Sympathetic nervous system inhibition enhances cardiac metabolism and improves hemodynamics and glucose-insulin dynamics in obese and lean rat models

Sympathetic nervous system inhibition enhances cardiac metabolism and improves hemodynamics and glucose-insulin dynamics in obese and lean rat models

Abstract This study aimed to investigate the effects of chronic sympathoinhibition on glucose uptake by the myocardium and by the skeletal muscle in an animal model of obesity associated with leptin signaling deficiency. 6 obese Zucker rats (OZR) and 6 control Lean Zucker rats (LZR) were studied dur...

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Main Authors: Ionuț Tudorancea, Ionela Lăcrămioara Șerban, Dragomir N. Șerban, Irina-Iuliana Costache-Enache, Caratașu Cătălin, Alexandru Grațian Naum, Radu Iliescu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Cardiac metabolism
Leptin signaling
Clonidine
Obesity
Online Access:https://doi.org/10.1038/s41598-024-84218-1
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