamada Kazuaki Yamasaki Yoichi Shimizu Naoki Kubo Naoyuki Ukon Toru Nakano Nagara Tamaki Yuji Kuge |
| author_sort | Yan Zhao |
| collection | DOAJ |
| description | The purpose of this study was to assess the usefulness of 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) in evaluating the antiatherogenic effects of irbesartan, an angiotensin II type 1 receptor blocker. Watanabe heritable hyperlipidemic rabbits were divided into the irbesartan-treated group (75 mg/kg/d; n = 14) and the control group ( n = 14). After a 9-month treatment, rabbits underwent 18 F-FDG PET. Using the aortic lesions, autoradiography and histologic examinations were performed. PET imaging clearly visualized the thoracic lesions of control rabbits and showed a significant decrease in the 18 F-FDG uptake level of irbesartan-treated rabbits (78.8% of controls; p < .05). Irbesartan treatment significantly reduced the plaque size (43.1% of controls) and intraplaque macrophage infiltration level (48.1% of controls). The 18 F-FDG uptake level in plaques positively correlated with the plaque size ( r = .65, p < .05) and macrophage infiltration level ( r = .57, p < .05). Noninvasive imaging by 18 F-FDG PET is useful for evaluating the therapeutic effects of irbesartan and reflects inflammation, a key factor involved in the therapeutic effects. |
| format | Article |
| id | doaj-art-601307604f334ce498124652d3a990dc |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2015-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-601307604f334ce498124652d3a990dc2025-01-02T23:11:59ZengSAGE PublishingMolecular Imaging1536-01212015-05-011410.2310/7290.2015.0000410.2310_7290.2015.00004Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission TomographyYan ZhaoKeita FukaoSongji ZhaoAyahisa WatanabeTadateru HamadaKazuaki YamasakiYoichi ShimizuNaoki KuboNaoyuki UkonToru NakanoNagara TamakiYuji KugeThe purpose of this study was to assess the usefulness of 18 F-fluorodeoxyglucose positron emission tomography ( 18 F-FDG PET) in evaluating the antiatherogenic effects of irbesartan, an angiotensin II type 1 receptor blocker. Watanabe heritable hyperlipidemic rabbits were divided into the irbesartan-treated group (75 mg/kg/d; n = 14) and the control group ( n = 14). After a 9-month treatment, rabbits underwent 18 F-FDG PET. Using the aortic lesions, autoradiography and histologic examinations were performed. PET imaging clearly visualized the thoracic lesions of control rabbits and showed a significant decrease in the 18 F-FDG uptake level of irbesartan-treated rabbits (78.8% of controls; p < .05). Irbesartan treatment significantly reduced the plaque size (43.1% of controls) and intraplaque macrophage infiltration level (48.1% of controls). The 18 F-FDG uptake level in plaques positively correlated with the plaque size ( r = .65, p < .05) and macrophage infiltration level ( r = .57, p < .05). Noninvasive imaging by 18 F-FDG PET is useful for evaluating the therapeutic effects of irbesartan and reflects inflammation, a key factor involved in the therapeutic effects.https://doi.org/10.2310/7290.2015.00004 |
| spellingShingle | Yan Zhao Keita Fukao Songji Zhao Ayahisa Watanabe Tadateru Hamada Kazuaki Yamasaki Yoichi Shimizu Naoki Kubo Naoyuki Ukon Toru Nakano Nagara Tamaki Yuji Kuge Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography Molecular Imaging |
| title | Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography |
| title_full | Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography |
| title_fullStr | Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography |
| title_full_unstemmed | Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography |
| title_short | Irbesartan Attenuates Atherosclerosis in Watanabe Heritable Hyperlipidemic Rabbits: Noninvasive Imaging of Inflammation by F-Fluorodeoxyglucose Positron Emission Tomography |
| title_sort | irbesartan attenuates atherosclerosis in watanabe heritable hyperlipidemic rabbits noninvasive imaging of inflammation by f fluorodeoxyglucose positron emission tomography |
| url | https://doi.org/10.2310/7290.2015.00004 |
| work_keys_str_mv | AT yanzhao irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT keitafukao irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT songjizhao irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT ayahisawatanabe irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT tadateruhamada irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT kazuakiyamasaki irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT yoichishimizu irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT naokikubo irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT naoyukiukon irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT torunakano irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT nagaratamaki irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography AT yujikuge irbesartanattenuatesatherosclerosisinwatanabeheritablehyperlipidemicrabbitsnoninvasiveimagingofinflammationbyffluorodeoxyglucosepositronemissiontomography |