Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)Research in context

Summary: Background: Insulin resistance (IR) is an important risk factor for multiple chronic diseases, increasing mortality and reducing life expectancy. The associations between emerging surrogates for IR, triglyceride-glucose index (TyG) and TyG-related indicators, with all-cause mortality and l...

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Main Authors:	Yang Chen, Ziyi Zhong, Ying Gue, Maciej Banach, Garry McDowell, Dimitri P. Mikhailidis, Peter P. Toth, Peter E. Penson, Tomasz Tomasik, Adam Windak, Marek Gierlotka, Tadeusz Osadnik, Agnieszka Kuras, Marcin Miga, Jacek Jozwiak, Gregory Y.H. Lip, B. Al-Shaer, W. Andrusewicz, M. Andrzejczuk-Rosa, E. Anusz-Gaszewska, A. Bagińska, P. Balawajder, G. Bańka, E. Barańska-Skubisz, B. Barbara Przyczyna, S. Bartkowiak, J. Bartodziej, M. Bartosiewicz, M. Basałyga, A. Batyra, A. Bąk, M. Bednarz, K. Bejnar, W. Bernacki, M. Betiuk-Kwiatkowska, S. Biegaj, M. Bień, W. Bilski, M. Biłogan, G. Biruta-Pawłowska, A. Biskup, B. Błaszczyk, H. Błaszczyk, T. BłońskaJankowska, B. Bogacka-Gancarczyk, M. Bojanowska, E. Bonda, J. Borowik-Skwarek, J. Borowska, J. Bruckner, J. Brzostek, M. Brzuchacz, M. Budzyńska, I. Bulzacka-Fugiel, J. Bulzak, K. Bunikowski, A. Cebulska, T. Celka, E. Cempel-Nowak, W. Chechliński, A. Chludzińska, D. Chmiel, M. Chmielewska, M. Cichy, A. Ciemięga, A. Ciepluch, I. Cieszyńska, B. Czajka, B. Czapla, M. Czerner, B. Czerwińska, W. Czuryszkiewicz, E. Daleka, Z. Dawid, M. Dąbrowska, R. Dąbrowska, D. Dąbrowski, M. Dąbrowski, K. Demczyszyn, A. Dębowska-Serwińska, J. Dmochowski, J. Dobrzecka-Kiwior, E. Dolanowska, H. Dolanowski, P. Dołek, M. Domagała, H. Domański, A. Doszel, D. Duda, M. Dudkowska, B. Dudziuk, P. Dybciak, M. Dymanowski, L. Dziadzio-Bolek, M. Eicke, H. El-Hassan, A. Eremus, M. Fąferek-Muller, E. Figura-Roguska, I. Fijałkowska-Kaczmarek, M. Flis, T. Florczak, M. Florczuk, E. Foryszewska-Witan, W. Frydrych, A. Fugiel, E. Futyma, A. Gaca-Jaroszewicz, I. Gajdamowicz, K. Ganczarski, A. Gatnar, M. Gers, A. Głowacki, K. Głód, J. Godula, J. Gołąb, M. Gołębiewski, E. Goszczyńska, K. Gościcka, A. GórnaHajduga, E. Górny, T. Grabowska, R. Grabowski, A. Graczyk-Duda, A. Gromow, A. Grudewicz, J. Gruszecka, A. Gruszka, J. Gryboś, J. Grzebyk, A. Grzechowiak, D. Grzesiak, T. Grześkowiak, A. Guźla, G. Hachuła, B. Hawel, H. Hiltawska, E. Honkowicz, J. Ignatowicz, K. Imielski, A. Iwaniura, A. JagiełaSzymala, M. Jalć-Sowała, A. Janczylik, E. Janisz, M. Janiszek, K. Jankiewicz-Ziobro, K. Januszewska, A. Jaremek, A. Jaros-Urbaniak, J. Jarosz, P. Jarosz, W. Jasiński, M. Jezierska-Wasilewska, T. Jędraszewski, A. Jędrzejowska, R. Józefowicz, K. Juźwin, E. Kacprzak, J. Kaczmarek-Szewczyk, M. Kaczmarzyk, R. Kandziora, C. Kaniewski, L. Karolak-Brandt, S. Kasperczyk, E. Kasperek-Dyląg, I. Kedziora, A. Kępa, J. Kiciński, J. Kielak-Al-Hosam, Ł. Kiełczawa, P. Kilimowicz, K. Kitliński, T. Kiwka, U. Klein, L. Klichowicz, A. Klimowicz, B. Klonowski, B. Kmolek, E. Kobyłko-Klepacka, A. Kocoń, A. Kolenda, E. Kollek, M. Kopeć, B. Koper-Kozikowska, J. Koralewska, M. Korczyńska, M.T. Korzeniewski, A. Kosk, K. Kotarski, E. Kowalczyk, M. Kowalczyk, I. Kowalik, B. Kozak-Błażkiewicz, M. Kozik, D. Kozłowska, E. Kozłowska, M. Kozłowska, T. Kozubski, K. Kózka, L. Kraśnik, T. Krężel, B. Krochmal, B. Król, G. Król, J. Król, T. Królikowska, H. Kruszewska, B. Krygier-Potrykus, W. Krystek, J. Krzysztoń, T. Kubicki, A. Kuczmierczyk-El-Hassan, W. Kuczyńska-Witek, D. Kujda, A. Kurowski, I. Kurzelewska-Solarz, M. Kwaczyńska, M. Kwaśniak, P. Kwaśniak, T. Kwietniewska, A. Łebek-Ordon, A. Lebiedowicz, L. Lejkowska-Olszewska, M. Lentas, A. Lesiewicz-Ksycińska, M. Limanowski, S. Łoniewski, J.A. Łopata, B. Łubianka, I. Łukasiuk, M. Łużna, M. Łysiak, B. Łysik, Z. Machowski, J. Maciaczyk-Kubiak, G. Mackiewicz-Zabochnicka, Z. Magner-Krężel, S. Majda, P. Malinowski, J. Mantyka, E. Marchlik, G. Martyna-Ordyniec, J. Marzec, M. Marzec, R. Matejko-Wałkiewicz, M. Mazur, M. Michalczak, A. Michalska-Żyłka, M. Michniewicz, D. Mika-Staniszewska, E. Mikiciuk, T. Mikołajczak, J. Milewski, E. Miller, B. Misiaszek, M. Mizik-Łukowska, E. Młyńczyk-Pokutycka, M. Mocek, M. Moczała, M. Morawska-Hermanowicz, P. Moryc, A. Moskal, S. Moskal, A. Moździerz, P. Moździerz, M. Mrozińska, K. Mrozowicz, G. Mróz, T. Munia, A. Mura, M. Muras-Skudlarska, E.Z. Murawska, Ł. Murawski, R. Murawski, R. Musielak, K. Nadaj, W. Nagarnowicz, R. Napierała, M. Niedźwiecka, A. Niemirski, J. Nikiel, M. Nosal, W. Nowacki, J. Nowak, M. Nyrka, A. Obst, J. Ochowicz, E. Ogonowska, M. Oleszczyk, A. Ołdakowski, I. Ołowniuk-Stefaniak, J. Ordowska-Rejman, M. Orliński, B. Osińska, A. Ostańska-Burian, A. Paciorkowska, U. Paczkowska, L. Paluch, L. Pałka, J. Paszko-Wojtkowska, A. Paszkowska, E. PawlakGanczarska, W. Pawlik, I. Pawłowska, M. Paździora, G. Permiakow, A. Petlic-Marendziak, T. Piasecka, E. Piaścińska, A. Piktel, A. Pilarska-Igielska, A. Piotrkowska, K. Piwowar-Klag, M. Planer, J. Plewa, P. Płatkiewicz, B. Płonczyńska, A. Podgórska, M. Polewska, B. Porębska, P. Porwoł, I. Potakowska, A. Prokop, J. Przybylski, M. Przybyła, H. Psiuk, K. Ptak, G. Puzoń, N. Rabiza, S. Rachwalik, E. Raczyńska, M. Raniszewska, A. Romanek-Kozik, A. Rosa, K. Rosa, A. Rozewicz, J. Rudzka-Kałwak, J. Rusak, D. Rutkowska, M. Rybacki, D. Rybińska, A. Rycyk-Sadowska, L. Rynda, B. Rynkiewicz, B. SadowskaKrawczyk, M. Sadowska-Zarzycka, B. Sarnecka, E. Sawalach-Tomanik, B. Sidor-Drozd, M. SiemieniakDębska, A. Sieroń, B. Siewniak-Zalewska, A. Sikora, B. Sitarska-Pawlina, J. Skorupski, I. SkrzypińskaMansfeld, J. Skubisz, R. Skwarek, M. Słodyczka, M. Smentek, K. Smolińska, B. Solarz, W. Sosnowska, B. Sroka, H. Stachura, D. Stangreciak, M. Staniak, Z. Stańczyk, D. Stańszczak-Ozga, E. Startek, M. Stefańczyk, R. Stelmach, E. Sternadel-Rączka, M. Sternik, J. Stępień, J. Stocka, M. Stokowska-Wojda, M. Studler-Karpińska, W. Suchorukow, W. Sufryd, B. Supłacz, J. Sygacz, Ł. Szczepański, J. Szkandera, J. Szłapa-Zellner, D. Szydlarska, T. Śliwa, J. Śliwka, Ł. Śmiejkowski, A. Targońska, E. Tesarska, M. Tobiasz, J. Tomaka, K. Tomalska-Bywalec, E. Tomiak, S. Topczewski, A. Trawińska, L. Trela-Mucha, D. Trojanowski, M. Trzaskowska, B. Trzcińska-Larska, A. Trznadel-Mozul, K. Ulanicka-Liwoch, M. Urbanowicz, A. Uthke-Kluzek, J. Waczyński, J. Walczak, L. Warsz, M. Wasyńczuk, U. Wąchała-Jędras, D. Wąsowicz, J. Wczysła, F. Wenda, E. Werner-Kubicka, E. Weryszko, B. Węgrzynowska, M. Wiaksa, M. Wiankowski, A. Wicherek, R. Wieczorek, R. Wiencek, G. Wienzek-Tatara, B. Wierzbicka, M. Wierzbicki, B. Wilczyńska, D. Wilmańska, P. Winiarski, A. Wiszniewska-Pabiszczak, M.B. Witkowska, J. Witzling, A. Wlaź, I. Wojtkowiak, J. Woydyłło, K. Woźniak, A. Wójtowicz, J. Wrona, M. Wrońska, H. Wujkowska, J. Wyrąbek, O. Wysokiński, R. Zakrzewski, J. Zaleska-Zatkalik, J. Zaleski, M. Zalewska-Dybciak, E. Zalewska, B. Zalewska-Uchimiak, J. Zawadzka-Krajewska, J. Zawadzki, A. Zieliński, E. Zubrycka, I. Żybort, M. Żymełka
Format:	Article
Language:	English
Published:	Elsevier 2025-02-01
Series:	The Lancet Regional Health. Europe
Subjects:	Triglyceride-glucose index TyG-adjusted body mass index TyG-adjusted waist circumference Insulin resistance All-cause mortality Premature mortality
Online Access:	http://www.sciencedirect.com/science/article/pii/S266677622400351X
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_version_	1846125095620182016
author	Yang Chen Ziyi Zhong Ying Gue Maciej Banach Garry McDowell Dimitri P. Mikhailidis Peter P. Toth Peter E. Penson Tomasz Tomasik Adam Windak Marek Gierlotka Tadeusz Osadnik Agnieszka Kuras Marcin Miga Jacek Jozwiak Gregory Y.H. Lip B. Al-Shaer W. Andrusewicz M. Andrzejczuk-Rosa E. Anusz-Gaszewska A. Bagińska P. Balawajder G. Bańka E. Barańska-Skubisz B. Barbara Przyczyna S. Bartkowiak J. Bartodziej M. Bartosiewicz M. Basałyga A. Batyra A. Bąk M. Bednarz K. Bejnar W. Bernacki M. Betiuk-Kwiatkowska S. Biegaj M. Bień W. Bilski M. Biłogan G. Biruta-Pawłowska A. Biskup B. Błaszczyk H. Błaszczyk T. BłońskaJankowska B. Bogacka-Gancarczyk M. Bojanowska E. Bonda J. Borowik-Skwarek J. Borowska J. Bruckner J. Brzostek M. Brzuchacz M. Budzyńska I. Bulzacka-Fugiel J. Bulzak K. Bunikowski A. Cebulska T. Celka E. Cempel-Nowak W. Chechliński A. Chludzińska D. Chmiel M. Chmielewska M. Cichy A. Ciemięga A. Ciepluch I. Cieszyńska B. Czajka B. Czapla M. Czerner B. Czerwińska W. Czuryszkiewicz E. Daleka Z. Dawid M. Dąbrowska R. Dąbrowska D. Dąbrowski M. Dąbrowski K. Demczyszyn A. Dębowska-Serwińska J. Dmochowski J. Dobrzecka-Kiwior E. Dolanowska H. Dolanowski P. Dołek M. Domagała H. Domański A. Doszel D. Duda M. Dudkowska B. Dudziuk P. Dybciak M. Dymanowski L. Dziadzio-Bolek M. Eicke H. El-Hassan A. Eremus M. Fąferek-Muller E. Figura-Roguska I. Fijałkowska-Kaczmarek M. Flis T. Florczak M. Florczuk E. Foryszewska-Witan W. Frydrych A. Fugiel E. Futyma A. Gaca-Jaroszewicz I. Gajdamowicz K. Ganczarski A. Gatnar M. Gers A. Głowacki K. Głód J. Godula J. Gołąb M. Gołębiewski E. Goszczyńska K. Gościcka A. GórnaHajduga E. Górny T. Grabowska R. Grabowski A. Graczyk-Duda A. Gromow A. Grudewicz J. Gruszecka A. Gruszka J. Gryboś J. Grzebyk A. Grzechowiak D. Grzesiak T. Grześkowiak A. Guźla G. Hachuła B. Hawel H. Hiltawska E. Honkowicz J. Ignatowicz K. Imielski A. Iwaniura A. JagiełaSzymala M. Jalć-Sowała A. Janczylik E. Janisz M. Janiszek K. Jankiewicz-Ziobro K. Januszewska A. Jaremek A. Jaros-Urbaniak J. Jarosz P. Jarosz W. Jasiński M. Jezierska-Wasilewska T. Jędraszewski A. Jędrzejowska R. Józefowicz K. Juźwin E. Kacprzak J. Kaczmarek-Szewczyk M. Kaczmarzyk R. Kandziora C. Kaniewski L. Karolak-Brandt S. Kasperczyk E. Kasperek-Dyląg I. Kedziora A. Kępa J. Kiciński J. Kielak-Al-Hosam Ł. Kiełczawa P. Kilimowicz K. Kitliński T. Kiwka U. Klein L. Klichowicz A. Klimowicz B. Klonowski B. Kmolek E. Kobyłko-Klepacka A. Kocoń A. Kolenda E. Kollek M. Kopeć B. Koper-Kozikowska J. Koralewska M. Korczyńska M.T. Korzeniewski A. Kosk K. Kotarski E. Kowalczyk M. Kowalczyk I. Kowalik B. Kozak-Błażkiewicz M. Kozik D. Kozłowska E. Kozłowska M. Kozłowska T. Kozubski K. Kózka L. Kraśnik T. Krężel B. Krochmal B. Król G. Król J. Król T. Królikowska H. Kruszewska B. Krygier-Potrykus W. Krystek J. Krzysztoń T. Kubicki A. Kuczmierczyk-El-Hassan W. Kuczyńska-Witek D. Kujda A. Kurowski I. Kurzelewska-Solarz M. Kwaczyńska M. Kwaśniak P. Kwaśniak T. Kwietniewska A. Łebek-Ordon A. Lebiedowicz L. Lejkowska-Olszewska M. Lentas A. Lesiewicz-Ksycińska M. Limanowski S. Łoniewski J.A. Łopata B. Łubianka I. Łukasiuk M. Łużna M. Łysiak B. Łysik Z. Machowski J. Maciaczyk-Kubiak G. Mackiewicz-Zabochnicka Z. Magner-Krężel S. Majda P. Malinowski J. Mantyka E. Marchlik G. Martyna-Ordyniec J. Marzec M. Marzec R. Matejko-Wałkiewicz M. Mazur M. Michalczak A. Michalska-Żyłka M. Michniewicz D. Mika-Staniszewska E. Mikiciuk T. Mikołajczak J. Milewski E. Miller B. Misiaszek M. Mizik-Łukowska E. Młyńczyk-Pokutycka M. Mocek M. Moczała M. Morawska-Hermanowicz P. Moryc A. Moskal S. Moskal A. Moździerz P. Moździerz M. Mrozińska K. Mrozowicz G. Mróz T. Munia A. Mura M. Muras-Skudlarska E.Z. Murawska Ł. Murawski R. Murawski R. Musielak K. Nadaj W. Nagarnowicz R. Napierała M. Niedźwiecka A. Niemirski J. Nikiel M. Nosal W. Nowacki J. Nowak M. Nyrka A. Obst J. Ochowicz E. Ogonowska M. Oleszczyk A. Ołdakowski I. Ołowniuk-Stefaniak J. Ordowska-Rejman M. Orliński B. Osińska A. Ostańska-Burian A. Paciorkowska U. Paczkowska L. Paluch L. Pałka J. Paszko-Wojtkowska A. Paszkowska E. PawlakGanczarska W. Pawlik I. Pawłowska M. Paździora G. Permiakow A. Petlic-Marendziak T. Piasecka E. Piaścińska A. Piktel A. Pilarska-Igielska A. Piotrkowska K. Piwowar-Klag M. Planer J. Plewa P. Płatkiewicz B. Płonczyńska A. Podgórska M. Polewska B. Porębska P. Porwoł I. Potakowska A. Prokop J. Przybylski M. Przybyła H. Psiuk K. Ptak G. Puzoń N. Rabiza S. Rachwalik E. Raczyńska M. Raniszewska A. Romanek-Kozik A. Rosa K. Rosa A. Rozewicz J. Rudzka-Kałwak J. Rusak D. Rutkowska M. Rybacki D. Rybińska A. Rycyk-Sadowska L. Rynda B. Rynkiewicz B. SadowskaKrawczyk M. Sadowska-Zarzycka B. Sarnecka E. Sawalach-Tomanik B. Sidor-Drozd M. SiemieniakDębska A. Sieroń B. Siewniak-Zalewska A. Sikora B. Sitarska-Pawlina J. Skorupski I. SkrzypińskaMansfeld J. Skubisz R. Skwarek M. Słodyczka M. Smentek K. Smolińska B. Solarz W. Sosnowska B. Sroka H. Stachura D. Stangreciak M. Staniak Z. Stańczyk D. Stańszczak-Ozga E. Startek M. Stefańczyk R. Stelmach E. Sternadel-Rączka M. Sternik J. Stępień J. Stocka M. Stokowska-Wojda M. Studler-Karpińska W. Suchorukow W. Sufryd B. Supłacz J. Sygacz Ł. Szczepański J. Szkandera J. Szłapa-Zellner D. Szydlarska T. Śliwa J. Śliwka Ł. Śmiejkowski A. Targońska E. Tesarska M. Tobiasz J. Tomaka K. Tomalska-Bywalec E. Tomiak S. Topczewski A. Trawińska L. Trela-Mucha D. Trojanowski M. Trzaskowska B. Trzcińska-Larska A. Trznadel-Mozul K. Ulanicka-Liwoch M. Urbanowicz A. Uthke-Kluzek J. Waczyński J. Walczak L. Warsz M. Wasyńczuk U. Wąchała-Jędras D. Wąsowicz J. Wczysła F. Wenda E. Werner-Kubicka E. Weryszko B. Węgrzynowska M. Wiaksa M. Wiankowski A. Wicherek R. Wieczorek R. Wiencek G. Wienzek-Tatara B. Wierzbicka M. Wierzbicki B. Wilczyńska D. Wilmańska P. Winiarski A. Wiszniewska-Pabiszczak M.B. Witkowska J. Witzling A. Wlaź I. Wojtkowiak J. Woydyłło K. Woźniak A. Wójtowicz J. Wrona M. Wrońska H. Wujkowska J. Wyrąbek O. Wysokiński R. Zakrzewski J. Zaleska-Zatkalik J. Zaleski M. Zalewska-Dybciak E. Zalewska B. Zalewska-Uchimiak J. Zawadzka-Krajewska J. Zawadzki A. Zieliński E. Zubrycka I. Żybort M. Żymełka
author_facet	Yang Chen Ziyi Zhong Ying Gue Maciej Banach Garry McDowell Dimitri P. Mikhailidis Peter P. Toth Peter E. Penson Tomasz Tomasik Adam Windak Marek Gierlotka Tadeusz Osadnik Agnieszka Kuras Marcin Miga Jacek Jozwiak Gregory Y.H. Lip B. Al-Shaer W. Andrusewicz M. Andrzejczuk-Rosa E. Anusz-Gaszewska A. Bagińska P. Balawajder G. Bańka E. Barańska-Skubisz B. Barbara Przyczyna S. Bartkowiak J. Bartodziej M. Bartosiewicz M. Basałyga A. Batyra A. Bąk M. Bednarz K. Bejnar W. Bernacki M. Betiuk-Kwiatkowska S. Biegaj M. Bień W. Bilski M. Biłogan G. Biruta-Pawłowska A. Biskup B. Błaszczyk H. Błaszczyk T. BłońskaJankowska B. Bogacka-Gancarczyk M. Bojanowska E. Bonda J. Borowik-Skwarek J. Borowska J. Bruckner J. Brzostek M. Brzuchacz M. Budzyńska I. Bulzacka-Fugiel J. Bulzak K. Bunikowski A. Cebulska T. Celka E. Cempel-Nowak W. Chechliński A. Chludzińska D. Chmiel M. Chmielewska M. Cichy A. Ciemięga A. Ciepluch I. Cieszyńska B. Czajka B. Czapla M. Czerner B. Czerwińska W. Czuryszkiewicz E. Daleka Z. Dawid M. Dąbrowska R. Dąbrowska D. Dąbrowski M. Dąbrowski K. Demczyszyn A. Dębowska-Serwińska J. Dmochowski J. Dobrzecka-Kiwior E. Dolanowska H. Dolanowski P. Dołek M. Domagała H. Domański A. Doszel D. Duda M. Dudkowska B. Dudziuk P. Dybciak M. Dymanowski L. Dziadzio-Bolek M. Eicke H. El-Hassan A. Eremus M. Fąferek-Muller E. Figura-Roguska I. Fijałkowska-Kaczmarek M. Flis T. Florczak M. Florczuk E. Foryszewska-Witan W. Frydrych A. Fugiel E. Futyma A. Gaca-Jaroszewicz I. Gajdamowicz K. Ganczarski A. Gatnar M. Gers A. Głowacki K. Głód J. Godula J. Gołąb M. Gołębiewski E. Goszczyńska K. Gościcka A. GórnaHajduga E. Górny T. Grabowska R. Grabowski A. Graczyk-Duda A. Gromow A. Grudewicz J. Gruszecka A. Gruszka J. Gryboś J. Grzebyk A. Grzechowiak D. Grzesiak T. Grześkowiak A. Guźla G. Hachuła B. Hawel H. Hiltawska E. Honkowicz J. Ignatowicz K. Imielski A. Iwaniura A. JagiełaSzymala M. Jalć-Sowała A. Janczylik E. Janisz M. Janiszek K. Jankiewicz-Ziobro K. Januszewska A. Jaremek A. Jaros-Urbaniak J. Jarosz P. Jarosz W. Jasiński M. Jezierska-Wasilewska T. Jędraszewski A. Jędrzejowska R. Józefowicz K. Juźwin E. Kacprzak J. Kaczmarek-Szewczyk M. Kaczmarzyk R. Kandziora C. Kaniewski L. Karolak-Brandt S. Kasperczyk E. Kasperek-Dyląg I. Kedziora A. Kępa J. Kiciński J. Kielak-Al-Hosam Ł. Kiełczawa P. Kilimowicz K. Kitliński T. Kiwka U. Klein L. Klichowicz A. Klimowicz B. Klonowski B. Kmolek E. Kobyłko-Klepacka A. Kocoń A. Kolenda E. Kollek M. Kopeć B. Koper-Kozikowska J. Koralewska M. Korczyńska M.T. Korzeniewski A. Kosk K. Kotarski E. Kowalczyk M. Kowalczyk I. Kowalik B. Kozak-Błażkiewicz M. Kozik D. Kozłowska E. Kozłowska M. Kozłowska T. Kozubski K. Kózka L. Kraśnik T. Krężel B. Krochmal B. Król G. Król J. Król T. Królikowska H. Kruszewska B. Krygier-Potrykus W. Krystek J. Krzysztoń T. Kubicki A. Kuczmierczyk-El-Hassan W. Kuczyńska-Witek D. Kujda A. Kurowski I. Kurzelewska-Solarz M. Kwaczyńska M. Kwaśniak P. Kwaśniak T. Kwietniewska A. Łebek-Ordon A. Lebiedowicz L. Lejkowska-Olszewska M. Lentas A. Lesiewicz-Ksycińska M. Limanowski S. Łoniewski J.A. Łopata B. Łubianka I. Łukasiuk M. Łużna M. Łysiak B. Łysik Z. Machowski J. Maciaczyk-Kubiak G. Mackiewicz-Zabochnicka Z. Magner-Krężel S. Majda P. Malinowski J. Mantyka E. Marchlik G. Martyna-Ordyniec J. Marzec M. Marzec R. Matejko-Wałkiewicz M. Mazur M. Michalczak A. Michalska-Żyłka M. Michniewicz D. Mika-Staniszewska E. Mikiciuk T. Mikołajczak J. Milewski E. Miller B. Misiaszek M. Mizik-Łukowska E. Młyńczyk-Pokutycka M. Mocek M. Moczała M. Morawska-Hermanowicz P. Moryc A. Moskal S. Moskal A. Moździerz P. Moździerz M. Mrozińska K. Mrozowicz G. Mróz T. Munia A. Mura M. Muras-Skudlarska E.Z. Murawska Ł. Murawski R. Murawski R. Musielak K. Nadaj W. Nagarnowicz R. Napierała M. Niedźwiecka A. Niemirski J. Nikiel M. Nosal W. Nowacki J. Nowak M. Nyrka A. Obst J. Ochowicz E. Ogonowska M. Oleszczyk A. Ołdakowski I. Ołowniuk-Stefaniak J. Ordowska-Rejman M. Orliński B. Osińska A. Ostańska-Burian A. Paciorkowska U. Paczkowska L. Paluch L. Pałka J. Paszko-Wojtkowska A. Paszkowska E. PawlakGanczarska W. Pawlik I. Pawłowska M. Paździora G. Permiakow A. Petlic-Marendziak T. Piasecka E. Piaścińska A. Piktel A. Pilarska-Igielska A. Piotrkowska K. Piwowar-Klag M. Planer J. Plewa P. Płatkiewicz B. Płonczyńska A. Podgórska M. Polewska B. Porębska P. Porwoł I. Potakowska A. Prokop J. Przybylski M. Przybyła H. Psiuk K. Ptak G. Puzoń N. Rabiza S. Rachwalik E. Raczyńska M. Raniszewska A. Romanek-Kozik A. Rosa K. Rosa A. Rozewicz J. Rudzka-Kałwak J. Rusak D. Rutkowska M. Rybacki D. Rybińska A. Rycyk-Sadowska L. Rynda B. Rynkiewicz B. SadowskaKrawczyk M. Sadowska-Zarzycka B. Sarnecka E. Sawalach-Tomanik B. Sidor-Drozd M. SiemieniakDębska A. Sieroń B. Siewniak-Zalewska A. Sikora B. Sitarska-Pawlina J. Skorupski I. SkrzypińskaMansfeld J. Skubisz R. Skwarek M. Słodyczka M. Smentek K. Smolińska B. Solarz W. Sosnowska B. Sroka H. Stachura D. Stangreciak M. Staniak Z. Stańczyk D. Stańszczak-Ozga E. Startek M. Stefańczyk R. Stelmach E. Sternadel-Rączka M. Sternik J. Stępień J. Stocka M. Stokowska-Wojda M. Studler-Karpińska W. Suchorukow W. Sufryd B. Supłacz J. Sygacz Ł. Szczepański J. Szkandera J. Szłapa-Zellner D. Szydlarska T. Śliwa J. Śliwka Ł. Śmiejkowski A. Targońska E. Tesarska M. Tobiasz J. Tomaka K. Tomalska-Bywalec E. Tomiak S. Topczewski A. Trawińska L. Trela-Mucha D. Trojanowski M. Trzaskowska B. Trzcińska-Larska A. Trznadel-Mozul K. Ulanicka-Liwoch M. Urbanowicz A. Uthke-Kluzek J. Waczyński J. Walczak L. Warsz M. Wasyńczuk U. Wąchała-Jędras D. Wąsowicz J. Wczysła F. Wenda E. Werner-Kubicka E. Weryszko B. Węgrzynowska M. Wiaksa M. Wiankowski A. Wicherek R. Wieczorek R. Wiencek G. Wienzek-Tatara B. Wierzbicka M. Wierzbicki B. Wilczyńska D. Wilmańska P. Winiarski A. Wiszniewska-Pabiszczak M.B. Witkowska J. Witzling A. Wlaź I. Wojtkowiak J. Woydyłło K. Woźniak A. Wójtowicz J. Wrona M. Wrońska H. Wujkowska J. Wyrąbek O. Wysokiński R. Zakrzewski J. Zaleska-Zatkalik J. Zaleski M. Zalewska-Dybciak E. Zalewska B. Zalewska-Uchimiak J. Zawadzka-Krajewska J. Zawadzki A. Zieliński E. Zubrycka I. Żybort M. Żymełka
author_sort	Yang Chen
collection	DOAJ
description	Summary: Background: Insulin resistance (IR) is an important risk factor for multiple chronic diseases, increasing mortality and reducing life expectancy. The associations between emerging surrogates for IR, triglyceride-glucose index (TyG) and TyG-related indicators, with all-cause mortality and life expectancy in middle-aged and older patients in primary care are unclear. Methods: This study originated from the Polish primary care cohort LIPIDOGRAM2015, including patients aged ≥45 years. Baseline fasting triglycerides and fasting glucose were used to derive TyG. Other TyG-related indicators included TyG-adjusted body mass index (TyG-BMI), TyG-adjusted waist circumference (TyG-WC), TyG-adjusted waist-to-hip, and TyG-adjusted waist-to-height. In this longitudinal analysis, we assessed associations between TyG-related indicators with total all-cause mortality, premature (age at death ≤75 years) all-cause mortality and years of life lost (YLL). Findings: We included 10,688 patients (mean age 61.8 ± 9.3 years; 63.5% female). Cumulative total and premature all-cause mortality were 7.2% and 4.6%, respectively, during 5.7 years (IQR 5.6–5.7) of follow-up. Lowest (Q1) and highest quartile (Q4) of TyG-BMI and TyG-WC were associated with total all-cause mortality (second quartile [Q2]: reference; TyG-BMI: Q1: aHR 1.33, 95% CI 1.07–1.65, Q4: aHR 1.28, 95% CI 1.03–1.58; TyG-WC: Q1: aHR 1.44, 95% CI 1.14–1.82, Q4: aHR 1.29, 95% CI 1.04–1.59), similar results for premature all-cause mortality. Within age 45–80 years, compared with Q2 and third quartile, YLL were 4.49 and 5.46 years for TyG-BMI Q1 and Q4, respectively, 3.24 and 5.31 years for TyG-WC Q1 and Q4, respectively. Interpretation: TyG-BMI and TyG-WC demonstrated a U-shaped association with total and premature all-cause mortality. Low and high levels of TyG-BMI and TyG-WC were associated with reduced life expectancy. Despite the relatively short follow-up period, significant associations were still observed, but longer follow-up studies are required to further explore these relationships. Funding: Polish Lipid Association, College of Family Physician in Poland, Valeant in Poland.
format	Article
id	doaj-art-5fd46e0172cf4eefbbf61cffaec5f646
institution	Kabale University
issn	2666-7762
language	English
publishDate	2025-02-01
publisher	Elsevier
record_format	Article
series	The Lancet Regional Health. Europe
spelling	doaj-art-5fd46e0172cf4eefbbf61cffaec5f6462024-12-13T11:05:29ZengElsevierThe Lancet Regional Health. Europe2666-77622025-02-0149101182Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)Research in contextYang Chen0Ziyi Zhong1Ying Gue2Maciej Banach3Garry McDowell4Dimitri P. Mikhailidis5Peter P. Toth6Peter E. Penson7Tomasz Tomasik8Adam Windak9Marek Gierlotka10Tadeusz Osadnik11Agnieszka Kuras12Marcin Miga13Jacek Jozwiak14Gregory Y.H. Lip15B. Al-ShaerW. AndrusewiczM. Andrzejczuk-RosaE. Anusz-GaszewskaA. BagińskaP. BalawajderG. BańkaE. Barańska-SkubiszB. Barbara PrzyczynaS. BartkowiakJ. BartodziejM. BartosiewiczM. BasałygaA. BatyraA. BąkM. BednarzK. BejnarW. BernackiM. Betiuk-KwiatkowskaS. BiegajM. BieńW. BilskiM. BiłoganG. Biruta-PawłowskaA. BiskupB. BłaszczykH. BłaszczykT. BłońskaJankowskaB. Bogacka-GancarczykM. BojanowskaE. BondaJ. Borowik-SkwarekJ. BorowskaJ. BrucknerJ. BrzostekM. BrzuchaczM. BudzyńskaI. Bulzacka-FugielJ. BulzakK. BunikowskiA. CebulskaT. CelkaE. Cempel-NowakW. ChechlińskiA. ChludzińskaD. ChmielM. ChmielewskaM. CichyA. CiemięgaA. CiepluchI. CieszyńskaB. CzajkaB. CzaplaM. CzernerB. CzerwińskaW. CzuryszkiewiczE. DalekaZ. DawidM. DąbrowskaR. DąbrowskaD. DąbrowskiM. DąbrowskiK. DemczyszynA. Dębowska-SerwińskaJ. DmochowskiJ. Dobrzecka-KiwiorE. DolanowskaH. DolanowskiP. DołekM. DomagałaH. DomańskiA. DoszelD. DudaM. DudkowskaB. DudziukP. DybciakM. DymanowskiL. Dziadzio-BolekM. EickeH. El-HassanA. EremusM. Fąferek-MullerE. Figura-RoguskaI. Fijałkowska-KaczmarekM. FlisT. FlorczakM. FlorczukE. Foryszewska-WitanW. FrydrychA. FugielE. FutymaA. Gaca-JaroszewiczI. GajdamowiczK. GanczarskiA. GatnarM. GersA. GłowackiK. GłódJ. GodulaJ. GołąbM. GołębiewskiE. GoszczyńskaK. GościckaA. GórnaHajdugaE. GórnyT. GrabowskaR. GrabowskiA. Graczyk-DudaA. GromowA. GrudewiczJ. GruszeckaA. GruszkaJ. GrybośJ. GrzebykA. GrzechowiakD. GrzesiakT. GrześkowiakA. GuźlaG. HachułaB. HawelH. HiltawskaE. HonkowiczJ. IgnatowiczK. ImielskiA. IwaniuraA. JagiełaSzymalaM. Jalć-SowałaA. JanczylikE. JaniszM. JaniszekK. Jankiewicz-ZiobroK. JanuszewskaA. JaremekA. Jaros-UrbaniakJ. JaroszP. JaroszW. JasińskiM. Jezierska-WasilewskaT. JędraszewskiA. JędrzejowskaR. JózefowiczK. JuźwinE. KacprzakJ. Kaczmarek-SzewczykM. KaczmarzykR. KandzioraC. KaniewskiL. Karolak-BrandtS. KasperczykE. Kasperek-DylągI. KedzioraA. KępaJ. KicińskiJ. Kielak-Al-HosamŁ. KiełczawaP. KilimowiczK. KitlińskiT. KiwkaU. KleinL. KlichowiczA. KlimowiczB. KlonowskiB. KmolekE. Kobyłko-KlepackaA. KocońA. KolendaE. KollekM. KopećB. Koper-KozikowskaJ. KoralewskaM. KorczyńskaM.T. KorzeniewskiA. KoskK. KotarskiE. KowalczykM. KowalczykI. KowalikB. Kozak-BłażkiewiczM. KozikD. KozłowskaE. KozłowskaM. KozłowskaT. KozubskiK. KózkaL. KraśnikT. KrężelB. KrochmalB. KrólG. KrólJ. KrólT. KrólikowskaH. KruszewskaB. Krygier-PotrykusW. KrystekJ. KrzysztońT. KubickiA. Kuczmierczyk-El-HassanW. Kuczyńska-WitekD. KujdaA. KurowskiI. Kurzelewska-SolarzM. KwaczyńskaM. KwaśniakP. KwaśniakT. KwietniewskaA. Łebek-OrdonA. LebiedowiczL. Lejkowska-OlszewskaM. LentasA. Lesiewicz-KsycińskaM. LimanowskiS. ŁoniewskiJ.A. ŁopataB. ŁubiankaI. ŁukasiukM. ŁużnaM. ŁysiakB. ŁysikZ. MachowskiJ. Maciaczyk-KubiakG. Mackiewicz-ZabochnickaZ. Magner-KrężelS. MajdaP. MalinowskiJ. MantykaE. MarchlikG. Martyna-OrdyniecJ. MarzecM. MarzecR. Matejko-WałkiewiczM. MazurM. MichalczakA. Michalska-ŻyłkaM. MichniewiczD. Mika-StaniszewskaE. MikiciukT. MikołajczakJ. MilewskiE. MillerB. MisiaszekM. Mizik-ŁukowskaE. Młyńczyk-PokutyckaM. MocekM. MoczałaM. Morawska-HermanowiczP. MorycA. MoskalS. MoskalA. MoździerzP. MoździerzM. MrozińskaK. MrozowiczG. MrózT. MuniaA. MuraM. Muras-SkudlarskaE.Z. MurawskaŁ. MurawskiR. MurawskiR. MusielakK. NadajW. NagarnowiczR. NapierałaM. NiedźwieckaA. NiemirskiJ. NikielM. NosalW. NowackiJ. NowakM. NyrkaA. ObstJ. OchowiczE. OgonowskaM. OleszczykA. OłdakowskiI. Ołowniuk-StefaniakJ. Ordowska-RejmanM. OrlińskiB. OsińskaA. Ostańska-BurianA. PaciorkowskaU. PaczkowskaL. PaluchL. PałkaJ. Paszko-WojtkowskaA. PaszkowskaE. PawlakGanczarskaW. PawlikI. PawłowskaM. PaździoraG. PermiakowA. Petlic-MarendziakT. PiaseckaE. PiaścińskaA. PiktelA. Pilarska-IgielskaA. PiotrkowskaK. Piwowar-KlagM. PlanerJ. PlewaP. PłatkiewiczB. PłonczyńskaA. PodgórskaM. PolewskaB. PorębskaP. PorwołI. PotakowskaA. ProkopJ. PrzybylskiM. PrzybyłaH. PsiukK. PtakG. PuzońN. RabizaS. RachwalikE. RaczyńskaM. RaniszewskaA. Romanek-KozikA. RosaK. RosaA. RozewiczJ. Rudzka-KałwakJ. RusakD. RutkowskaM. RybackiD. RybińskaA. Rycyk-SadowskaL. RyndaB. RynkiewiczB. SadowskaKrawczykM. Sadowska-ZarzyckaB. SarneckaE. Sawalach-TomanikB. Sidor-DrozdM. SiemieniakDębskaA. SierońB. Siewniak-ZalewskaA. SikoraB. Sitarska-PawlinaJ. SkorupskiI. SkrzypińskaMansfeldJ. SkubiszR. SkwarekM. SłodyczkaM. SmentekK. SmolińskaB. SolarzW. SosnowskaB. SrokaH. StachuraD. StangreciakM. StaniakZ. StańczykD. Stańszczak-OzgaE. StartekM. StefańczykR. StelmachE. Sternadel-RączkaM. SternikJ. StępieńJ. StockaM. Stokowska-WojdaM. Studler-KarpińskaW. SuchorukowW. SufrydB. SupłaczJ. SygaczŁ. SzczepańskiJ. SzkanderaJ. Szłapa-ZellnerD. SzydlarskaT. ŚliwaJ. ŚliwkaŁ. ŚmiejkowskiA. TargońskaE. TesarskaM. TobiaszJ. TomakaK. Tomalska-BywalecE. TomiakS. TopczewskiA. TrawińskaL. Trela-MuchaD. TrojanowskiM. TrzaskowskaB. Trzcińska-LarskaA. Trznadel-MozulK. Ulanicka-LiwochM. UrbanowiczA. Uthke-KluzekJ. WaczyńskiJ. WalczakL. WarszM. WasyńczukU. Wąchała-JędrasD. WąsowiczJ. WczysłaF. WendaE. Werner-KubickaE. WeryszkoB. WęgrzynowskaM. WiaksaM. WiankowskiA. WicherekR. WieczorekR. WiencekG. Wienzek-TataraB. WierzbickaM. WierzbickiB. WilczyńskaD. WilmańskaP. WiniarskiA. Wiszniewska-PabiszczakM.B. WitkowskaJ. WitzlingA. WlaźI. WojtkowiakJ. WoydyłłoK. WoźniakA. WójtowiczJ. WronaM. WrońskaH. WujkowskaJ. WyrąbekO. WysokińskiR. ZakrzewskiJ. Zaleska-ZatkalikJ. ZaleskiM. Zalewska-DybciakE. ZalewskaB. Zalewska-UchimiakJ. Zawadzka-KrajewskaJ. ZawadzkiA. ZielińskiE. ZubryckaI. ŻybortM. ŻymełkaLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United KingdomLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Department of Musculoskeletal Ageing and Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United KingdomLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United KingdomCiccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; Department of Preventive Cardiology and Lipidology, Medical University of Lodz (MUL), Rzgowska 281/289, Lodz 93-338, Poland; Department of Cardiology and Adult Congenital Heart Diseases, Polish Mother’s Memorial Hospital Research Institute (PMMHRI), Rzgowska 281/289, Lodz 93-338, Poland; Cardiovascular Research Centre, University of Zielona Gora, Zyty 28, Zielona Gora 65-046, PolandLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Liverpool, United KingdomDepartment of Clinical Biochemistry, Royal Free Hospital Campus, University College London Medical School, University College London (UCL), Pond St., London NW3 2QG, UKCiccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA; 14CGH Medical Center, Department of Preventive Cardiology, 101 East Miller Road, Sterling, IL 61081, USAClinical Pharmacy & Therapeutics Research Group, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, UK; Liverpool Centre for Cardiovascular Science, University of Liverpool, Brownlow Hill, Liverpool L69 7TX, UK; Department of Cardiovascular and Metabolic Medicine, Institute of Life Course and Medical Sciences, University of Liverpool, 6 West Derby St., Liverpool L7 8TX, UKDepartment of Family Medicine, Jagiellonian University Medical College, Bochenska 4 Street, Krakow 31-061, PolandDepartment of Family Medicine, Jagiellonian University Medical College, Bochenska 4 Street, Krakow 31-061, PolandDepartment of Cardiology, Institute of Medical Sciences, University of Opole, Oleska 48, Opole 45-052, PolandDepartment of Pharmacology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland, Jordana 38 Street, Zabrze 41-808, PolandMultiprofile Medical Simulation Center, University of Opole, Oleska 48 Street, Opole 45-052, PolandClinical University Hospital, Witosa 26 Avenue, Opole 45-401, PolandDepartment of Family Medicine and Public Health, Institute of Medical Sciences, University of Opole, Oleska 48, Opole 45-052, PolandLiverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart & Chest Hospital, Liverpool, United Kingdom; Danish Center for Health Services Research, Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Medical University of Bialystok, Bialystok 15-089, Poland; Corresponding author. Liverpool Centre for Cardiovascular Science at University of Liverpool, Liverpool John Moores University and Liverpool Heart and Chest Hospital, William Henry Duncan Building, 6 West Derby Street, Liverpool L7 8TX, United Kingdom.Summary: Background: Insulin resistance (IR) is an important risk factor for multiple chronic diseases, increasing mortality and reducing life expectancy. The associations between emerging surrogates for IR, triglyceride-glucose index (TyG) and TyG-related indicators, with all-cause mortality and life expectancy in middle-aged and older patients in primary care are unclear. Methods: This study originated from the Polish primary care cohort LIPIDOGRAM2015, including patients aged ≥45 years. Baseline fasting triglycerides and fasting glucose were used to derive TyG. Other TyG-related indicators included TyG-adjusted body mass index (TyG-BMI), TyG-adjusted waist circumference (TyG-WC), TyG-adjusted waist-to-hip, and TyG-adjusted waist-to-height. In this longitudinal analysis, we assessed associations between TyG-related indicators with total all-cause mortality, premature (age at death ≤75 years) all-cause mortality and years of life lost (YLL). Findings: We included 10,688 patients (mean age 61.8 ± 9.3 years; 63.5% female). Cumulative total and premature all-cause mortality were 7.2% and 4.6%, respectively, during 5.7 years (IQR 5.6–5.7) of follow-up. Lowest (Q1) and highest quartile (Q4) of TyG-BMI and TyG-WC were associated with total all-cause mortality (second quartile [Q2]: reference; TyG-BMI: Q1: aHR 1.33, 95% CI 1.07–1.65, Q4: aHR 1.28, 95% CI 1.03–1.58; TyG-WC: Q1: aHR 1.44, 95% CI 1.14–1.82, Q4: aHR 1.29, 95% CI 1.04–1.59), similar results for premature all-cause mortality. Within age 45–80 years, compared with Q2 and third quartile, YLL were 4.49 and 5.46 years for TyG-BMI Q1 and Q4, respectively, 3.24 and 5.31 years for TyG-WC Q1 and Q4, respectively. Interpretation: TyG-BMI and TyG-WC demonstrated a U-shaped association with total and premature all-cause mortality. Low and high levels of TyG-BMI and TyG-WC were associated with reduced life expectancy. Despite the relatively short follow-up period, significant associations were still observed, but longer follow-up studies are required to further explore these relationships. Funding: Polish Lipid Association, College of Family Physician in Poland, Valeant in Poland.http://www.sciencedirect.com/science/article/pii/S266677622400351XTriglyceride-glucose indexTyG-adjusted body mass indexTyG-adjusted waist circumferenceInsulin resistanceAll-cause mortalityPremature mortality
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Zaleska-Zatkalik J. Zaleski M. Zalewska-Dybciak E. Zalewska B. Zalewska-Uchimiak J. Zawadzka-Krajewska J. Zawadzki A. Zieliński E. Zubrycka I. Żybort M. Żymełka Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)Research in context The Lancet Regional Health. Europe Triglyceride-glucose index TyG-adjusted body mass index TyG-adjusted waist circumference Insulin resistance All-cause mortality Premature mortality
title	Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)Research in context
title_full	Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)Research in context
title_fullStr	Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)Research in context
title_full_unstemmed	Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)Research in context
title_short	Impact of surrogates for insulin resistance on mortality and life expectancy in primary care: a nationwide cross-sectional study with registry linkage (LIPIDOGRAM2015)Research in context
title_sort	impact of surrogates for insulin resistance on mortality and life expectancy in primary care a nationwide cross sectional study with registry linkage lipidogram2015 research in context
topic	Triglyceride-glucose index TyG-adjusted body mass index TyG-adjusted waist circumference Insulin resistance All-cause mortality Premature mortality
url	http://www.sciencedirect.com/science/article/pii/S266677622400351X
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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT hpsiuk impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT kptak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT gpuzon impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT nrabiza impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT srachwalik impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT eraczynska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mraniszewska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT aromanekkozik impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT arosa impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT krosa 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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT drybinska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT arycyksadowska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT lrynda impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT brynkiewicz impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT bsadowskakrawczyk 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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT iskrzypinskamansfeld impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jskubisz impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT rskwarek impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT msłodyczka impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT msmentek 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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT dstangreciak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mstaniak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT zstanczyk impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT dstanszczakozga impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT estartek 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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jstocka impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mstokowskawojda impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mstudlerkarpinska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT wsuchorukow impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT wsufryd 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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT dszydlarska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT tsliwa impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jsliwka impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT łsmiejkowski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT atargonska 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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT stopczewski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT atrawinska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT ltrelamucha impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT dtrojanowski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mtrzaskowska 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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jwaczynski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jwalczak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT lwarsz impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mwasynczuk impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT uwachałajedras impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT dwasowicz impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jwczysła impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT fwenda impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT ewernerkubicka impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT eweryszko 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impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT rwiencek impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT gwienzektatara impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT bwierzbicka impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mwierzbicki impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT bwilczynska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT dwilmanska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT pwiniarski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT awiszniewskapabiszczak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mbwitkowska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jwitzling impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT awlaz impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT iwojtkowiak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jwoydyłło impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT kwozniak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT awojtowicz impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jwrona impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mwronska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT hwujkowska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jwyrabek impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT owysokinski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT rzakrzewski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jzaleskazatkalik impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jzaleski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mzalewskadybciak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT ezalewska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT bzalewskauchimiak impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jzawadzkakrajewska impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT jzawadzki impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT azielinski impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT ezubrycka impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT izybort impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext AT mzymełka impactofsurrogatesforinsulinresistanceonmortalityandlifeexpectancyinprimarycareanationwidecrosssectionalstudywithregistrylinkagelipidogram2015researchincontext

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