Thyroid Mutations and Implications for Clinical Treatment
This article provides an overview of the evolving paradigm in the management of aggressive thyroid cancer. While differentiated thyroid cancer (DTC) generally has a favorable prognosis, subsets such as radioactive iodine-refractory DTC, medullary thyroid cancer, and anaplastic thyroid cancer present...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Head & Neck Physicians and Surgeons |
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| Online Access: | https://journals.lww.com/10.4103/jhnps.jhnps_122_24 |
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| _version_ | 1841545740928679936 |
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| author | Emily S. Zhang Joseph Scharpf |
| author_facet | Emily S. Zhang Joseph Scharpf |
| author_sort | Emily S. Zhang |
| collection | DOAJ |
| description | This article provides an overview of the evolving paradigm in the management of aggressive thyroid cancer. While differentiated thyroid cancer (DTC) generally has a favorable prognosis, subsets such as radioactive iodine-refractory DTC, medullary thyroid cancer, and anaplastic thyroid cancer present significant challenges with high mortality rates. The identification of aggressive diseases through molecular testing has revolutionized risk stratification and treatment options, allowing for targeted therapies that match-specific genetic alterations. DTCs can have BRAF-like or RAS-like pathways of driver mutations with strong genotype–phenotype correlations, which are targetable through multikinase and tyrosine kinase inhibitors. Case studies illustrate how molecular profiling can guide clinical decisions and enhance treatment outcomes. Ultimately, the incorporation of genetic insights into clinical practice is essential for improving management strategies, minimizing overtreatment, and optimizing patient care in advanced thyroid cancer. |
| format | Article |
| id | doaj-art-5fb6aae5933348a29a445cb659e70a37 |
| institution | Kabale University |
| issn | 2347-8128 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Head & Neck Physicians and Surgeons |
| spelling | doaj-art-5fb6aae5933348a29a445cb659e70a372025-01-11T15:18:38ZengWolters Kluwer Medknow PublicationsJournal of Head & Neck Physicians and Surgeons2347-81282024-12-01122838810.4103/jhnps.jhnps_122_24Thyroid Mutations and Implications for Clinical TreatmentEmily S. ZhangJoseph ScharpfThis article provides an overview of the evolving paradigm in the management of aggressive thyroid cancer. While differentiated thyroid cancer (DTC) generally has a favorable prognosis, subsets such as radioactive iodine-refractory DTC, medullary thyroid cancer, and anaplastic thyroid cancer present significant challenges with high mortality rates. The identification of aggressive diseases through molecular testing has revolutionized risk stratification and treatment options, allowing for targeted therapies that match-specific genetic alterations. DTCs can have BRAF-like or RAS-like pathways of driver mutations with strong genotype–phenotype correlations, which are targetable through multikinase and tyrosine kinase inhibitors. Case studies illustrate how molecular profiling can guide clinical decisions and enhance treatment outcomes. Ultimately, the incorporation of genetic insights into clinical practice is essential for improving management strategies, minimizing overtreatment, and optimizing patient care in advanced thyroid cancer.https://journals.lww.com/10.4103/jhnps.jhnps_122_24mutationssurgerythyroid cancer |
| spellingShingle | Emily S. Zhang Joseph Scharpf Thyroid Mutations and Implications for Clinical Treatment Journal of Head & Neck Physicians and Surgeons mutations surgery thyroid cancer |
| title | Thyroid Mutations and Implications for Clinical Treatment |
| title_full | Thyroid Mutations and Implications for Clinical Treatment |
| title_fullStr | Thyroid Mutations and Implications for Clinical Treatment |
| title_full_unstemmed | Thyroid Mutations and Implications for Clinical Treatment |
| title_short | Thyroid Mutations and Implications for Clinical Treatment |
| title_sort | thyroid mutations and implications for clinical treatment |
| topic | mutations surgery thyroid cancer |
| url | https://journals.lww.com/10.4103/jhnps.jhnps_122_24 |
| work_keys_str_mv | AT emilyszhang thyroidmutationsandimplicationsforclinicaltreatment AT josephscharpf thyroidmutationsandimplicationsforclinicaltreatment |